T + B-Lymphocyte Differential
Performed by: Labcorp
The "T + B-Lymphocyte Differential" panel by Labcorp is a comprehensive test that involves flow cytometry methodology to evaluate different subsets of lymphocytes in the blood. This test includes the analysis of various lymphocyte types such as T cells (CD3+), B cells (CD19+), and natural killer (NK) cells (CD3^{-}CD56+). It provides detailed measurements like the percentage and absolute counts of these cells, as well as the CD4:CD8 ratio, which is crucial in assessing immune system health.
Specifically, the test measures the percentages and absolute counts of CD3+ T cells, CD3+CD4+ helper/inducer cells, CD3+CD8+ suppressor/cytotoxic cells, CD19+ B cells, and CD3^{-}CD56+ NK cells. Additionally, it includes a complete blood count (CBC) with differential and platelet count. This panel is particularly useful in the classification and diagnosis of primary immunodeficiency diseases and in monitoring patients with AIDS.
The test requires a whole blood specimen, collected in specific types of tubes, and it's important that the specimen is handled correctly to maintain its viability. The expected turnaround time for test results is generally between 1 to 3 days. However, additional time may be needed for confirmatory or reflex tests.
The "T + B-Lymphocyte Differential" panel is significant for its role in understanding various conditions affecting the immune system, including evaluating and monitoring HIV infection. In HIV-1 infected patients, for instance, the test can provide valuable information about the progression of the disease and the effectiveness of antiretroviral therapy, as it typically shows a decrease in CD4 T cells and an increase in CD8 T cells, along with a decrease in the CD4:CD8 ratio.
This comprehensive approach to lymphocyte profiling is essential in contemporary clinical immunology, providing clinicians with detailed insights into the status and functioning of a patient's immune system.
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Biomarkers included in this panel:
% CD 3 Pos. Lymph.
The biomarker "% CD 3 Pos. Lymph." in a T + B-Lymphocyte Differential panel from Labcorp refers to the percentage of lymphocytes in the blood that are CD3 positive. CD3 is a protein complex and a T-cell co-receptor that defines T-lymphocyte
Learn more% CD 4 Pos. Lymph.
The CD4 percentage (CD4%) is the percentage of white blood cells (lymphocytes) that are CD4 cells. The immune system contains lots of different cells. The two main types of lymphocytes are T cells and B cells. CD4 cells are a type of T cell. So th
Learn more% CD 8 Pos. Lymph.
The proportion of all T cells that are CD8 cells. CD8 cells are also called cytotoxic T-lymphocytes. They help fight cancer and germs that live inside your cells (intracellular pathogens). The CD8 percentage is sometimes more reliable than the
Learn more% CD19+ Lymphs
The biomarker "% CD19+ Lymphs" in a T + B-Lymphocyte Differential panel from Labcorp quantifies the percentage of lymphocytes in the blood that are B cells, identified by the presence of the CD19 protein on their surface. CD19 is a critical
Learn moreAbs. CD 8 Suppressor
The "Abs. CD 8 Suppressor" biomarker in a T + B-Lymphocyte Differential panel from Labcorp measures the absolute count of CD8 positive suppressor T-cells in the blood. CD8 cells, also known as cytotoxic T cells, play a critical role in the
Learn moreAbs.CD19+ Lymphs
The biomarker "Abs.CD19+ Lymphs" in the T + B-Lymphocyte Differential panel from Labcorp measures the absolute count of CD19 positive lymphocytes, which are primarily B cells. CD19 is a marker indicating B cell presence, crucial for the ada
Learn moreAbsolute CD 3
CD3 is a protein complex on the surface of mature T-lymphocytes, and laboratories use it to recognize a T cell. The absolute CD3 count is therefore a headcount: how many T cells are in a microliter of blood. Check the scale before anything else. L
Learn moreAbsolute CD 4 Helper
The CD4 cells are Helper T-cells expressing both CD3 and CD4. CD4 T-cells levels are a criterion for categorizing HIV-related clinical conditions by CDC's classification system for HIV infection. The measurement of CD4 T-cell levels has been u
Learn moreCD4/CD8 Ratio
This test looks at the ratio of two important types of white blood cells in your blood. Lymphocytes are a type of white blood cell in your immune system. This test looks at two of them, CD4 and CD8. CD4 cells lead the fight against infecti
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