Methylsuccinic (Males Age 13 and Over)

Optimal Result: 0 - 2.3 mmol/mol creatinine.

Methylsuccinic acid is a normal metabolite found in human fluids and is an intermediate metabolite in the breakdown of fatty acids. Increased urinary levels of methylsuccinic acid (together with ethylmalonic acid) are the main biochemical measurable features in ethylmalonic encephalopathy.


References:

- https://pubmed.ncbi.nlm.nih.gov/29555466/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493831/
- https://pubmed.ncbi.nlm.nih.gov/20978941/
- https://pubmed.ncbi.nlm.nih.gov/12382164/
- https://pubmed.ncbi.nlm.nih.gov/22424739/
- https://pubmed.ncbi.nlm.nih.gov/18054510/
- https://pubmed.ncbi.nlm.nih.gov/7776094/
- https://pubmed.ncbi.nlm.nih.gov/7360517/
- https://pubmed.ncbi.nlm.nih.gov/10723193/
- https://pubmed.ncbi.nlm.nih.gov/7145508/
- https://pubmed.ncbi.nlm.nih.gov/19343532/
- https://pubmed.ncbi.nlm.nih.gov/19343532/
- https://pubmed.ncbi.nlm.nih.gov/6452974/
- https://pubmed.ncbi.nlm.nih.gov/2109491/

What does it mean if your Methylsuccinic (Males Age 13 and Over) result is too high?

Increased urinary levels of methylsuccinic acid (together with ethylmalonic acid) are the main biochemical measurable features in ethylmalonic encephalopathy, a rare metabolic disorder with an autosomal recessive mode of inheritance that is clinically characterized by neuromotor delay, hyperlactic acidemia, recurrent petechiae, orthostatic acrocyanosis, and chronic diarrhea. The underlying biochemical defect involves isoleucine catabolism. 

Other inborn errors:

Moreover, methylsuccinic acid is found to be associated with isovaleric acidemia, and medium-chain acyl-CoA dehydrogenase deficiency, which are also inborn errors of metabolism.

High Methylsuccinic levels may also be due to:

- carnitine deficiency, 
- fasting, 
- increased intake of the medium-chain triglycerides found in coconut oil, MCT oil, and some infant formulas. 

Regardless of cause, supplementation with L-carnitine or acetyl-L-carnitine (500-1000 mg per day) may be beneficial.

10 000+ happy customers
100% satisfaction
★ ★ ★ ★ ★ customer support

Trust us to examine your lab results, guiding you towards improved health.

Use promo code to save 10% off any plan.


We implement proven measures to keep your data safe.

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.