Dehydroepiandrosterone Sulfate (male)

Elevated (males): Dehydroepiandrosterone sulfate or DHEA-S is the sulfated form of dehydroepiandrosterone (DHEA) and the major steroid precursor in humans. This sulfation is reversibly catalyzed by sulfotransferase 2A1 (SULT2A1) primarily in the adrenals, the liver, and the small intestine. Like DHEA, research suggests DHEA-S elevations could be due to adult-onset adrenal hyperplasia, congenital adrenal hyperplasia, and very rarely adrenal carcinoma. Increased levels of DHEA, as well as pregnenolone, through either supplementation or endogenous excretion, may also contribute to elevated levels of DHEAS.

Dehydroepiandrosterone sulfate (DHEA-S), the sulfated form of dehydroepiandrosterone (DHEA), is primarily produced by the zona reticularis of the adrenal glands and serves as a reservoir for DHEA. Like DHEA, DHEA-S naturally declines with age. Research suggests symptoms of declining DHEA-S can manifest as declining cognition, libido, mood, flexibility, and cardiovascular health.

Dehydroepiandrosterone sulfate or DHEA-S is the sulfated form of dehydroepiandrosterone (DHEA) and the major steroid precursor in humans. This sulfation is reversibly catalyzed by sulfotransferase 2A1 (SULT2A1) primarily in the adrenals, the liver, and the small intestine.