2-Hydroxyestrone (Post-menopausal)

Optimal Result: 1.6 - 6.5 ng/mg Creat/Day.

What does it mean if your 2-Hydroxyestrone (Post-menopausal) result is too low?

Adequate levels of 2-OH-E1 have been shown to be a favorable marker for breast health. Low levels of 2-OH E1 may be due to low levels of estrone, or more active CYP3A4 or CYP1B1 enzymes. Increasing the activity of CYP1A1 to increase 2-OH-E1 is a consideration.

What does it mean if your 2-Hydroxyestrone (Post-menopausal) result is too high?

Adequate levels of 2-OH-E1 have been shown to be a favorable marker for breast health. Elevated levels can be due to high endogenous estrone as well as exogenous exposure to or supplementation of estrone and/or estradiol. While 2-OH-E1 is considered the “safer” estrogen metabolite, optimizing methylation to support the COMT enzyme will ensure favorable excretion rates.

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