Other names: AKG, α-KG, 2-oxoglutarate, 2OG
2-Oxoglutaric acid is an organic acid that is important for the proper metabolism of all essential amino acids. It is formed in the Krebs cycle, the energy-producing process that occurs in most body cells.
The Krebs cycle (aka Citric Acid cycle) is a series of chemical reactions used by all aerobic organisms to release stored energy through the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins into ATP.
2-Oxoglutaric acid is the nitrogen-free portion of the amino acids known as glutamine and glutamic acid, which is involved in protein synthesis that may play a role in supporting healthy blood glucose levels. 2-Oxoglutaric acid helps maintain normal levels of ammonia in the brain, muscles and kidneys, as well as the body’s nitrogen balance in body tissues and fluids.
2-Oxoglutaric acid is used by cells during growth and in healing from injuries and other wounds, and is especially important in the healing of muscle tissue.
2-Oxoglutaric acid is one of the most important nitrogen transporters in metabolic pathways. The amino groups of amino acids are attached to it (by transamination) and carried to the liver where the urea cycle takes place.
References:
- Alpha-Ketoglutarate: Physiological Functions and Applications [L]
- Urinary alpha-ketoglutarate is elevated in patients with hyperinsulinism-hyperammonemia syndrome. [L]
Understand and improve your laboratory results with our health dashboard.
Upload your lab reports and get interpretation today.
Our technology helps to understand, combine, track, organize, and act on your medical lab test results.
Elevated levels of 2-Oxoglutaric suggest dietary vitamin deficiencies or supplementation with 2-ketoglutaric acid. Coenzyme A (derived from pantothenic acid), flavin adenine dinucleotide (FAD) (derived from riboflavin), and thiamine are required for conversion of 2-oxoglutaric acid to succinyl-CoA.
Interpret Your Lab Results
Upload your lab report and we’ll interpret and provide you with recomendations today.
Get StartedGet Started With Our Personal Plan
Advanced Plan
Unlimited Plan
Are You a Health Professional?
Get started with our professional plan
Welcome to Healthmatters Pro.
Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place. Learn more
Pro Plan
for health professionals
$45 per month
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.
2-Hydroxybutyric, 2-Hydroxybutyric (Males Age 13 and Over), 2-Hydroxyhippuric, 2-Hydroxyhippuric (Males Age 13 and Over), 2-Hydroxyisocaproic, 2-Hydroxyisocaproic (Males Age 13 and Over), 2-Hydroxyisovaleric, 2-Hydroxyisovaleric (Males Age 13 and Over), 2-Hydroxyphenylacetic, 2-Hydroxyphenylacetic (Males Age 13 and Over), 2-Oxo-4-methiolbutyric, 2-Oxo-4-methiolbutyric (Males Age 13 and Over), 2-Oxoglutaric, 2-Oxoglutaric (Males Age 13 and Over), 2-Oxoisocaproic, 2-Oxoisocaproic (Males Age 13 and Over), 2-Oxoisovaleric, 2-Oxoisovaleric (Males Age 13 and Over), 3-Hydroxy-3-methylglutaric (HMG), 3-Hydroxy-3-methylglutaric (Males Age 13 and Over), 3-Hydroxybutyric, 3-Hydroxybutyric (Males Age 13 and Over), 3-Hydroxyglutaric, 3-Hydroxyglutaric (Males Age 13 and Over), 3-Indoleacetic, 3-Indoleacetic (Males Age 13 and Over), 3-Methyl-2-oxovaleric, 3-Methyl-2-oxovaleric (Males Age 13 and Over), 3-Methylglutaconic, 3-Methylglutaconic (Males Age 13 and Over), 3-Methylglutaric, 3-Methylglutaric (Males Age 13 and Over), 3-Oxoglutaric, 3-Oxoglutaric (Males Age 13 and Over), 4-Cresol, 4-Cresol (Males Age 13 and Over), 4-Hydroxybenzoic, 4-Hydroxybenzoic (Males Age 13 and Over), 4-Hydroxybutyric, 4-Hydroxybutyric (Males Age 13 and Over), 4-Hydroxyhippuric, 4-Hydroxyhippuric (Males Age 13 and Over), 4-Hydroxyphenylacetic, 4-Hydroxyphenylacetic (Males Age 13 and Over), 4-Hydroxyphenyllactic, 4-Hydroxyphenyllactic (Males Age 13 and Over), 5-Hydroxyindoleacetic (5-HIAA), 5-Hydroxyindoleacetic (5-HIAA) (Males Age 13 and Over), 5-Hydroxymethyl-2-furoic, 5-Hydroxymethyl-2-furoic (Males Age 13 and Over), Acetoacetic, Acetoacetic (Males Age 13 and Over), Aconitic, Aconitic (Males Age 13 and Over), Adipic, Adipic (Males Age 13 and Over), Arabinose, Arabinose (Males Age 13 and Over), Ascorbic, Ascorbic (Males Age 13 and Over), Carboxycitric, Carboxycitric (Males Age 13 and Over), Citramalic, Citramalic (Males Age 13 and Over), Citric, Citric (Males Age 13 and Over), DHPPA (Beneficial Bacteria), DHPPA (Beneficial Bacteria) (Males Age 13 and Over), Dihydroxyphenylacetic (DOPAC), Dihydroxyphenylacetic (DOPAC) (Males Age 13 and Over), Ethylmalonic, Ethylmalonic (Males Age 13 and Over), Fumaric, Fumaric (Males Age 13 and Over), Furan-2,5-dicarboxylic, Furan-2,5-dicarboxylic (Males Age 13 and Over), Furancarbonylglycine, Furancarbonylglycine (Males Age 13 and Over)), Glutaric, Glutaric (Males Age 13 and Over), Glyceric, Glyceric (Males Age 13 and Over), Glycolic, Glycolic (Males Age 13 and Over), Hippuric, Hippuric (Males Age 13 and Over), Homogentisic, Homogentisic (Males Age 13 and Over), Homovanillic (HVA), Homovanillic (HVA) (Males Age 13 and Over), HPHPA, HPHPA (Males Age 13 and Over), HVA / VMA Ratio, HVA / VMA Ratio (Males Age 13 and Over), HVA/ DOPAC Ratio, HVA/ DOPAC Ratio (Males Age 13 and Over), Kynurenic, Kynurenic (Males Age 13 and Over), Lactic, Lactic (Males Age 13 and Over), Malic, Malic (Males Age 13 and Over), Malonic, Malonic (Males Age 13 and Over), Mandelic, Mandelic (Males Age 13 and Over), Methylcitric, Methylcitric (Males Age 13 and Over), Methylmalonic, Methylmalonic (Males Age 13 and Over), Methylsuccinic, Methylsuccinic (Males Age 13 and Over), N-Acetylaspartic, N-Acetylaspartic (Males Age 13 and Over), N-Acetylcysteine (NAC), N-Acetylcysteine (NAC) (Males Age 13 and Over), Orotic, Orotic (Males Age 13 and Over), Oxalic, Oxalic (Males Age 13 and Over), Pantothenic (B5), Pantothenic (B5) (Males Age 13 and Over), Phenyllactic, Phenyllactic (Males Age 13 and Over), Phenylpyruvic, Phenylpyruvic (Males Age 13 and Over), Phosphoric, Phosphoric (Males Age 13 and Over), Pyridoxic (B6), Pyridoxic (B6) (Males Age 13 and Over), Pyroglutamic, Pyroglutamic (Males Age 13 and Over), Pyruvic, Pyruvic (Males Age 13 and Over), Quinolinic, Quinolinic (Males Age 13 and Over), Quinolinic / 5-HIAA Ratio, Sebacic, Sebacic (Males Age 13 and Over), Suberic, Suberic (Males Age 13 and Over), Succinic, Succinic (Males Age 13 and Over), Tartaric, Tartaric (Males Age 13 and Over), Thymine, Thymine (Males Age 13 and Over), Tricarballylic, Tricarballylic (Males Age 13 and Over), Uracil, Uracil (Males Age 13 and Over), Vanillylmandelic (VMA), Vanillylmandelic (VMA) (Males Age 13 and Over)