The organic acids test by Great Plains Laboratory measures a few oxalate metabolites which can determine if someone has high oxalate levels. These include oxalic, glycolic, and glyceric.
In humans and in yeast, glyoxalate is the parent compound that can be converted into the three metabolites measured on the Organic Acids Test (OAT): glyceric, glycolic, and oxalic acid.
Normal values rule out genetic causes of significantly elevated urinary oxalic acid.
- High glyceric levels on an organic acids test usually relates to primary hyperoxaluria type 2. In this condition there is a deficiency of glyoxylate reductase/hydroxypyruvate reductase (GRHFR). Whereas primary hyperoxaluria type 1 can lead to kidney failure, primary hyperoxaluria type 2 is more likely to cause the formation of kidney stones.
- Elevated levels of glyceric acid in addition to an elevation in oxalates on the OAT test indicates the presence of the type 2 GRHPR genetic variance.
- Elevated values may also be due to microbial sources such as yeast (Aspergillus, Penicillium, probably Candida) or due to dietary sources containing glycerol (glycerine). Glyceric acid is isolated from various plants (e.g. brassicas, pulses, and Vicia faba).
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