A component of the dietary peptide anserine.
OMX Organic Metabolomics / Diagnostic Solutions
OMX™ Organic Metabolomics Test – Diagnostic Solutions Laboratory
The OMX™ Organic Metabolomics Test is an advanced functional health assessment that analyzes organic acids, amino acids, and other key metabolites to provide a detailed view of your body’s metabolic function and nutrient needs. Developed by Diagnostic Solutions Laboratory, this test offers insights into how well your body processes food, generates energy, detoxifies, and responds to environmental stressors.
What Does the OMX™ Test Measure?
The OMX™ test evaluates biomarkers related to:
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Metabolic pathway efficiency
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Mitochondrial energy production
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Amino acid balance and utilization
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Nutrient and vitamin cofactor levels
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Detoxification and oxidative stress
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Gut microbial metabolites and dysbiosis
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Mood and neurotransmitter metabolism
Who Should Consider the OMX™ Test?
This test is ideal for individuals experiencing:
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Chronic fatigue or low energy
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Nutrient deficiencies despite supplementation
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Cognitive or mood changes
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Digestive issues or bloating
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Hormonal or metabolic imbalances
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Suspected exposure to toxins or oxidative stress
Key Benefits of the OMX™ Organic Acids and Amino Acids Profile:
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Comprehensive metabolic health overview
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Early detection of functional imbalances
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Supports personalized nutrition and treatment plans
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Useful in chronic conditions, functional medicine, and integrative care
Sample Type:
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Urine or plasma (easy sample collection options available)
Gain a deeper understanding of your body's unique biochemistry and take the guesswork out of nutrition, detox, and lifestyle decisions with the OMX™ Organic Metabolomics Test.
Biomarkers in this category
162 biomarkers · optimal ranges shown
Dietary Peptide Related Markers
Xylene exposure
a normal metabolite found in human fluids
An amino acid which is excreted in human urine.
an acyl glycine
found in red beetroot, common beet, olives, and correlated with coffee intake
highly correlated with intake of whole-grain bread and breakfast cereals
One of the most abundant phenolates formed by the microbiota
A tyrosine metabolic product of GI bacteria.
AKA: 4-Hydroxyphenylpyruvate, 4-HPPA
Metabolite of serotonin
measures the oxidative impact to DNA
Aminotransferase + B6
relates to oxidative stress
B-Complex Vitamin Marker
Lactate dehydrogenase + B3
important for proper metabolism of all essential amino acids
B-Complex Vitamin Marker
A B complex vitamin marker
Fatty acid metabolite
Alanine transaminase + B6
a potential predictor of insulin resistance and diabetes
Steroid 5-beta reductase
Anserinase
Part of a group of Beta-Amino Acids and Derivatives.
From the breakdown of kynurenine via kynureninase (KYNU) +B6, a side pathway
a marker for invasive candidiasis or infection by Candida fungal species
Arginase & Nitric oxide synthase
It is not normally detectable in healthy adults. Adult argininosuccinate lyase insufficiencies are typically treated with a lower protein/higher carbohydrate diet, arginine supplementation, and avoidance of fasting.
Nonessential Protein Amino Acid
Amino acid metabolism marker
Nonessential Protein Amino Acids
Combines with histidine to form carnosine.
Combines with histidine to form carnosine
b-hydroxybutyrate is one of the ketone bodies.
Biotin Markers
Benzoate
Styrene exposure
B-Vitamin Complex (B1, B2, B3, B5, LA)
Carnosine is generally very low and increases proportionally after meat intake. Urine levels peak after ~5 hours and are completely excreted within 20–25 hours. Urine carnosine increased with albuminuria in patients with diabetes. People with eGFR < 30 ml/mi had higher urine-carnosine excretion rates compared to eGFR (> 90 ml).
Dietary Peptide Related Markers
Involved in both energy production and removal of toxic ammonia.
Citrate synthase
Argininosuccinate synthase
Stress Hormone
11beta-hydroxysteroid dehydrogenase + B3
Creatine breakdown
B-Vitamin Markers
Oxidation
Oxidation
D-Lactate is produced by bacteria residing in the colon.
a bacterial-derived metabolite with estrogenic and antioxidant activity
Glycine/Serine Metabolites
Ethanolamine kinase
Metabolite of the omega fatty acid pathway.
Methylation Markers (Folate, B12)
Emerging research seems to show a relationship between the rise in metabolic diseases and the increased consumption of fructose—particularly consumption of non-natural sources of fructose found in sugar-sweetened beverages and other processed foods. Elevated fructose levels should be further investigated. Dietary fructose intake should be determined, modified if excessive, and monitored for metabolic changes.
Used in the body’s metabolic pathway that generates cellular energy.
gamma-Aminobutyric acid aminotransferase + B6
Nonessential Protein Amino Acids
Glucarate / D-Glucaric Acid
Glucokinase
Nonessential Protein Amino Acids
Glutamic acid (glutamate) supports energy, brain, and detox pathways. Abnormal levels may signal stress, poor protein intake, or metabolic imbalance.
A precursor to glutamate and GABA
- Glutamic acid has been associated with higher BMI, blood pressure, and insulin resistance, while glutamine levels were inversely associated. - A high plasma glutamine-to-glutamic acid ratio was associated with lower risk of diabetes in the Framingham Heart Study (n=1015). - Higher glutamine-to-glutamic acid ratio was associated with a better cardiometabolic-risk profile over 10 years in the PRIMED study (n=1879).
Glutaminase
A breakdown product of lysine and/or tryptophan
Glycine/Serine Metabolites
Glutathione synthetase
Dipeptide of Glycine + Proline
Collagen Catabolism
Glutamate/ [Serine + Glycine] GSG Index
a specific marker for the diagnosis of Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency.
Hippurate
Histidine decarboxylase + B6
Histidine decarboxylase + B6
Homocitrulline is a marker that may indicate how much protein carbamoylation is happening in the body. Protein carbamoylation is a process where isocyanate reacts with the amino acid lysine, resulting in the formation of homocitrulline. This modification is thought to contribute to molecular aging and is linked to various health issues, including atherosclerosis (a condition where arteries become narrowed) and problems with the immune system. Research has shown that patients with chronic kidney disease tend to have higher levels of homocitrulline, and these levels are positively related to urea concentration, which is a waste product that builds up when the kidneys are not functioning properly. Additionally, individuals with coronary artery disease also exhibit significantly elevated serum homocitrulline levels. This suggests that measuring homocitrulline can provide valuable insights into certain health conditions and the overall metabolic state of a person.
→ Plasma homocystine is higher in those with cystathionine-beta-synthase deficiency. → Plasma homocystine, as well as taurine, were significantly lower in insufficient methotrexate therapy responders. → Homocystine is an oxidized disulfide form of homocysteine, which gets readily converted to cystathionine.
A common amino acid in your blood
A breakdown product of 4-Hydroxyphenylpyruvic Acid (4-HPPA)
a metabolite of dopamine
a metabolic intermediate of the kynurenine pathway
Hydroxyproline is the key factor in stabilizing collagens
Collagen Catabolism
Learn what Indoleacetic Acid (IAA) means on your lab test. This gut-derived metabolite reflects bacterial tryptophan fermentation. Discover how high or low IAA levels relate to gut health, digestion, liver function, and microbial balance.
Citric acid, cis-aconitic acid, and isocitric acid are the first three metabolites in the Krebs cycle.
Branched Chain Amino Acid
Kynurenine/Tryptophan Ratio (KTR)
Kynurenine/Tryptophan Ratio (KTR)
Other names: Kynurenate A breakdown product from kynurenine via kynurenine aminotransferases (KAT) Kynurenic Acid is product of the metabolism of L-Tryptophan and appears in urine in Vitamin B6 deficiencies. Your body needs vitamin B6 (pyridoxine) to utilize amino acids derived from dietary protein. Inadequate vitamin B6 is one factor that leads to increased concentrations of kynurenate and xanthurenate in urine. These products of amino acid breakdown cannot be further metabolized in the absence of vitamin B6. - Elevated kynurenine, kynurenic acid, xanthurenic acid, quinolinic acid, and a high KYN/TRP ratio seen in metabolic syndrome. - In animal studies exercise-induced conversion to kynurenic acid was seen. - Alcoholic B3-deficient patients had increased kynurenic acid, and decreased xanthurenic acid and quinolinic acid. - Urine levels of citric acid, hippuric acid, p-cresol, 2-aminobutyrate, putrescine, and kynurenic acid, were able to discriminate colorectal cancer patients from healthy controls. Kynurenic acid was lower in patients. - In a mathematical model without a tryptophan load, a moderate B6 deficiency resulted in slight decreases in kynurenic.
The primary breakdown product of tryptophan
The primary breakdown product of tryptophan
Lactate dehydrogenase + B3
Branched Chain Amino Acids
Lysine catabolism leads to collagen and carnitine production
Marker for mitochondrial dysfunction
→ Mandelic acid and benzoylformate are major metabolites of styrene and ethylbenzene exposure. → Styrene is a key component in consumer products. Occupational exposure has been associated with increased rates of pulmonary, neurological, genetic, ocular, and reproductive complications, plus leukemia. → Styrene can be found in polystyrene packaging and can migrate into packaged food. → Benzoylformate has been associated with metabolism of adrenaline and noradrenaline, and phenylketonuria. → In a review of 2005–2006 and 2011–2012 NHANES data (N=4690), smokers had 2-fold and 1.6-fold higher levels of both markers. → Eating more vegetables and fruit was associated with decreased levels.
Involved in methylation; metabolism leads to glutathione production
Methylation Markers (Folate, B12)
not normally found in urine
Ornithine transcarbamylase
Associated nutrients: Arginine, Magnesium
the most acidic organic acid in body fluids
Learn what your pH level means on the OMX Organic Metabolomics Panel by Diagnostic Solutions Laboratory. Understand how urinary pH reflects acid-base balance, metabolism, gut health, and kidney function.
A bacterial dysbiosis marker
Amino Acid
Phenylalanine metabolism produces catecholamines, thyroid hormones, melatonin.
Glycine/Serine Metabolites
Phosphoethanolamine cytidylyltransferase
Produced under inflammatory conditions
a bona fide precursor of biotin in B. subtilis.
Prolyl hydroxylase + Vitamin C
Nonessential Protein Amino Acids
Vitamin B-6
Toxin & Detoxification Markers
Pyruvate dehydrogenase + B1, B2, B3, B5 LA
Plant Component
Kynurenine Markers (Vitamin B6)
If high it may indicate functional B2 deficiency.
Fatty acid oxidation + Carnitine
involved in cysteine and methionine metabolism
Fatty Acid Metabolism
an acyl glycine
An important metabolite that is involved in several chemical processes in the body.
Sulfocysteine is the product of sulfite-dependent cleavage of cystine. In the pathway, cysteine becomes sulfite, which converts to sulfate via sulfite oxidase + Mo. If the pathway is blocked, sulfocysteine builds up.
Sulfite oxidase (SOX) + Mo
Plant Components
Hypotaurine dehydrogenase
Glycine C-acetyltransferase + B6
key nitrogen donors
Tryptophan-2,3-dioxygenase/Indoleamine-2,3-dioxygenase
Least abundant amino acid
Produced from phenylalanine via phenylalanine hydroxylase + BH4
Produced from phenylalanine via phenylalanine hydroxylase + BH4
a branched-chain amino acid (BCAA)
Metabolite of epinephrine and norepinephrine.
From the breakdown of hydroxykynurenine