Elevation indicates riboflavin deficiency (vitamin B2), a common factor in moderate urinary increases of glutaric acid.
Other possible factors include:
- fatty acid oxidation defects
- metabolic effects of valproic acid (Depakene),
- or celiac disease.
The probability of a genetic disease is higher with very high values.
The use of dietary supplements containing riboflavin and coenzyme Q10 may improve clinical symptoms.
This compound may be elevated in about 10% of children with autism.
Elevation indicates riboflavin (vitamin B2) deficiency. Other possible factors include fatty acid oxidation defects, and metabolic effects of valproic acid (Depakene), or celiac disease. The probability of a genetic disease is higher with very high values. The use of dietary supplements containing riboflavin and coenzyme Q10 may improve clinical symptoms. This compound may be elevated in about 10% of children with autism.
Possible causes:
- Low B2
- Inborn error of metabolism
- Associated with CETP genetic polymorphism
Additional investigations:
- Red blood cell B2
- Genetic Diagnostic Testing
Treatment considerations:
- Supplement B2
- Consider mitochondrial support nutrients (e.g. CoQ10
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2-Hydroxybutyric, 2-Hydroxyhippuric, 2-Hydroxyisocaproic, 2-Hydroxyisovaleric, 2-Hydroxyphenylacetic, 2-Oxo-4-methiolbutyric, 2-Oxoglutaric, 2-Oxoisocaproic, 2-Oxoisovaleric, 3-Hydroxy-3-methylglutaric (HMG), 3-Hydroxybutyric, 3-Hydroxyglutaric, 3-Indoleacetic, 3-Methyl-2-oxovaleric, 3-Methylglutaconic, 3-Methylglutaric, 3-Oxoglutaric, 4-Cresol, 4-Hydroxybenzoic, 4-Hydroxybutyric, 4-Hydroxyhippuric, 4-Hydroxyphenylacetic, 4-Hydroxyphenyllactic, 5-Hydroxyindoleacetic (5-HIAA), 5-Hydroxymethyl-2-furoic, Acetoacetic, Aconitic, Adipic, Arabinose, Ascorbic, Carboxycitric, Citramalic, Citric, DHPPA (Beneficial Bacteria), Dihydroxyphenylacetic (DOPAC), Ethylmalonic, Fumaric, Furan-2,5-dicarboxylic, Furancarbonylglycine, Glutaric, Glyceric, Glycolic, Hippuric, Homogentisic, Homovanillic (HVA), HPHPA, HVA / VMA Ratio, HVA/ DOPAC Ratio, Kynurenic, Lactic, Malic, Malonic, Mandelic, Methylcitric, Methylmalonic, Methylsuccinic, N-Acetylaspartic, N-Acetylcysteine (NAC), Orotic, Oxalic, Pantothenic (B5), Phenyllactic, Phenylpyruvic, Phosphoric, Pyridoxic (B6), Pyroglutamic, Pyruvic, Quinolinic, Quinolinic / 5-HIAA Ratio, Sebacic, Suberic, Succinic, Tartaric, Thymine, Tricarballylic, Uracil, Vanillylmandelic (VMA)
