Cytokine Response Profile (CytoDx), Diagnostic Solutions
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Performed by: Diagnostic Solutions Laboratory | GI-MAP & Food Sensitivity Tests
Cytokine Response Profile (CytoDx) – Diagnostic Solutions Laboratory
The Cytokine Response Profile (CytoDx) by Diagnostic Solutions Laboratory provides a detailed look at how your immune system regulates inflammation and communication between immune cells. This advanced cytokine panel test measures key signaling molecules—called cytokines—that coordinate immune activity and influence how your body responds to infection, stress, and chronic illness.
When cytokine levels become imbalanced, they can contribute to chronic inflammation, autoimmune reactions, or weakened immune defense. The CytoDx test helps identify these immune patterns, offering clinicians insight into your body’s inflammatory status and immune regulation at the cellular level.
How the Test Works
This test analyzes cytokines related to major immune pathways—Th1, Th2, Th17, and Treg cells. Each pathway plays a distinct role in immune defense, inflammation control, and recovery.
Pro-Inflammatory Cytokines
These markers promote immune activation and inflammation in response to infection or tissue damage:
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GM-CSF (Granulocyte-Macrophage Colony-Stimulating Factor): stimulates immune cell production
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IFN-γ (Interferon Gamma, Th1): activates macrophages and supports cellular immunity
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IL-1β, IL-2, IL-6, IL-7, IL-8, IL-12p70, IL-15, IL-17A (Th17), IL-18, TNF-α: key mediators of inflammatory and autoimmune processes
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MIP-1β (CCL4) and RANTES (CCL5): recruit immune cells to inflamed areas
Elevated levels of these cytokines can indicate autoimmune disease, chronic infection, metabolic inflammation, or neuroimmune dysregulation.
Anti-Inflammatory Cytokines
These markers help calm the immune system and promote recovery:
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IL-4, IL-5, IL-13 (Th2): support antibody production and help reduce inflammation
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IL-10 (Treg): suppresses excessive immune activity to maintain proper regulation
Low anti-inflammatory cytokine activity may contribute to unresolved inflammation, allergic reactivity, or autoimmune flare-ups.
Clinical Meaning and Immune Patterns
By mapping cytokine levels across immune pathways, the Cytokine Response Profile can reveal characteristic immune imbalances, including:
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Th1 dominance: associated with autoimmune or intracellular infection responses
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Th2 dominance: linked to allergies, asthma, and atopic conditions
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Th17 activation: connected to chronic inflammatory and autoimmune states
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Low Treg (IL-10): indicates reduced immune tolerance and regulation
Identifying these immune signatures allows healthcare practitioners to create personalized treatment strategies that rebalance immune activity, reduce inflammation, and enhance long-term immune resilience.
Who the CytoDx Test Is For
The CytoDx panel is valuable for individuals with:
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Chronic fatigue, inflammation, or immune-related symptoms
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Autoimmune or allergic conditions
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Persistent or recurrent infections
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Signs of immune dysregulation or unexplained inflammation
Summary
The Cytokine Response Profile (CytoDx) from Diagnostic Solutions Laboratory offers a comprehensive assessment of immune signaling and cytokine balance. By pinpointing cytokine imbalances across Th1, Th2, Th17, and Treg pathways, clinicians can uncover hidden inflammatory drivers and design targeted interventions to restore immune balance, resilience, and optimal health.
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Biomarkers included in this panel:
GM-CSF stands for Granulocyte-Macrophage Colony-Stimulating Factor. It is one of the cytokines evaluated in the CytoDx Cytokine Response Profile test offered by Diagnostic Solutions Laboratory. Cytokines are critical mediators of immune resp
Learn moreIFN gamma refers to Interferon-gamma. Interferon-gamma is one of the cytokines assessed in the CytoDx Cytokine Response Profile offered by Diagnostic Solutions Laboratory. Cytokines are important mediators of immune responses, and their imbalances ha
Learn moreIL-1 beta refers to Interleukin-1 beta. Interleukin-1 beta is one of the cytokines assessed in the CytoDx Cytokine Response Profile offered by Diagnostic Solutions Laboratory. Cytokines are critical mediators of immune responses, and their imbalances
Learn moreIL-10 (Interleukin-10) is a powerful anti-inflammatory cytokine that helps control immune overactivation and maintain immune tolerance. Produced by regulatory T cells (Tregs), monocytes, and macrophages, IL-10 suppresses excessive inflammatory signal
Learn moreIL-13 (Interleukin-13) is an anti-inflammatory Th2 cytokine that regulates antibody production, tissue repair, and mucosal immunity. Produced by Th2 cells, mast cells, and ILC2s, IL-13 helps resolve inflammation but can also drive allergic and fibrot
Learn moreIL-15 (Interleukin-15) is a pro-inflammatory cytokine that activates natural killer (NK) cells and CD8+ T cells, strengthening the body’s defense against infections and tumors. It also promotes interferon-gamma (IFN-γ) production, amplify
Learn moreIL-17A (Interleukin-17A) is a pro-inflammatory cytokine produced by Th17 cells that plays a key role in defending against bacterial and fungal infections. It promotes neutrophil recruitment and stimulates other inflammatory cytokines like IL-6 and TN
Learn moreIL-18 (Interleukin-18) is a pro-inflammatory cytokine that activates Th1 and natural killer (NK) cells, driving the release of interferon-gamma (IFN-γ) and amplifying immune and inflammatory responses. While essential for fighting infections, p
Learn moreIL-2 (Interleukin-2) is a pro-inflammatory Th1 cytokine that promotes the growth and activation of T cells, NK cells, and B cells, playing a key role in immune defense and regulation. Produced by activated T-helper cells, IL-2 strengthens immune resp
Learn moreIL-4 (Interleukin-4) is an anti-inflammatory cytokine that promotes Th2 immune activity and supports antibody production, immune tolerance, and tissue repair. Produced by Th2 cells, mast cells, and basophils, IL-4 helps suppress excessive Th1-driven
Learn moreIL-5 (Interleukin-5) is an anti-inflammatory Th2 cytokine that stimulates the production and activation of eosinophils, immune cells involved in allergic reactions, asthma, and defense against parasites. Produced by Th2 cells, mast cells, and ILC2s,
Learn moreIL-6 (Interleukin-6) is a pro-inflammatory cytokine that plays a central role in inflammation, immune defense, and metabolic regulation. Produced by immune and tissue cells, IL-6 triggers the liver’s acute-phase response, supports antibody prod
Learn moreIL-7 (Interleukin-7) is a cytokine essential for the development, maintenance, and survival of T and B lymphocytes, key players in the body’s adaptive immune system. Produced by stromal and epithelial cells in the bone marrow and thymus, IL-7 h
Learn moreIL-8 (Interleukin-8) is a pro-inflammatory chemokine that recruits neutrophils and other immune cells to sites of infection or tissue injury. Produced by immune and epithelial cells, IL-8 helps the body mount an effective inflammatory response, but w
Learn moreMIP-1β (Macrophage Inflammatory Protein-1 beta, CCL4) is a pro-inflammatory chemokine that helps guide immune cells—including monocytes, NK cells, and T lymphocytes—to areas of infection or injury. Produced by macrophages and T cells
Learn moreT-Cell-Specific Protein RANTES is chemotactic for T-cells, human eosinophils and basophils and plays an active role in recruiting leukocytes into inflammatory sites. It also activates the release of proteins from eosinophils such as eosinophilic cati
Learn moreTNF-alpha is an important protein in your immune system that plays a big role in inflammation and overall health. It's part of a CYTOKINES Panel and helps your body respond to injuries, infections, and other issues. TNF-alpha is made by i
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