Methyl metabolites are considered inactive and are correlated with antiproliferative effects. Proper elimination of 4-M-E2 requires optimal excretion via GI tract optimization. To fully understand this value, it may be beneficial to examine the 4-M-E2 / 4-OH-E2 ratio.
Lower levels of 4-M-E2 is associated with a higher risk of certain cancers and other negative markers for breast health in females. Due to lack of research in this area, it can be postulated that males carry a similar risk. Low levels of 4-M-E2 may indicate that 4-OH metabolites are favoring the quinone/ semi quinone pathway which can lead to DNA damage. Supporting the COMT enzyme (methylation) is a
consideration.
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Methyl metabolites are considered inactive and are correlated with antiproliferative effects. Proper elimination of 4-M-E2 requires optimal excretion via GI tract optimization. To fully understand this value, it may be beneficial to examine the 4-M-E2 / 4-OH-E2 ratio.
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