Performed by: Doctor's Data

Celiac disease is a common but often underdiagnosed autoimmune condition that affects the small intestine and impairs nutrient absorption. Over time, untreated celiac disease can contribute to a wide range of health issues, including digestive symptoms, nutrient deficiencies, fatigue, and even other autoimmune disorders. Many individuals remain asymptomatic for years, making early detection especially important.

This panel evaluates key antibodies associated with both celiac disease and non-celiac gluten sensitivity (NCGS). These markers reflect how the immune system responds to gluten exposure. For accurate results, it is essential that testing is performed while consuming a gluten-containing diet.

The primary antibodies measured include:

Tissue Transglutaminase (tTG) antibodies
Deamidated Gliadin Peptide (DGP) antibodies

Testing includes both IgA and IgG antibodies. While IgA is typically used for celiac screening, individuals with celiac disease have a higher likelihood of selective IgA deficiency, which can lead to false-negative results if IgG markers are not assessed. Including both antibody types improves diagnostic accuracy.

What a Positive Result May Indicate

Elevated antibody levels may suggest:

Celiac disease
Non-celiac gluten sensitivity
Ongoing immune activation in response to gluten

If results are positive, further clinical evaluation and confirmatory testing may be recommended.

What to Do If You’re Diagnosed

If celiac disease is confirmed, the cornerstone of treatment is a strict, lifelong gluten-free diet. This involves eliminating:

Wheat
Barley
Rye
Foods containing hidden sources of gluten

Even small amounts of gluten can trigger inflammation and intestinal damage, so careful dietary management is critical for long-term health.

Why This Test Matters

Early detection of gluten-related disorders can help prevent:

Chronic digestive issues
Malabsorption and nutrient deficiencies
Long-term complications, including autoimmune conditions

Additional Testing

For a more comprehensive view of gut health, advanced testing such as a full stool analysis may provide additional insight into digestion, absorption, and microbiome balance.

Biomarkers included in this panel:

Deamidated Gliadin Peptide (DGP) IgA

Blood Spot

Deamidated Gliadin Peptide (DGP) IgA is an antibody that reflects the immune system’s response to gluten. It is commonly used in the evaluation of celiac disease and may help identify gluten-related immune activation, particularly in early or a

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Deamidated Gliadin Peptide (DGP) IgG

Blood Spot

Deamidated Gliadin Peptide (DGP) IgG is an antibody that reflects the immune system’s response to gluten. It is particularly useful in identifying celiac disease in individuals with IgA deficiency or when other celiac markers are inconclusive.

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Gliadin (AGA) IgA

Blood Spot

Gliadin (AGA) IgA is an antibody that reflects the immune system’s response to gliadin, a component of gluten. Elevated levels may indicate gluten sensitivity or immune activation related to celiac disease, although this marker is less specific

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Gliadin (AGA) IgG

Blood Spot

Gliadin (AGA) IgG is an antibody that reflects the immune system’s response to gliadin, a component of gluten. Elevated levels may indicate gluten sensitivity or immune activation, particularly in individuals with IgA deficiency or non-celiac g

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Celiac & Gluten Sensitivity; blood spot

Performed by: Doctor's Data

What a Positive Result May Indicate

What to Do If You’re Diagnosed

Why This Test Matters

Additional Testing

Biomarkers included in this panel:

Deamidated Gliadin Peptide (DGP) IgA

Deamidated Gliadin Peptide (DGP) IgG

Gliadin (AGA) IgA

Gliadin (AGA) IgG

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