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Home › Research › Hormone & Urinary Metabolites Assessment Profile: 4-Methoxyestradiol (male)
Hormone & Urinary Metabolites Assessment Profile

4-Methoxyestradiol (male)

Optimal result: 0.013 – 0.034 ng/mg Creat/Day
Doctor's Data
By Healthmatters Editorial Team
Peer-reviewed sources

Methyl metabolites are considered inactive and are correlated with antiproliferative effects. Proper elimination of 4-M-E2 requires optimal excretion via GI tract optimization. To fully understand this value, it may be beneficial to examine the 4-M-E2 / 4-OH-E2 ratio.

Lower levels of 4-M-E2 is associated with a higher risk of certain cancers and other negative markers for breast health in females. Due to lack of research in this area, it can be postulated that males carry a similar risk. Low levels of 4-M-E2 may indicate that 4-OH metabolites are favoring the quinone/ semi quinone pathway which can lead to DNA damage. Supporting the COMT enzyme (methylation) is a
consideration.

Methyl metabolites are considered inactive and are correlated with antiproliferative effects. Proper elimination of 4-M-E2 requires optimal excretion via GI tract optimization. To fully understand this value, it may be beneficial to examine the 4-M-E2 / 4-OH-E2 ratio.

Methyl metabolites are considered inactive and are correlated with antiproliferative effects. Proper elimination of 4-M-E2 requires optimal excretion via GI tract optimization. To fully understand this value, it may be beneficial to examine the 4-M-E2 / 4-OH-E2 ratio.

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