Percentages of 2-OH-E1, 4-OH-E1, and 16-OH-E1
When evaluating phase I metabolism, it can be helpful to compare the percentages of 2, 4, and 16 OH-E1 metabolites. Most individuals metabolize the majority of their estrogens down the 2-OH-E1 pathway which is generally considered the “safer pathway”. This is followed by 16-OH-E1 and 4-OH-E1 respectively, both of which are deemed more reactive and potentially genotoxic.
4-OH E1 is associated with a higher risk of certain cancers and other markers for breast health in women. Low levels may be beneficial depending on the other metabolites and methylation further down the pathway.
Understand and improve your laboratory results with our health dashboard.
Upload your lab reports and get your interpretation today.
Our technology helps to understand, combine, track, organize, and act on your medical lab test results.
Higher levels indicate slowed methylation and are associated with a higher risk for breast cancer in women. Elevation may also be due to an overactive CYP1B1 enzyme or sluggish CYP1A1 or CYP34A. Additional support for the COMT enzyme can help with the conversion toward the inactive metabolite, 4-M-E1.
Interpret Your Lab Results
Upload your lab report, and we'll interpret and provide you with recommendations today.
Get StartedMonthly plan
Annual plan
Own it for life
Our exclusive data entry service is a convenient way to get your results into your private dashboard. Simply attach an image or a file of your lab test results, and one of our qualified data entry team members will add the results for you. We support all sorts of files, whether PDFs, JPGs, or Excel. This service is excellent whether you have a lot of reports to upload or are too busy to do the data entry yourself.
We strive to make the data entry process easy for you. Whether by offering dozens of templates to choose from that pre-populate the most popular laboratory panels or by giving you instant feedback on the entered values. Our data entry forms are an easy, fast, and convenient way to enter the reports yourself. There is no limit on how many lab reports you can upload.
$15 /month
billed every month
Most popular
Data entry included
$79 /year
$6.60/month billed annually
Data entry included
$250 /once
own it for life
Are You a Health Professional?
Get started with our professional plan
Welcome to Healthmatters Pro.
Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place. Learn more
Pro Monthly Plus
for health professionals
$75 per month
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.
1-hydroxy-Etiocholanolone (Post-menopausal), 11-Deoxycortisol (male), 11-Deoxycortisol (Post-menopausal), 11-hydroxy-Androsterone (male), 11-hydroxy-Androsterone (Post-menopausal), 11-hydroxy-Etiocholanolone (male), 11-hydroxy-Etiocholanolone (Post-menopausal), 16-OH-E1 % (male), 16-OH-E1 % (Post-menopausal), 16a-Hydroxyestrone (male), 16a-Hydroxyestrone (Post-menopausal), 17-Hydroxyprogesterone (male), 17-Hydroxyprogesterone (Post-menopausal), 2-Hydroxyestradiol (male), 2-Hydroxyestradiol (Post-menopausal), 2-Hydroxyestrone (male), 2-Hydroxyestrone (Post-menopausal), 2-M-E1:2-OH-E1 (male), 2-M-E1:2-OH-E1 (Post-menopausal), 2-M-E2:2-OH-E2 (male), 2-M-E2:2-OH-E2 (Post-menopausal), 2-Methoxyestradiol (male), 2-Methoxyestradiol (Post-menopausal), 2-Methoxyestrone (male), 2-Methoxyestrone (Post-menopausal), 2-OH-E1 % (male), 2-OH-E1 % (Post-menopausal), 2-OH-E1:16-OH-E1 (male), 2-OH-E1:16-OH-E1 (Post-menopausal), 21-Hydroxyprogesterone (male), 21-Hydroxyprogesterone (Post-menopausal), 4-Hydroxyestradiol (male), 4-Hydroxyestradiol (Post-menopausal), 4-Hydroxyestrone (male), 4-Hydroxyestrone (Post-menopausal), 4-M-E1:4-OH-E1 (male), 4-M-E1:4-OH-E1 (Post-menopausal), 4-M-E2:4-OH-E2 (male), 4-M-E2:4-OH-E2 (Post-menopausal), 4-Methoxyestradiol (male), 4-Methoxyestradiol (Post-menopausal), 4-Methoxyestrone (male), 4-Methoxyestrone (Post-menopausal), 4-OH-E1 % (male), 4-OH-E1 % (Post-menopausal), 4-OH-E1:2-OH-E1 (male), 4-OH-E1:2-OH-E1 (Post-menopausal), 5-pregnenetriol (male), 5-pregnenetriol (Post-menopausal), 5a-Androstanediol (male), 5a-Androstanediol (Post-menopausal), 5a-Dihydrotestosterone (male), 5a-Dihydrotestosterone (Post-menopausal), 5A-PD:5B-PD (male), 5A-PD:5B-PD (Post-menopausal), 5a-Pregnanediol (male), 5a-Pregnanediol (Post-menopausal), 5a-Tetrahydrocorticosterone, 5a-Tetrahydrocortisol (male), 5a-Tetrahydrocortisol (Post-menopausal), 5A-THF+5B-THF/THE (male), 5A-THF+5B-THF/THE (Post-menopausal), 5A-THF/5B-THF ratio (male), 5A-THF/5B-THF ratio (Post-menopausal), 5b-Androstanediol (male), 5b-Androstanediol (Post-menopausal), 5b-Pregnanediol (male), 5b-Pregnanediol (Post-menopausal), 5b-Tetrahydrocorticosterone, 5b-Tetrahydrocortisol (male), 5b-Tetrahydrocortisol (Post-menopausal), 8-hydroxy-2’-deoxyguanosine (male), 8-hydroxy-2’-deoxyguanosine (Post-menopausal), Allopregnanolone (male), Allopregnanolone (Post-menopausal), Androstenedione (Male), Androstenedione (Post-menopausal), Androsterone (5a) / Etiocholanolone (5b) (male), Androsterone (5a) / Etiocholanolone (5b) (Post-menopausal), Androsterone (male), Androsterone (Post-menopausal), Corticosterone, Cortisol Bedtime, Cortisol Dinnertime, Cortisol Waking, Cortisol Waking+2hrs, Cortisol/Cortisone, Cortisol/day, Cortisone Bedtime, Cortisone Dinnertime, Cortisone Waking, Cortisone Waking+2hrs, Cortisone/day, Creatinine Bedtime (male), Creatinine Bedtime (Post-menopausal), Creatinine Dinnertime (male), Creatinine Dinnertime (Post-menopausal), Creatinine Waking (male), Creatinine Waking (Post-menopausal), Creatinine Waking+2hrs (male), Creatinine Waking+2hrs (Post-menopausal), Creatinine/day (male), Creatinine/day (Post-menopausal), Dehydroepiandrosterone (male), Dehydroepiandrosterone (Post-menopausal), Dehydroepiandrosterone Sulfate (male), Dehydroepiandrosterone Sulfate (Post-menopausal), DHEA+DHEAS (male), DHEA+DHEAS (Post-menopausal), EPI-Testosterone (male), EPI-Testosterone (Post-menopausal), Estradiol (male), Estradiol (Post-menopausal), Estriol (male), Estriol (Post-menopausal), Estrone (male), Estrone (Post-menopausal), Etiocholanolone (male), Etiocholanolone (Post-menopausal), Progesterone (male), Progesterone (Post-menopausal), Testosterone (male), Testosterone (Post-menopausal), Testosterone / EPI-Testosterone (male), Testosterone / EPI-Testosterone (Post-menopausal), Tetrahydrocortisone (male), Tetrahydrocortisone (Post-menopausal), Tetrahydrodehydrocorticosterone, THE+5A-THF+5B-THF (male), THE+5A-THF+5B-THF (Post-menopausal)