HPHPA stands for 3-(3-hydroxyphenyl)-3-hydroxypropionic acid.
The source of this compound appears to be multiple species of anaerobic bacteria of the Clostridium genus.
The biochemical role of Clostridia in altering brain neurotransmitters is due to the fact that Clostridia metabolites inactivate dopamine beta-hydroxylase, leading to an excess production of brain dopamine and reduced levels of the neurotransmitter norepinephrine. Excess dopamine is associated with abnormal or psychotic behavior. This imbalance can be demonstrated in the Organic Acids Urine Test by observing the ratio of the major dopamine metabolite, homovanillic acid (HVA), to that of the major norepinephrine metabolite, vanillylmandelic acid (VMA) when the Clostridia marker HPHPA is elevated.
The highest value of HPHPA was measured in the urine of a young woman with first onset of schizophrenia. Treatment of Clostridia bacteria resulted in loss of auditory hallucinations. In autism, children with gastrointestinal Clostridia commonly exhibit aggressive behavior, agitation, obsessive compulsive behavior, and irritability. They may have very foul stools with diarrhea with mucus in the stools although some individuals may be constipated. Stool testing for Clostridia is usually of limited usefulness since most Clostridia species are considered probiotics or beneficial. There are about 100 species of Clostridia that are commonly found in the gastrointestinal tract. Only seven of these species are producers of HPHPA including C. sporogenes, C.botulinum, C. caloritolerans, C. angenoti, C. ghoni, C.bifermentans, C. difficile, and C. sordellii while C. tetani,C. sticklandii, C. lituseburense, C. subterminale, C.putifaciens, C. propionicum, C. malenomenatum, C.limosum, C. lentoputrescens, C. tetanomorphum, C.coclearium, C. histolyticum, C. aminovalericum, and C.sporospheroides do not produce compounds that are converted to HPHPA.
References:
- https://www.ncbi.nlm.nih.gov/pubmed/20423563
- https://www.tandfonline.com/doi/abs/10.1179/147683010X12611460763968
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HPHPA elevated values indicate overgrowth of Clostridia in the GI tract including C. sporogenes, C. caloritolerans, and C. botulinum. This metabolite is commonly elevated in GAPS cases (=Gut and Psychology Syndrome). It inhibits the enzyme , leading to neurotransmitter imbalances.
HPHPA causes deactivation of an enzyme called dopamine-beta-hydroxylase so that dopamine cannot be converted to the neurotransmitter neuroepinephrine, and that causes a build-up of dopamine.
The major clinical impact that has been observed in patients with elevated HPHPA (as well as another clostridia bacteria toxin called 4-Cresol), particularly in individuals on the autism-spectrum, is erratic, aggressive and self-injurious behavior. Sometimes these behaviors are so severe the person is heavily medicated in attempts to control the problems. [L]
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I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
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As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
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2-Hydroxybutyric, 2-Hydroxybutyric (Males Age 13 and Over), 2-Hydroxybutyric (Males Under Age 13), 2-Hydroxyhippuric, 2-Hydroxyhippuric (Females Under Age 13), 2-Hydroxyhippuric (Males Age 13 and Over), 2-Hydroxyhippuric (Males Under Age 13), 2-Hydroxyisocaproic, 2-Hydroxyisocaproic (Males Age 13 and Over), 2-Hydroxyisocaproic (Males Under Age 13), 2-Hydroxyisovaleric, 2-Hydroxyisovaleric (Males Age 13 and Over), 2-Hydroxyisovaleric (Males Under Age 13), 2-Hydroxyphenylacetic, 2-Hydroxyphenylacetic (Males Age 13 and Over), 2-Hydroxyphenylacetic (Males Under Age 13), 2-Oxo-4-methiolbutyric, 2-Oxo-4-methiolbutyric (Males Age 13 and Over), 2-Oxo-4-methiolbutyric (Males Under Age 13), 2-Oxoglutaric, 2-Oxoglutaric (Males Age 13 and Over), 2-Oxoglutaric (Males Under Age 13), 2-Oxoisocaproic, 2-Oxoisocaproic (Males Age 13 and Over), 2-Oxoisocaproic (Males Under Age 13), 2-Oxoisovaleric, 2-Oxoisovaleric (Males Age 13 and Over), 2-Oxoisovaleric (Males Under Age 13), 3-Hydroxy-3-methylglutaric (HMG), 3-Hydroxy-3-methylglutaric (Males Age 13 and Over), 3-Hydroxy-3-methylglutaric (Males Under Age 13), 3-Hydroxybutyric, 3-Hydroxybutyric (Males Age 13 and Over), 3-Hydroxybutyric (Males Under Age 13), 3-Hydroxyglutaric, 3-Hydroxyglutaric (Males Age 13 and Over), 3-Hydroxyglutaric (Males Under Age 13), 3-Indoleacetic, 3-Indoleacetic (Males Age 13 and Over), 3-Indoleacetic (Males Under Age 13), 3-Methyl-2-oxovaleric, 3-Methyl-2-oxovaleric (Males Age 13 and Over), 3-Methyl-2-oxovaleric (Males Under Age 13), 3-Methylglutaconic, 3-Methylglutaconic (Males Age 13 and Over), 3-Methylglutaconic (Males Under Age 13), 3-Methylglutaric, 3-Methylglutaric (Females Under Age 13), 3-Methylglutaric (Males Age 13 and Over), 3-Methylglutaric (Males Under Age 13), 3-Oxoglutaric, 3-Oxoglutaric (Males Age 13 and Over), 3-Oxoglutaric (Males Under Age 13), 4-Cresol, 4-Cresol (Males Age 13 and Over), 4-Cresol (Males Under Age 13), 4-Hydroxybenzoic, 4-Hydroxybenzoic (Males Age 13 and Over), 4-Hydroxybenzoic (Males Under Age 13), 4-Hydroxybutyric, 4-Hydroxybutyric (Females Under Age 13), 4-Hydroxybutyric (Males Age 13 and Over), 4-Hydroxybutyric (Males Under Age 13), 4-Hydroxyhippuric, 4-Hydroxyhippuric (Males Age 13 and Over), 4-Hydroxyhippuric (Males Under Age 13), 4-Hydroxyphenylacetic, 4-Hydroxyphenylacetic (Females Under Age 13), 4-Hydroxyphenylacetic (Males Age 13 and Over), 4-Hydroxyphenylacetic (Males Under Age 13), 4-Hydroxyphenyllactic, 4-Hydroxyphenyllactic (Males Age 13 and Over), 4-Hydroxyphenyllactic (Males Under Age 13), 5-Hydroxyindoleacetic (5-HIAA), 5-Hydroxyindoleacetic (5-HIAA) (Males Age 13 and Over), 5-Hydroxyindoleacetic (5-HIAA) (Males Under Age 13), 5-Hydroxymethyl-2-furoic, 5-Hydroxymethyl-2-furoic (Males Age 13 and Over), 5-Hydroxymethyl-2-furoic (Males Under Age 13), Acetoacetic, Acetoacetic (Males Age 13 and Over), Acetoacetic (Males Under Age 13), Aconitic, Aconitic (Males Age 13 and Over), Aconitic (Males Under Age 13), Adipic, Adipic (Males Age 13 and Over), Adipic (Males Under Age 13), Arabinose, Arabinose (Females Under Age 13), Arabinose (Males Age 13 and Over), Arabinose (Males Under Age 13), Ascorbic, Ascorbic (Males Age 13 and Over), Ascorbic (Males Under Age 13), Carboxycitric, Carboxycitric (Males Age 13 and Over), Carboxycitric (Males Under Age 13), Citramalic, Citramalic (Males Age 13 and Over), Citramalic (Males Under Age 13), Citric, Citric (Males Age 13 and Over), Citric (Males Under Age 13), DHPPA (Beneficial Bacteria), DHPPA (Beneficial Bacteria) (Males Age 13 and Over), DHPPA (Beneficial Bacteria) (Males Under Age 13), Dihydroxyphenylacetic (DOPAC), Dihydroxyphenylacetic (DOPAC) (Females Under Age 13), Dihydroxyphenylacetic (DOPAC) (Males Age 13 and Over), Dihydroxyphenylacetic (DOPAC) (Males Under Age 13), Ethylmalonic, Ethylmalonic (Males Age 13 and Over), Ethylmalonic (Males Under Age 13), Fumaric, Fumaric (Males Age 13 and Over), Fumaric (Males Under Age 13), Furan-2,5-dicarboxylic, Furan-2,5-dicarboxylic (Males Age 13 and Over), Furan-2,5-dicarboxylic (Males Under Age 13), Furancarbonylglycine, Furancarbonylglycine (Females Under Age 13), Furancarbonylglycine (Males Age 13 and Over), Furancarbonylglycine (Males Under Age 13), Glutaric, Glutaric (Females Under Age 13), Glutaric (Males Age 13 and Over), Glutaric (Males Under Age 13), Glyceric, Glyceric (Males Age 13 and Over), Glyceric (Males Under Age 13), Glycolic, Glycolic (Males Age 13 and Over), Glycolic (Males Under Age 13), Hippuric, Hippuric (Females Under Age 13), Hippuric (Males Age 13 and Over), Hippuric (Males Under Age 13), Homogentisic, Homogentisic (Males Age 13 and Over), Homogentisic (Males Under Age 13), Homovanillic (HVA), Homovanillic (HVA) (Males Age 13 and Over), Homovanillic (HVA) (Males Under Age 13), HPHPA, HPHPA (Males Age 13 and Over), HPHPA (Males Under Age 13), HVA / VMA Ratio, HVA / VMA Ratio (Males Age 13 and Over), HVA / VMA Ratio (Males Under Age 13), HVA/ DOPAC Ratio, HVA/ DOPAC Ratio (Males Age 13 and Over), HVA/ DOPAC Ratio (Males Under Age 13), Kynurenic, Kynurenic (Males Age 13 and Over), Kynurenic (Males Under Age 13), Lactic, Lactic (Males Age 13 and Over), Lactic (Males Under Age 13), Malic, Malic (Males Age 13 and Over), Malic (Males Under Age 13), Malonic, Malonic (Males Age 13 and Over), Malonic (Males Under Age 13), Mandelic, Mandelic (Males Age 13 and Over), Mandelic (Males Under Age 13), Methylcitric, Methylcitric (Males Age 13 and Over), Methylcitric (Males Under Age 13), Methylmalonic, Methylmalonic (Males Age 13 and Over), Methylmalonic (Males Under Age 13), Methylsuccinic, Methylsuccinic (Males Age 13 and Over), Methylsuccinic (Males Under Age 13), N-Acetylaspartic, N-Acetylaspartic (Males Age 13 and Over), N-Acetylaspartic (Males Under Age 13), N-Acetylcysteine (NAC), N-Acetylcysteine (NAC) (Males Age 13 and Over), N-Acetylcysteine (NAC) (Males Under Age 13), Orotic, Orotic (Females Under Age 13), Orotic (Males Age 13 and Over), Orotic (Males Under Age 13), Oxalic, Oxalic (Females Under Age 13), Oxalic (Males Age 13 and Over), Oxalic (Males Under Age 13), Pantothenic (B5), Pantothenic (B5) (Males Age 13 and Over), Pantothenic (B5) (Males Under Age 13), Phenyllactic, Phenyllactic (Males Age 13 and Over), Phenyllactic (Males Under Age 13), Phenylpyruvic, Phenylpyruvic (Males Age 13 and Over), Phenylpyruvic (Males Under Age 13), Phosphoric, Phosphoric (Males Age 13 and Over), Phosphoric (Males Under Age 13), Pyridoxic (B6), Pyridoxic (B6) (Males Age 13 and Over), Pyridoxic (B6) (Males Under Age 13), Pyroglutamic, Pyroglutamic (Males Age 13 and Over), Pyroglutamic (Males Under Age 13), Pyruvic, Pyruvic (Females Under Age 13), Pyruvic (Males Age 13 and Over), Pyruvic (Males Under Age 13), Quinolinic, Quinolinic (Males Age 13 and Over), Quinolinic (Males Under Age 13), Quinolinic / 5-HIAA Ratio, Sebacic, Sebacic (Males Age 13 and Over), Sebacic (Males Under Age 13), Suberic, Suberic (Males Age 13 and Over), Suberic (Males Under Age 13), Succinic, Succinic (Females Under Age 13), Succinic (Males Age 13 and Over), Succinic (Males Under Age 13), Tartaric, Tartaric (Males Age 13 and Over), Tartaric (Males Under Age 13), Thymine, Thymine (Males Age 13 and Over), Thymine (Males Under Age 13), Tricarballylic, Tricarballylic (Females Under Age 13), Tricarballylic (Males Age 13 and Over), Tricarballylic (Males Under Age 13), Uracil, Uracil (Males Age 13 and Over), Uracil (Males Under Age 13), Vanillylmandelic (VMA), Vanillylmandelic (VMA) (Males Age 13 and Over), Vanillylmandelic (VMA) (Males Under Age 13)
