Hippuric (Females Under Age 13)

Optimal Result: 0 - 717 mmol/mol creatinine.

Hippuric acid is a conjugate (=a compound formed by the joining of two or more compounds) of glycine and benzoic acid formed in the liver.

Most hippuric acid in urine is derived from microbial breakdown of chlorogenic acid to benzoic acid.

Chlorogenic acid is a common substance in beverages and in many fruits and vegetables, including apples, pears, tea, coffee, sunflower seeds, carrots, blueberries, cherries, potatoes, tomatoes, eggplant, sweet potatoes, and peaches. Benzoic acid is present in high amounts in cranberry juice and is a food preservative.

The workplace is the most common source of toluene exposure, but toluene may be absorbed from outgassing of new carpets and other building materials, or absorbed during recreational abuse of solvents such as glue-sniffing.

How to treat bacterial overgrowth?

Bacterial overgrowth can be treated with natural anti-bacterial agents and/or probiotics (30-50 billion cfu’s) that include Lactobacillus rhamnosus.

Because most hippuric acid in urine is from GI sources, this marker is a poor indicator of toluene exposure and is being replaced by other markers in occupational safety testing.

What does it mean if your Hippuric (Females Under Age 13) result is too high?

If your hippuric acid levels are increased in an Organic Acids Test (OAT), it may indicate several potential underlying factors:

→ Bacterial Overgrowth: Elevated hippuric acid levels can be associated with gut bacterial overgrowth, particularly with certain strains of bacteria. This suggests an imbalance in the gut microbiome.

→ Diet and Food Choices: High hippuric acid levels can also result from dietary factors or food choices. Certain foods can contribute to increased hippuric acid.

→ Toxic Exposure: Exposure to certain environmental toxins, such as the solvent toluene, can lead to elevated hippuric acid levels.

→ Mycotoxins: In some cases, elevated hippuric acid levels may be an indicator of mold mycotoxins.

The underlying cause of the elevation will determine the appropriate course of action.

Potential treatments may include dietary adjustments, probiotics for gut health, and toxin exposure reduction strategies.

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High hippuric acid may derive from food, GI bacterial activity, or exposure to the solvent toluene. Hippuric acid is a conjugate of glycine and benzoic acid formed in the liver. Most hippuric acid in urine is derived from microbial breakdown of chlorogenic acid to benzoic acid. Chlorogenic acid is a common substance in beverages and in many fruits and vegetables, including apples, pears, tea, coffee, sunflower seeds, carrots, blueberries, cherries, potatoes, tomatoes, eggplant, sweet potatoes, and peaches. Benzoic acid is present in high amounts in cranberry juice and is a food preservative. The workplace is the most common source of toluene exposure, but toluene may be absorbed from outgassing of new carpets and other building materials, or absorbed during recreational abuse of solvents such as glue-sniffing. Because most hippuric acid in urine is from GI sources, this marker is a poor indicator of toluene exposure and is being replaced by other markers in occupational safety testing. Bacterial overgrowth can be treated with natural anti-bacterial agents and/or probiotics (30-50 billion cfu’s) that include Lactobacillus rhamnosus.

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