Organic Acids Test (The Great Plains Laboratory)

3-Methylglutaconic (Males Age 13 and Over)

Optimal Result: 0.38 - 2 mmol/mol creatinine.

3-Methylglutaconic acid is an organic acid. Abnormally high levels of organic acids in the blood (organic acidemia), urine (organic aciduria), the brain, and other tissues lead to general metabolic acidosis. Acidosis typically occurs when arterial pH falls below 7.35. In infants with acidosis, the initial symptoms include poor feeding, vomiting, loss of appetite, weak muscle tone (hypotonia), and lack of energy (lethargy). These can progress to heart, liver, and kidney abnormalities, seizures, coma, and possibly death. These are also the characteristic symptoms of the untreated IEMs mentioned above. Many affected children with organic acidemias experience intellectual disability or delayed development. In adults, acidosis or acidemia is characterized by headaches, confusion, feeling tired, tremors, sleepiness, and seizures.

Reference: https://hmdb.ca/metabolites/HMDB000052

What does it mean if your 3-Methylglutaconic (Males Age 13 and Over) result is too high?

Elevated levels may indicate a reduced ability to metabolize leucine.

The marker, 3-methylglutaconic acid in high values indicates a reduced ability to metabolize the amino acid, leucine. This abnormality is found in the genetic disease, methylglutaconic aciduria and in mitochondrial disorders.

Consider supplementation with CoQ10, niacin, carnitine, riboflavin, nicotinaminde, biotin, and Vitamin E.

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