Optimal Result: 0 - 1.3 mmol/mol creatinine.

A conjugate of the amino acids, glycine and hydroxybenzoic acid (salicylic acid). Intake of aspirin (salicylates) or the growth of salicylate-producing gastrointestinal bacteria may elevate levels. Also increased after the ingestion of the arti cial sweetener, aspartame (Nutrasweet).

What does it mean if your 2-Hydroxyhippuric result is too high?

High 2-hydroxyhippuric acid may result from: 

- ingestion of aspartame (Nutrasweet)

- salicylates (aspirin)

- dietary salicylates

- from GI bacteria converting tyrosine or phenylalanine to salicylic acid. 

Very high 2-hydroxyhippuric also inhibits dopamine beta-hydroxylase resulting in elevated HVA, decreased VMA, and elevated HVA/VMA ratio.

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