Citramalic Acid is a metabolite of yeast or anaerobic bacteria, including Clostridia.
Citramalic acid is an analog of malic acid. The structure of citramalic acid is similar to the structure of malic acid except it has an extra CH3 group on it. It can inhibit the production of malic acid. Citramalic acid has been found to be a byproduct of Saccharomyces yeast species, as well as Propionibacterium acnes.
Understand and improve your laboratory results with our health dashboard.
Upload your lab reports and get interpretation today.
Our technology helps to understand, combine, track, organize, and act on your medical lab test results.
If your citramalic acid is elevated it could mean that there is yeast or anaerobic bacterial overgrowth.
Elevated citramalic acid is produced mainly by Saccharomyces species or Propionibacteria overgrowth.
With a chemical structure very similar to that of malic acid, citramalate may cause metabolic interference with malate. This is of concern because malic acid has extra-mitochondrial functions, as with the "malate shuttle" for carrying reducing equivalents (protons) into the mitochondria. While the metabolic interference aspect is uncertain, the presence of citramalate in the urine indicates intestinal dysbiosis. Not formed in human tissues, citramalate may be formed by anaerobic bacteria such as clostridia, as well as by yeast/fungi. A stool analysis with bacteriology or microbiology is suggested.
Additional investigations:
Citramalic acid is a general indicator of excess yeast in your system. In order to determine if this is due to normal flora (Saccharomyces) or imbalanced flora, consider a comprehensive stool analysis and GI Effects test.
Treatment considerations:
- Antifungals or antimicrobials
- Yeast free diet
- Probiotics: High-potency multi-strain probiotics may help rebalance GI flora.
Interpret Your Lab Results
Upload your lab report and we’ll interpret and provide you with recomendations today.
Get StartedGet Started With Our Personal Plan
Advanced Plan
Unlimited Plan
Are You a Health Professional?
Get started with our professional plan
Welcome to Healthmatters Pro.
Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place. Learn more
Pro Plan
for health professionals
$45 per month
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.
2-Hydroxybutyric, 2-Hydroxybutyric (Males Age 13 and Over), 2-Hydroxyhippuric, 2-Hydroxyhippuric (Males Age 13 and Over), 2-Hydroxyisocaproic, 2-Hydroxyisocaproic (Males Age 13 and Over), 2-Hydroxyisovaleric, 2-Hydroxyisovaleric (Males Age 13 and Over), 2-Hydroxyphenylacetic, 2-Hydroxyphenylacetic (Males Age 13 and Over), 2-Oxo-4-methiolbutyric, 2-Oxo-4-methiolbutyric (Males Age 13 and Over), 2-Oxoglutaric, 2-Oxoglutaric (Males Age 13 and Over), 2-Oxoisocaproic, 2-Oxoisocaproic (Males Age 13 and Over), 2-Oxoisovaleric, 2-Oxoisovaleric (Males Age 13 and Over), 3-Hydroxy-3-methylglutaric (HMG), 3-Hydroxy-3-methylglutaric (Males Age 13 and Over), 3-Hydroxybutyric, 3-Hydroxybutyric (Males Age 13 and Over), 3-Hydroxyglutaric, 3-Hydroxyglutaric (Males Age 13 and Over), 3-Indoleacetic, 3-Indoleacetic (Males Age 13 and Over), 3-Methyl-2-oxovaleric, 3-Methyl-2-oxovaleric (Males Age 13 and Over), 3-Methylglutaconic, 3-Methylglutaconic (Males Age 13 and Over), 3-Methylglutaric, 3-Methylglutaric (Males Age 13 and Over), 3-Oxoglutaric, 3-Oxoglutaric (Males Age 13 and Over), 4-Cresol, 4-Cresol (Males Age 13 and Over), 4-Hydroxybenzoic, 4-Hydroxybenzoic (Males Age 13 and Over), 4-Hydroxybutyric, 4-Hydroxybutyric (Males Age 13 and Over), 4-Hydroxyhippuric, 4-Hydroxyhippuric (Males Age 13 and Over), 4-Hydroxyphenylacetic, 4-Hydroxyphenylacetic (Males Age 13 and Over), 4-Hydroxyphenyllactic, 4-Hydroxyphenyllactic (Males Age 13 and Over), 5-Hydroxyindoleacetic (5-HIAA), 5-Hydroxyindoleacetic (5-HIAA) (Males Age 13 and Over), 5-Hydroxymethyl-2-furoic, 5-Hydroxymethyl-2-furoic (Males Age 13 and Over), Acetoacetic, Acetoacetic (Males Age 13 and Over), Aconitic, Aconitic (Males Age 13 and Over), Adipic, Adipic (Males Age 13 and Over), Arabinose, Arabinose (Males Age 13 and Over), Ascorbic, Ascorbic (Males Age 13 and Over), Carboxycitric, Carboxycitric (Males Age 13 and Over), Citramalic, Citramalic (Males Age 13 and Over), Citric, Citric (Males Age 13 and Over), DHPPA (Beneficial Bacteria), DHPPA (Beneficial Bacteria) (Males Age 13 and Over), Dihydroxyphenylacetic (DOPAC), Dihydroxyphenylacetic (DOPAC) (Males Age 13 and Over), Ethylmalonic, Ethylmalonic (Males Age 13 and Over), Fumaric, Fumaric (Males Age 13 and Over), Furan-2,5-dicarboxylic, Furan-2,5-dicarboxylic (Males Age 13 and Over), Furancarbonylglycine, Furancarbonylglycine (Males Age 13 and Over)), Glutaric, Glutaric (Males Age 13 and Over), Glyceric, Glyceric (Males Age 13 and Over), Glycolic, Glycolic (Males Age 13 and Over), Hippuric, Hippuric (Males Age 13 and Over), Homogentisic, Homogentisic (Males Age 13 and Over), Homovanillic (HVA), Homovanillic (HVA) (Males Age 13 and Over), HPHPA, HPHPA (Males Age 13 and Over), HVA / VMA Ratio, HVA / VMA Ratio (Males Age 13 and Over), HVA/ DOPAC Ratio, HVA/ DOPAC Ratio (Males Age 13 and Over), Kynurenic, Kynurenic (Males Age 13 and Over), Lactic, Lactic (Males Age 13 and Over), Malic, Malic (Males Age 13 and Over), Malonic, Malonic (Males Age 13 and Over), Mandelic, Mandelic (Males Age 13 and Over), Methylcitric, Methylcitric (Males Age 13 and Over), Methylmalonic, Methylmalonic (Males Age 13 and Over), Methylsuccinic, Methylsuccinic (Males Age 13 and Over), N-Acetylaspartic, N-Acetylaspartic (Males Age 13 and Over), N-Acetylcysteine (NAC), N-Acetylcysteine (NAC) (Males Age 13 and Over), Orotic, Orotic (Males Age 13 and Over), Oxalic, Oxalic (Males Age 13 and Over), Pantothenic (B5), Pantothenic (B5) (Males Age 13 and Over), Phenyllactic, Phenyllactic (Males Age 13 and Over), Phenylpyruvic, Phenylpyruvic (Males Age 13 and Over), Phosphoric, Phosphoric (Males Age 13 and Over), Pyridoxic (B6), Pyridoxic (B6) (Males Age 13 and Over), Pyroglutamic, Pyroglutamic (Males Age 13 and Over), Pyruvic, Pyruvic (Males Age 13 and Over), Quinolinic, Quinolinic (Males Age 13 and Over), Quinolinic / 5-HIAA Ratio, Sebacic, Sebacic (Males Age 13 and Over), Suberic, Suberic (Males Age 13 and Over), Succinic, Succinic (Males Age 13 and Over), Tartaric, Tartaric (Males Age 13 and Over), Thymine, Thymine (Males Age 13 and Over), Tricarballylic, Tricarballylic (Males Age 13 and Over), Uracil, Uracil (Males Age 13 and Over), Vanillylmandelic (VMA), Vanillylmandelic (VMA) (Males Age 13 and Over)