% CD 3 Pos. Lymph.
Blood
The proportion of all immune cells that are T cells
T + B-Lymphocyte Differential
The "T + B-Lymphocyte Differential" panel by Labcorp is a comprehensive test that involves flow cytometry methodology to evaluate different subsets of lymphocytes in the blood. This test includes the analysis of various lymphocyte types such as T cells (CD3+), B cells (CD19+), and natural killer (NK) cells (CD3^{-}CD56+). It provides detailed measurements like the percentage and absolute counts of these cells, as well as the CD4:CD8 ratio, which is crucial in assessing immune system health.
Specifically, the test measures the percentages and absolute counts of CD3+ T cells, CD3+CD4+ helper/inducer cells, CD3+CD8+ suppressor/cytotoxic cells, CD19+ B cells, and CD3^{-}CD56+ NK cells. Additionally, it includes a complete blood count (CBC) with differential and platelet count. This panel is particularly useful in the classification and diagnosis of primary immunodeficiency diseases and in monitoring patients with AIDS.
The test requires a whole blood specimen, collected in specific types of tubes, and it's important that the specimen is handled correctly to maintain its viability. The expected turnaround time for test results is generally between 1 to 3 days. However, additional time may be needed for confirmatory or reflex tests.
The "T + B-Lymphocyte Differential" panel is significant for its role in understanding various conditions affecting the immune system, including evaluating and monitoring HIV infection. In HIV-1 infected patients, for instance, the test can provide valuable information about the progression of the disease and the effectiveness of antiretroviral therapy, as it typically shows a decrease in CD4 T cells and an increase in CD8 T cells, along with a decrease in the CD4:CD8 ratio.
This comprehensive approach to lymphocyte profiling is essential in contemporary clinical immunology, providing clinicians with detailed insights into the status and functioning of a patient's immune system.
Biomarkers in this category
9 biomarkers · optimal ranges shown
% CD 4 Pos. Lymph.
Blood
the percentage of white blood cells (lymphocytes) that are CD4 cells.
% CD 8 Pos. Lymph.
Blood
The proportion of all T cells that are CD8 cells.
% CD19+ Lymphs
Blood
percentage of lymphocytes in the blood that are B cells
Abs. CD 8 Suppressor
Blood
measures the absolute count of CD8 positive suppressor T-cells
Abs.CD19+ Lymphs
Blood
The biomarker "Abs.CD19+ Lymphs" in the T + B-Lymphocyte Differential panel from Labcorp measures the absolute count of CD19 positive lymphocytes, which are primarily B cells. CD19 is a marker indicating B cell presence, crucial for the adaptive immune response, especially in antibody production. This absolute count provides a specific numerical value rather than a percentage, offering a direct measure of the B cell population in the blood. It's instrumental in diagnosing and monitoring conditions affecting B cell function, such as immunodeficiency disorders, certain types of leukemia, and autoimmune diseases. Understanding variations in these counts is vital for evaluating the immune system's health and function.
Absolute CD 3
Blood
The absolute CD3 count — your total T-lymphocyte count.
Absolute CD 4 Helper
Blood
The CD4 cells are Helper T-cells expressing both CD3 and CD4.
CD4/CD8 Ratio
Blood
CD4 cells lead the fight against infections. CD8 cells can kill cancer cells and other invaders.