5b-Pregnanediol (Post-menopausal)

Optimal Result: 70 - 320 ng/mg Creat/Day.

5B-PD is the major progesterone metabolite.

Progesterone is produced by the corpus luteum following ovulation and to a lesser extent by the adrenal glands in both sexes. While found in the urine in small amounts, progesterone can be seen as a clinical marker of luteul activity and theraputic oral progesterone administration.

The most important progesterone metabolite, pregnanediol (PDL), can serve as a urinary marker for endogenous progesterone levels and as an indicator of ovulation. PDL exists as two isomers, 5α-pregnanediol and 5β-pregnanediol. 5β-pregnanediol represents the majority end point of endogenous progesterone metabolism and appears to have little activity within the body, while 5α-pregnanediol, the lesser metabolite of PDL, can cross the blood brain barrier and may partially agonize GABA-A receptors.

This action is possibly due to its role as an immediate precursor to allopregnanolone. Allopregnanolone is a potent neuroactive steroid capable of binding the GABA-A receptor often leading to sedative and anxiolytic action. The calming action of allopregnanolone is often seen with orally supplemented progesterone, as the liver metabolizes a large portion of oral progesterone to the neuroactive steroid allopregnanolone.

What does it mean if your 5b-Pregnanediol (Post-menopausal) result is too low?

Lower levels of pregnanediol are seen in cases of amenorrhea, decreased ovarian function, PCOS, ovarian cancer, and certain complications of pregnancy.

What does it mean if your 5b-Pregnanediol (Post-menopausal) result is too high?

5B-PD is the major progesterone metabolite. Increased levels may be due to high levels of progesterone and/or pregnenolone, pregnancy, ovarian cyst, pregnenolone and/or progesterone supplementation, or adrenocorticohyperplasia. In addition, elevations of both progesterone and pregnanediol have been reported in 21-hydroxylase deficiency.

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