Organic Acids Test (OAT) - Nutritional and Metabolic Profile

Thymine

Optimal result: 0 – 0.56 mmol/mol creatinine

Mosaic Diagnostics

By Healthmatters Editorial Team

Peer-reviewed sources

- Slightly elevated urinary thymine has no clinical significance.
- High values are associated with inflammatory diseases and cancer.

Elevated pyrimidines and elevated thymine have been reported in dihydropyrimidine dehydrogenase deficiency, a rare genetic disease, which has been associated with seizures and autism.

A pyrimidine (DNA building block) that is elevated in the genetic disease dihydropyrimidine dehydrogenase deficiency. In this genetic disease, the pyrimidine uracil is also elevated.

- Thymine is one of the five bases used to build nucleic acids.
- It is also known as 5-methyluracil or by the abbreviations T or Thy.
- Thymine is found in DNA, where it pairs with adenine via two hydrogen bonds. In RNA, thymine is replaced by uracil.

Thymine is one of the four Pyrimidines/nucleobases in the nucleic acid of DNA that are represented by the letters G–C–A–T.

Uracil = 2,4-dioxy pyrimidine
Thymine = 2,4-dioxy-5-methyl pyrimidine
Cytosine = 2-oxy-4-amino pyrimidine
Orotic acid = 2,4-dioxy-6-carboxy pyrimidine

Cytosine is found in both DNA and RNA. Uracil is found only in RNA. Thymine is normally found in DNA. Sometimes tRNA will contain some thymine as well as uracil.

Thymine is also called 5-methyluracil or it may be represented by the capital letter "T" or by its three-letter abbreviation, Thy.

The molecule gets its name from its initial isolation from calf thymus glands by Albrecht Kossel and Albert Neumann in 1893. Thymine is found in both prokaryotic and eukaryotic cells, but it does not occur in RNA viruses.

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