Optimal Result: 0.06 - 1.8 mmol/mol creatinine.

Malic Acid is involved in the citric acid cycle (aka. Krebs cycle). The citric acid cycle is a series of reactions that occur in the mitochondrion to generate chemical energy that fuels the metabolism. This cycle critically supports organ maintenance and neurological function.

What does it mean if your Malic result is too low?

- A deficiency in one or more Krebs’ cycle intermediates and an inhibition of normal energy production may cause a wide range of metabolic disturbances and symptoms.

- Low levels can indicate a general amino acid insufficiency.

What does it mean if your Malic result is too high?

- Higher levels of malic acid in urine indicates inefficiencies in energy production.

- Elevated malic acid values suggest increased need for niacin and CoQ10.

- When malic acid is simultaneously elevated with citric, fumaric, and alpha-ketoglutaric acids, it strongly suggests cytochrome C oxidase deficiency, indicating dysfunction in the mitochondrial energy pathways.

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