Methyl metabolites are considered inactive and are correlated with antiproliferative effects. Proper elimination of 4-M-E2 requires optimal excretion via GI tract optimization. To fully understand this value, it may be beneficial to examine the 4-M-E2 / 4-OH-E2 ratio.
Lower levels of 4-M-E2 is associated with a higher risk of certain cancers and other negative markers for breast health in females. Due to lack of research in this area, it can be postulated that males carry a similar risk. Low levels of 4-M-E2 may indicate that 4-OH metabolites are favoring the quinone/ semi quinone pathway which can lead to DNA damage. Supporting the COMT enzyme (methylation) is a
consideration.
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Methyl metabolites are considered inactive and are correlated with antiproliferative effects. Proper elimination of 4-M-E2 requires optimal excretion via GI tract optimization. To fully understand this value, it may be beneficial to examine the 4-M-E2 / 4-OH-E2 ratio.
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1-hydroxy-Etiocholanolone (Post-menopausal), 11-Deoxycortisol (male), 11-Deoxycortisol (Post-menopausal), 11-Deoxycortisol (Pre-menopausal), 11-hydroxy-Androsterone (male), 11-hydroxy-Androsterone (Post-menopausal), 11-hydroxy-Androsterone (Pre-menopausal), 11-hydroxy-Etiocholanolone (male), 11-hydroxy-Etiocholanolone (Post-menopausal), 11-hydroxy-Etiocholanolone (Pre-menopausal), 16-OH-E1 % (male), 16-OH-E1 % (Post-menopausal), 16-OH-E1 % (Pre-menopausal), 16a-Hydroxyestrone (male), 16a-Hydroxyestrone (Post-menopausal), 16a-Hydroxyestrone (Pre-menopausal), 17-Hydroxyprogesterone (male), 17-Hydroxyprogesterone (Post-menopausal), 17-Hydroxyprogesterone (Pre-menopausal), 2-Hydroxyestradiol (male), 2-Hydroxyestradiol (Post-menopausal), 2-Hydroxyestradiol (Pre-menopausal), 2-Hydroxyestrone (male), 2-Hydroxyestrone (Post-menopausal), 2-Hydroxyestrone (Pre-menopausal), 2-M-E1:2-OH-E1 (male), 2-M-E1:2-OH-E1 (Post-menopausal), 2-M-E1:2-OH-E1 (Pre-menopausal), 2-M-E2:2-OH-E2 (male), 2-M-E2:2-OH-E2 (Post-menopausal), 2-M-E2:2-OH-E2 (Pre-menopausal), 2-Methoxyestradiol (male), 2-Methoxyestradiol (Post-menopausal), 2-Methoxyestradiol (Pre-menopausal), 2-Methoxyestrone (male), 2-Methoxyestrone (Post-menopausal), 2-Methoxyestrone (Pre-menopausal), 2-OH-E1 % (male), 2-OH-E1 % (Post-menopausal), 2-OH-E1 % (Pre-menopausal), 2-OH-E1:16-OH-E1 (male), 2-OH-E1:16-OH-E1 (Post-menopausal), 2-OH-E1:16-OH-E1 (Pre-menopausal), 21-Hydroxyprogesterone (male), 21-Hydroxyprogesterone (Post-menopausal), 21-Hydroxyprogesterone (Pre-menopausal), 4-Hydroxyestradiol (male), 4-Hydroxyestradiol (Post-menopausal), 4-Hydroxyestradiol (Pre-menopausal), 4-Hydroxyestrone (male), 4-Hydroxyestrone (Post-menopausal), 4-Hydroxyestrone (Pre-menopausal), 4-M-E1:4-OH-E1 (male), 4-M-E1:4-OH-E1 (Post-menopausal), 4-M-E1:4-OH-E1 (Pre-menopausal), 4-M-E2:4-OH-E2 (male), 4-M-E2:4-OH-E2 (Post-menopausal), 4-M-E2:4-OH-E2 (Pre-menopausal), 4-Methoxyestradiol (male), 4-Methoxyestradiol (Post-menopausal), 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/ Etiocholanolone (5b) (Pre-menopausal), Androsterone (male), Androsterone (Post-menopausal), Androsterone (Pre-menopausal), Corticosterone, Corticosterone (Pre-menopausal), Cortisol Bedtime, Cortisol Bedtime (Pre-menopausal), Cortisol Dinnertime, Cortisol Dinnertime (Pre-menopausal), Cortisol Waking, Cortisol Waking (Pre-menopausal), Cortisol Waking+2hrs, Cortisol Waking+2hrs (Pre-menopausal), Cortisol/Cortisone, Cortisol/Cortisone (Pre-menopausal), Cortisol/day, Cortisol/day (Pre-menopausal), Cortisone Bedtime, Cortisone Bedtime (Pre-menopausal), Cortisone Dinnertime, Cortisone Dinnertime (Pre-menopausal), Cortisone Waking, Cortisone Waking (Pre-menopausal), Cortisone Waking+2hrs, Cortisone Waking+2hrs (Pre-menopausal), Cortisone/day, Cortisone/day (Pre-menopausal), Creatinine Bedtime (male), Creatinine Bedtime (Post-menopausal), Creatinine Bedtime (Pre-menopausal), Creatinine Dinnertime (male), Creatinine Dinnertime (Post-menopausal), Creatinine Dinnertime (Pre-menopausal), 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