3-Hydroxy-3-methylglutaric is the precursor of coenzyme Q10 and cholesterol. Slightly increased values may be caused by gastrointestinal yeast overgrowth. A moderate increase in urine HMG may also indicate decreased synthesis of coenzyme Q10. Certain cholesterol-lowering drugs may inhibit the synthesis pathway and result in high HMG values. Very elevated values may be caused by the genetic disorder, HMG aciduria.
Understand and improve your laboratory results with our health dashboard.
Upload your lab reports and get your interpretation today.
Our technology helps to understand, combine, track, organize, and act on your medical lab test results.
- Precursor of CoQ10.
- Slightly elevated levels suggest yeast overgrowth.
- Elevated levels may also indicate decreased CoQ10 synthesis. Very elevated levels may be due to HMG aciduria.
--------------------------------------------------------------------
High 3-hydroxy-3-methylglutaric acid is seen in the genetic disease 3-hydroxy 3-methylglutaric aciduria.
Typical values observed in the genetic disease are 200-11,000 mmol/mol creatinine.
The cause of less significant increases in this urinary metabolite is unknown.
3-Hydroxy-3-methylglutaric aciduria may cause:
- vomiting,
- lethargy,
- hypotonia,
- and apnea,
...sometimes evolving to coma.
Laboratory tests reveal metabolic acidosis with severe hypoketotic hypoglycemia on fasting or during acute illness, hyperammonemia, and abnormal liver function.
Preliminary diagnosis is based on a pattern of organic acids in urine which includes:
- 3-hydroxy-3-methylglutaric,
- 3-hydroxyisovaleric,
- 3-methylglutaconic,
- 3-methylglutaric,
and 3-methylcrotonic acids.
Because yeast also produces this compound and yeast metabolites are frequently elevated along with this compound; slight increases may be yeast-related. Reduced activity of 3-hydroxy 3-methylglutaryl Co A reductase, a critical enzyme at the beginning of the cholesterol synthesis pathway, may also elevate this compound. Check cholesterol values when this compound is elevated up to 300 mmol/mol creatinine.
Slight elevations may result from coenzyme Q10 deficiency. Supplementation with coenzyme Q10 at 50 - 120 mg/day may be beneficial.
Interpret Your Lab Results
Upload your lab report, and we'll interpret and provide you with recommendations today.
Get StartedOur specialized data entry service is designed to seamlessly integrate your laboratory results into your private dashboard. Just send in your lab test results—whether it's an image or a file—and our skilled data entry team will handle the rest. We accommodate various file formats like PDFs, JPGs, and Excel.
The first report is complimentary. After that, the data entry service is priced at $15 per report, unless it's part of your subscribed plan. It's an ideal solution whether you have numerous reports to upload or if your schedule doesn't permit self-data entry.
We strive to make the data entry process easy for you. Whether by offering dozens of templates to choose from that pre-populate the most popular laboratory panels or by giving you instant feedback on the entered values. Our data entry forms are an easy, fast, and convenient way to enter the reports yourself. There is no limit on how many lab reports you can upload.
Personal plans
track personal results
Professional Plan
track multiple client's results
$15/month
$250/once
own it for life
$45/month
for health professionals
Personal Account
$15/month
for personal lab results
$250/once
own it for life
Level up your lab report analysis with our Pro plan, built for health practitioners like you.
Health Business Account
$45/month
Unlock additional Pro plans when you sign up.
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.
2-Hydroxybutyric, 2-Hydroxybutyric (Males Age 13 and Over), 2-Hydroxybutyric (Males Under Age 13), 2-Hydroxyhippuric, 2-Hydroxyhippuric (Females Under Age 13), 2-Hydroxyhippuric (Males Age 13 and Over), 2-Hydroxyhippuric (Males Under Age 13), 2-Hydroxyisocaproic, 2-Hydroxyisocaproic (Males Age 13 and Over), 2-Hydroxyisocaproic (Males Under Age 13), 2-Hydroxyisovaleric, 2-Hydroxyisovaleric (Males Age 13 and Over), 2-Hydroxyisovaleric (Males Under Age 13), 2-Hydroxyphenylacetic, 2-Hydroxyphenylacetic (Males Age 13 and Over), 2-Hydroxyphenylacetic (Males Under Age 13), 2-Oxo-4-methiolbutyric, 2-Oxo-4-methiolbutyric (Males Age 13 and Over), 2-Oxo-4-methiolbutyric (Males Under Age 13), 2-Oxoglutaric, 2-Oxoglutaric (Males Age 13 and Over), 2-Oxoglutaric (Males Under Age 13), 2-Oxoisocaproic, 2-Oxoisocaproic (Males Age 13 and Over), 2-Oxoisocaproic (Males Under Age 13), 2-Oxoisovaleric, 2-Oxoisovaleric (Males Age 13 and Over), 2-Oxoisovaleric (Males Under Age 13), 3-Hydroxy-3-methylglutaric (HMG), 3-Hydroxy-3-methylglutaric (Males Age 13 and Over), 3-Hydroxy-3-methylglutaric (Males Under Age 13), 3-Hydroxybutyric, 3-Hydroxybutyric (Males Age 13 and Over), 3-Hydroxybutyric (Males Under Age 13), 3-Hydroxyglutaric, 3-Hydroxyglutaric (Males Age 13 and Over), 3-Hydroxyglutaric (Males Under Age 13), 3-Indoleacetic, 3-Indoleacetic (Males Age 13 and Over), 3-Indoleacetic (Males Under Age 13), 3-Methyl-2-oxovaleric, 3-Methyl-2-oxovaleric (Males Age 13 and Over), 3-Methyl-2-oxovaleric (Males Under Age 13), 3-Methylglutaconic, 3-Methylglutaconic (Males Age 13 and Over), 3-Methylglutaconic (Males Under Age 13), 3-Methylglutaric, 3-Methylglutaric (Females Under Age 13), 3-Methylglutaric (Males Age 13 and Over), 3-Methylglutaric (Males Under Age 13), 3-Oxoglutaric, 3-Oxoglutaric (Males Age 13 and Over), 3-Oxoglutaric (Males Under Age 13), 4-Cresol, 4-Cresol (Males Age 13 and Over), 4-Cresol (Males Under Age 13), 4-Hydroxybenzoic, 4-Hydroxybenzoic (Males Age 13 and Over), 4-Hydroxybenzoic (Males Under Age 13), 4-Hydroxybutyric, 4-Hydroxybutyric (Females Under Age 13), 4-Hydroxybutyric (Males Age 13 and Over), 4-Hydroxybutyric (Males Under Age 13), 4-Hydroxyhippuric, 4-Hydroxyhippuric (Males Age 13 and Over), 4-Hydroxyhippuric (Males Under Age 13), 4-Hydroxyphenylacetic, 4-Hydroxyphenylacetic (Females Under Age 13), 4-Hydroxyphenylacetic (Males Age 13 and Over), 4-Hydroxyphenylacetic (Males Under Age 13), 4-Hydroxyphenyllactic, 4-Hydroxyphenyllactic (Males Age 13 and Over), 4-Hydroxyphenyllactic (Males Under Age 13), 5-Hydroxyindoleacetic (5-HIAA), 5-Hydroxyindoleacetic (5-HIAA) (Males Age 13 and Over), 5-Hydroxyindoleacetic (5-HIAA) (Males Under Age 13), 5-Hydroxymethyl-2-furoic, 5-Hydroxymethyl-2-furoic (Males Age 13 and Over), 5-Hydroxymethyl-2-furoic (Males Under Age 13), Acetoacetic, Acetoacetic (Males Age 13 and Over), Acetoacetic (Males Under Age 13), Aconitic, Aconitic (Males Age 13 and Over), Aconitic (Males Under Age 13), Adipic, Adipic (Males Age 13 and Over), Adipic (Males Under Age 13), Arabinose, Arabinose (Females Under Age 13), Arabinose (Males Age 13 and Over), Arabinose (Males Under Age 13), Ascorbic, Ascorbic (Males Age 13 and Over), Ascorbic (Males Under Age 13), Carboxycitric, Carboxycitric (Males Age 13 and Over), Carboxycitric (Males Under Age 13), Citramalic, Citramalic (Males Age 13 and Over), Citramalic (Males Under Age 13), Citric, Citric (Males Age 13 and Over), Citric (Males Under Age 13), DHPPA (Beneficial Bacteria), DHPPA (Beneficial Bacteria) (Males Age 13 and Over), DHPPA (Beneficial Bacteria) (Males Under Age 13), Dihydroxyphenylacetic (DOPAC), Dihydroxyphenylacetic (DOPAC) (Females Under Age 13), Dihydroxyphenylacetic (DOPAC) (Males Age 13 and Over), Dihydroxyphenylacetic (DOPAC) (Males Under Age 13), Ethylmalonic, Ethylmalonic (Males Age 13 and Over), Ethylmalonic (Males Under Age 13), Fumaric, Fumaric (Males Age 13 and Over), Fumaric (Males Under Age 13), Furan-2,5-dicarboxylic, Furan-2,5-dicarboxylic (Males Age 13 and Over), Furan-2,5-dicarboxylic (Males Under Age 13), Furancarbonylglycine, Furancarbonylglycine (Females Under Age 13), Furancarbonylglycine (Males Age 13 and Over), Furancarbonylglycine (Males Under Age 13), Glutaric, Glutaric (Females Under Age 13), Glutaric (Males Age 13 and Over), Glutaric (Males Under Age 13), Glyceric, Glyceric (Males Age 13 and Over), Glyceric (Males Under Age 13), Glycolic, Glycolic (Males Age 13 and Over), Glycolic (Males Under Age 13), Hippuric, Hippuric (Females Under Age 13), Hippuric (Males Age 13 and Over), Hippuric (Males Under Age 13), Homogentisic, Homogentisic (Males Age 13 and Over), Homogentisic (Males Under Age 13), Homovanillic (HVA), Homovanillic (HVA) (Males Age 13 and Over), Homovanillic (HVA) (Males Under Age 13), HPHPA, HPHPA (Males Age 13 and Over), HPHPA (Males Under Age 13), HVA / VMA Ratio, HVA / VMA Ratio (Males Age 13 and Over), HVA / VMA Ratio (Males Under Age 13), HVA/ DOPAC Ratio, HVA/ DOPAC Ratio (Males Age 13 and Over), HVA/ DOPAC Ratio (Males Under Age 13), Kynurenic, Kynurenic (Males Age 13 and Over), Kynurenic (Males Under Age 13), Lactic, Lactic (Males Age 13 and Over), Lactic (Males Under Age 13), Malic, Malic (Males Age 13 and Over), Malic (Males Under Age 13), Malonic, Malonic (Males Age 13 and Over), Malonic (Males Under Age 13), Mandelic, Mandelic (Males Age 13 and Over), Mandelic (Males Under Age 13), Methylcitric, Methylcitric (Males Age 13 and Over), Methylcitric (Males Under Age 13), Methylmalonic, Methylmalonic (Males Age 13 and Over), Methylmalonic (Males Under Age 13), Methylsuccinic, Methylsuccinic (Males Age 13 and Over), Methylsuccinic (Males Under Age 13), N-Acetylaspartic, N-Acetylaspartic (Males Age 13 and Over), N-Acetylaspartic (Males Under Age 13), N-Acetylcysteine (NAC), N-Acetylcysteine (NAC) (Males Age 13 and Over), N-Acetylcysteine (NAC) (Males Under Age 13), Orotic, Orotic (Females Under Age 13), Orotic (Males Age 13 and Over), Orotic (Males Under Age 13), Oxalic, Oxalic (Females Under Age 13), Oxalic (Males Age 13 and Over), Oxalic (Males Under Age 13), Pantothenic (B5), Pantothenic (B5) (Males Age 13 and Over), Pantothenic (B5) (Males Under Age 13), Phenyllactic, Phenyllactic (Males Age 13 and Over), Phenyllactic (Males Under Age 13), Phenylpyruvic, Phenylpyruvic (Males Age 13 and Over), Phenylpyruvic (Males Under Age 13), Phosphoric, Phosphoric (Males Age 13 and Over), Phosphoric (Males Under Age 13), Pyridoxic (B6), Pyridoxic (B6) (Males Age 13 and Over), Pyridoxic (B6) (Males Under Age 13), Pyroglutamic, Pyroglutamic (Males Age 13 and Over), Pyroglutamic (Males Under Age 13), Pyruvic, Pyruvic (Females Under Age 13), Pyruvic (Males Age 13 and Over), Pyruvic (Males Under Age 13), Quinolinic, Quinolinic (Males Age 13 and Over), Quinolinic (Males Under Age 13), Quinolinic / 5-HIAA Ratio, Sebacic, Sebacic (Males Age 13 and Over), Sebacic (Males Under Age 13), Suberic, Suberic (Males Age 13 and Over), Suberic (Males Under Age 13), Succinic, Succinic (Females Under Age 13), Succinic (Males Age 13 and Over), Succinic (Males Under Age 13), Tartaric, Tartaric (Males Age 13 and Over), Tartaric (Males Under Age 13), Thymine, Thymine (Males Age 13 and Over), Thymine (Males Under Age 13), Tricarballylic, Tricarballylic (Females Under Age 13), Tricarballylic (Males Age 13 and Over), Tricarballylic (Males Under Age 13), Uracil, Uracil (Males Age 13 and Over), Uracil (Males Under Age 13), Vanillylmandelic (VMA), Vanillylmandelic (VMA) (Males Age 13 and Over), Vanillylmandelic (VMA) (Males Under Age 13)