Organic Acids Test (OAT) - Nutritional and Metabolic Profile

Uracil (Males Age 13 and Over)

Optimal result: 0 – 6.9 mmol/mol creatinine

Mosaic Diagnostics

By Healthmatters Editorial Team

Peer-reviewed sources

- Because folic acid is involved as a methyl donor in the conversion of uracil to thymine, elevated uracil may indicate a defect in folic acid metabolism.

- High levels of Uracil can indicate a folate deficiency, it can also indicate methylation problems and this is more likely to be an issue for people with the MTHFR gene mutation.

- Elevated uracil is found in about 10% of children with autism.

- If Uracil is high consider additional L-Methyl-Folate supplementation, i.e. 500mcg to 1000mcg daily.

The pyrimidine metabolites are markers of folate metabolism. The two markers are uracil and thymine. Folate acts as a methyl donor in converting uracil to thymine.

Elevated values of uracil suggest folic acid deficiency. Folate is needed to convert uracil to thymine by methylation.

Levels of pyrimidine metabolites (uracil and thymine) reflect how well the body is metabolizing folate.

A body deficient in folate (vitamin B9) has high uracil levels. Other causes of high uracil levels include mutations to the MTHFR homozygous gene and issues with methylation.

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Uracil (Males Age 13 and Over)

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