A healthy result should fall into the range 0 - 0.21 mmol/mol creatinine.

Mandelic acid is the major metabolite of styrene. Styrene (vinylbenzene) is used as an intermediate in plastic synthesis. Values less than 5 mg/L are due to normal metabolism of phenylalanine or tyrosine.

High concentrations of styrene cause:

- central nervous system depression,

- nausea,

- headache,

- fatigue,

- and liver damage.

When exposed to 100 ppm of styrene in air, mandelic acid in urine was found to average 1700 mmol/mol creatinine. Mandelic acid is also a metabolite of ethylbenzene, and some antispasmodic and vasodilator drugs. High values of mandelic acid also occur in phenylketonuria (PKU). Normal values of phenyllactic and phenylpyruvic acids may rule out PKU; a mild or heterozygous form of PKU might be present.

Measuring serum phenylalanine will rule out PKU.

Other causes may be increased dietary phenylalanine or phenylalanine supplements. Normal phenyllactic and phenylpyruvic acids indicate that styrene or drug exposure is more likely than PKU as a cause of these abnormalities. Dopamine metabolism is a target for the neurotoxic effects of some monocyclic aromatic hydrocarbons and their metabolites.

How to reduce exposure to styrene:

Reduce exposure by eliminating plastic and styrofoam containers for cooking, reheating, eating or drinking (especially warm or hot) food or beverages. Replace these containers with glass, paper, or stainless steel whenever possible.

Elimination of styrene can be accelerated by sauna treatment, reduced glutathione supplementation (oral, intravenous, transdermal, precursors such as N-acetyl cysteine [NAC]).

Ascorbic acid deficiency may also be related to this abnormality since ascorbic acid is a cofactor for phenylalanine hydroxylase. Supplementation with ascorbic acid (vitamin C) at 1000 mg/day or more may be beneficial.

References:

https://pubmed.ncbi.nlm.nih.gov/1273564/

Mandelic result calculator

insert the value from you Mandelic test result.

What does it mean if your Mandelic result is too high?

- Significant elevation is found in the genetic disorder, phenylketonuria (PKU). A plasma phenylalanine test will rule out PKU.

- Slight elevations by dietary phenylalanine or phenylalanine supplementation, but also due to exposure to styrene, a toxic environmental compound.

WE SUPPORT 1000+ BIOMARKERS INCLUDING BIOMARKERS FROM YOUR FAVOURITE LABS

Are you concerned about your lab report?
Select your plan, upload your lab reports and we’ll provide you with a meaningful interpretation.

Basic Interpretation
  • Instant interpretation
  • Use self upload form
  • 1000+ biomarkers explained
  • Nutrition Recommendations
  • Cancel anytime
Full Interpretation
  • Instant interpretation
  • We upload 4 reports for you
  • 1000+ biomarkers explained
  • Nutrition Recommendations
  • Cancel anytime
  • Online support
Own It For Life
  • Unlimited access
  • No subscription
  • Instant interpretations
  • We upload 10 reports for you
  • 1000+ biomarkers explained
  • Nutrition Recommendations
  • Dedicated support

Test results don't lie. Learn what is happening inside your body.

Health is not exactly rocket science. You just have to know what your body needs and doesn't need. Your medical tests contain that information. Upload them to our service and we’ll help you understand, organize, and act on them.

Get Started

Medical results explained and interpreted.
Healthmatters.io customer review

"I was really concerned about my lab results and my GP was not able to see me for another week. Through HealthMatters I was able to interpret my results instantly."

Healthmatters.io thankfull female customer

"I've been keeping all my lab results in a spreadsheet, covering approximately 20 years. The HealthMatters team helped me upload that info into the cloud. I can show this data to my family and doctors now easily."

Healthmatters.io thankful young female customer

"I had no idea what my lab results meant. Here I found all the biomarkers that I was looking for online. Finally, I have not only organized them all neatly in one place, but I am also grateful to be able to understand what they mean."



Pricing
Privacy and security of personal data. HIPAA and GDPR compliant badges.

Your Privacy And Security

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put security measures in place to help protect against the loss, misuse or alteration of information under our control. We use procedural, physical and electronic security methods designed to prevent people who aren't authorized from getting access to this information. Our internal code of conduct adds additional privacy protection. See our Privacy Policy for more information.