It is a metabolite of phenylalanine and is excreted in the urine of patients suffering from diseases like phenylketonuria.
2-Hydroxyphenylacetic acid may be an indication of SIBO. It also becomes elevated with Giardia.
Elevated 2-hydroxyphenylacetic acid is associated with intestinal bacteria overgrowth.
- Excessive phenylaline (dietary or PKU) or tyrosine
- Reduced oxygenation (Fe deficiency, anemia, pulmonary disorder)
- Low tetrahydrobiopterin (BH4) - an essential cofactor for phenylaline, tyrosine, tryptophan & nitric oxide
- Urinary Amino Acids
- Iron Studies
- Rule out excessive phenylaline & or tyrosine
- Address oxygenation (correct anemia, pulmonary problems, cardiac insufficiency)
- Supplement vitamin C (increases BH4 levels in the body)
- 5-MTHF (from folic acid) may help nitric oxide production when BH4 is low
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