3-Hydroxy-3-methylglutaric (HMG)

Optimal Result: 0.17 - 39 mmol/mol creatinine.

Organic Acids Test (OAT) - Nutritional and Metabolic Profile Mosaic Diagnostics

From Healthmatters.io Team

Lab Results Explained and Tracked

3-Hydroxy-3-methylglutaric is the precursor of coenzyme Q10 and cholesterol. Slightly increased values may be caused by gastrointestinal yeast overgrowth. A moderate increase in urine HMG may also indicate decreased synthesis of coenzyme Q10. Certain cholesterol-lowering drugs may inhibit the synthesis pathway and result in high HMG values. Very elevated values may be caused by the genetic disorder, HMG aciduria.

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What does it mean if your 3-Hydroxy-3-methylglutaric (HMG) result is too high?

- Precursor of CoQ10.

- Slightly elevated levels suggest yeast overgrowth.

- Elevated levels may also indicate decreased CoQ10 synthesis. Very elevated levels may be due to HMG aciduria.

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High 3-hydroxy-3-methylglutaric acid is seen in the genetic disease 3-hydroxy 3-methylglutaric aciduria.

Typical values observed in the genetic disease are 200-11,000 mmol/mol creatinine.

The cause of less significant increases in this urinary metabolite is unknown.

3-Hydroxy-3-methylglutaric aciduria may cause:

- vomiting,

- lethargy,

- hypotonia,

- and apnea,

...sometimes evolving to coma.

Laboratory tests reveal metabolic acidosis with severe hypoketotic hypoglycemia on fasting or during acute illness, hyperammonemia, and abnormal liver function.

Preliminary diagnosis is based on a pattern of organic acids in urine which includes:

- 3-hydroxy-3-methylglutaric,

- 3-hydroxyisovaleric,

- 3-methylglutaconic,

- 3-methylglutaric,

and 3-methylcrotonic acids.

Because yeast also produces this compound and yeast metabolites are frequently elevated along with this compound; slight increases may be yeast-related. Reduced activity of 3-hydroxy 3-methylglutaryl Co A reductase, a critical enzyme at the beginning of the cholesterol synthesis pathway, may also elevate this compound. Check cholesterol values when this compound is elevated up to 300 mmol/mol creatinine.

Slight elevations may result from coenzyme Q10 deficiency. Supplementation with coenzyme Q10 at 50 - 120 mg/day may be beneficial.

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3-Hydroxy-3-methylglutaric (HMG)

All Your Lab Results. One Simple Dashboard.

What does it mean if your 3-Hydroxy-3-methylglutaric (HMG) result is too high?

All Your Lab Results. One Simple Dashboard.

Import, Track, and Share Your Lab Results Easily

Import, Track, and Share Your Lab Results

Article Review & Sources

Bring All Your Lab Results Together — In One Place

Gather Your Lab History — and Finally Make Sense of It

Finally, Your Lab Results Organized and Clear

Advanced Plan

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What's included in a Healthmatters membership

Import Lab Results from Any Source

See Your Health Timeline

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Visualize Your Results

Export Your Complete Lab History in a Single File Export Your Complete Lab History

Comprehensive Data Entry Service for Your Reports Data Entry Service for Your Reports

Securely Share With Anyone You Trust

Let Your Lab Results Tell the Full Story

Once your results are in one place, see the bigger picture — track trends over time, compare data side by side, export your full history, and share securely with anyone you trust.

Bring all your results together to compare, track progress, export your history, and share securely.

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