EPI-T is a naturally occurring mirror-image form of testosterone. Unlike testosterone, it has very weak androgenic effects and can act as a mild androgen receptor blocker (weak antiandrogen). It may also modestly inhibit 5-α-reductase, the enzyme that converts testosterone to DHT. In pre-menopausal women, EPI-T levels are low compared with typical male levels and help round out the picture of androgen metabolism on a urine hormone panel.
On its own, EPI-T is not a disease marker and rarely drives symptoms. Its value is contextual: paired with testosterone, DHEA(S), androstenedione, DHT and 5-α/5-β metabolites, it helps your clinician see whether your body is favoring androgen activity (e.g., more 5-α reduction) or showing a counter-balancing pattern (relatively higher EPI-T). Because EPI-T binds weakly to the androgen receptor, a higher EPI-T does not equal “more androgen effects.”
Within range: Typical for pre-menopausal women and consistent with balanced androgen metabolism.
Lower than range: Usually not clinically significant by itself. Consider overall androgen status (very low testosterone or DHEA), hormonal contraception effects, under-eating, or high endurance training if symptomatic (fatigue, low libido).
Higher than range: Often reflects individual metabolic variation rather than pathology. Review recent alcohol intake (can transiently increase EPI-T), supplements/medications, and the broader androgen pattern. Persistent elevation with androgen-excess symptoms (acne, hirsutism, scalp hair thinning, irregular cycles) warrants a comprehensive evaluation of testosterone, free T, SHBG, DHEA-S, androstenedione, and 5-α/5-β metabolites.
Note: Exogenous testosterone therapy can raise testosterone without proportionally raising EPI-T, so EPI-T may appear relatively unchanged on urine testing.
Alcohol: Intake before collection can increase EPI-T transiently.
Medications/supplements: Agents that influence 5-α-reductase (e.g., finasteride/dutasteride) or overall steroid metabolism may change the pattern.
Hormonal contraception & cycle phase: Can alter androgen production/clearance; interpret alongside cycle day and medication use.
Training, energy availability, stress: Heavy training, under-fueling, or high stress can shift steroid hormones modestly.
If your EPI-T is in range and you feel well, no EPI-T-specific action is needed—interpret it with the rest of your panel.
If borderline/high, and especially if unexpected:
Repeat with a first-morning urine sample, follow collection instructions, and avoid alcohol for 24–48 hours prior.
Review meds/supplements and note cycle day or contraception.
Discuss a broader androgen workup if you have symptoms: total & free testosterone, SHBG, DHEA-S, androstenedione, and 5-α/5-β metabolites (e.g., androsterone, etiocholanolone, 5-α-androstanediol).
If you’re on or considering testosterone therapy, interpret EPI-T in context; it is not a reliable indicator of dose adequacy or tissue androgen effect by itself.
Think of EPI-T as a supporting actor that helps explain the overall androgen story. A result out of range is rarely diagnostic alone—the pattern across testosterone, DHEA-S, DHT pathways, and SHBG plus your symptoms leads to useful clinical decisions.
Is a high EPI-T dangerous?
Not typically. EPI-T has weak antiandrogen properties. Persistent highs should be interpreted with symptoms and companion markers.
Does EPI-T diagnose PCOS or androgen disorders?
No. It’s a context marker. Diagnosis relies on clinical features and a full hormone panel.
Can I improve my numbers?
Focus on consistent collection, adequate sleep/nutrition, moderating alcohol, and working with your clinician if you have androgen-related symptoms.
Your medical lab tests hold vital information about your health. Our tools help you understand what's going on and how to take action.
Cancel or upgrade anytime
An elevated EPI-testosterone (epitestosterone) result means the mirror-image form (epimer) of testosterone is higher than your lab’s reference range for pre-menopausal women. EPI-T has weak antiandrogen activity and may mildly inhibit 5-α-reductase (the enzyme that makes DHT). On its own, a higher EPI-T does not mean “too much testosterone” or guarantee androgen-related symptoms. It’s primarily a context marker that helps your clinician understand your overall androgen pathway alongside testosterone, DHEA-S, androstenedione, DHT, and 5-α/5-β metabolites.
Physiologic variation: Some people naturally produce/clear more EPI-T. Inter-individual differences and day-to-day variability are common.
Alcohol intake: Drinking before collection can transiently raise EPI-T; even moderate use the evening prior may shift a borderline result.
Medications & supplements: Agents that influence steroid metabolism or 5-α-reductase (e.g., finasteride/dutasteride, certain botanicals) can change the pattern of androgen metabolites.
Cycle phase & hormones: Hormonal contraception, luteal vs. follicular testing, perimenstrual stress, and sleep/energy status can subtly alter steroid output and clearance.
Laboratory/collection factors: Urine hormone testing is usually normalized to creatinine; very dilute or concentrated samples, or non–first-morning collections, can nudge near-cutoff values.
Note: In anti-doping, EPI-T is used with testosterone to form a T/E ratio because EPI-T tends to be less affected by exogenous testosterone. That forensic use doesn’t change clinical interpretation in health care.
Slightly/borderline elevated: Often due to recent alcohol, collection timing, or normal variability. Re-check under controlled conditions.
Persistently or clearly elevated: Review symptoms and the broader androgen profile. A higher EPI-T by itself rarely explains acne, hirsutism, scalp hair thinning, or cycle irregularity; look for parallel changes in testosterone (total/free), DHEA-S, androstenedione, DHT, 5-α-reduced metabolites, and SHBG.
If you have androgen-excess symptoms: They typically correlate more with testosterone/DHT activity than with EPI-T. Elevated EPI-T alone is not diagnostic of PCOS or other androgen disorders.
If you feel well and other androgens are normal: An isolated EPI-T elevation is often benign and monitored rather than treated.
Repeat correctly if the result is unexpected or borderline: first-morning urine, follow collection instructions, and avoid alcohol for 24–48 hours beforehand.
Review medications/supplements that can influence androgen pathways (5-α-reductase inhibitors, prohormones, certain botanicals).
Assess the pattern with companion tests: total and free testosterone, SHBG, DHEA-S, androstenedione, DHT, and 5-α/5-β metabolites (e.g., androsterone, etiocholanolone).
Discuss symptoms & goals with your clinician. Management—if any—targets the underlying pattern (e.g., excess 5-α reduction, insulin resistance, sleep/stress factors), not the EPI-T number alone.
Lifestyle levers: Consistent sleep, balanced nutrition, resistance training plus moderate cardio, and limiting alcohol can stabilize steroid patterns over time.
EPI-T is a supporting marker, not a stand-alone diagnosis.
A higher EPI-T does not automatically mean higher androgen effects; it may even reflect counter-balancing antiandrogen activity.
Re-test under optimal conditions and interpret with the entire androgen profile and your symptoms.
Anthony
Unlimited Plan Member since 2021
I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
Karin
Advanced Plan Member since 2020
What fantastic service and great, easy-to-follow layouts! I love your website; it makes it so helpful to see patterns in my health data. It's truly a pleasure to use. I only wish the NHS was as organized and quick as Healthmatters.io. You've set a new standard for health tracking!
Paul
Healthmatters Pro Member since 2024
As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
Guiding our users for 10 years to promptly understand, track, and act on their laboratory results.
$15/month
Cancel your subscription at any time.
$250/once
full premium version
$45/month
track your clients’ labs
Cancel your subscription at any time.
Guiding our users for 10 years to promptly understand, track, and act on their laboratory results.
Personal plans
track personal results
Professional Plan
track multiple client's results
$15/month
$250/once
own it for life
$45/month
for health professionals
Complete Plan
Unlimited Plan
$15 / month
$250 full version
Are you a health professional?
Level up your lab report analysis with our Pro plan, built for health practitioners like you.
Health Business Account
$45/month
Cancel your subscription at any time.
Unlock additional Pro plans when you sign up.
Anthony
Unlimited Plan Member since 2021
I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
Karin
Advanced Plan Member since 2020
What fantastic service and great, easy-to-follow layouts! I love your website; it makes it so helpful to see patterns in my health data. It's truly a pleasure to use. I only wish the NHS was as organized and quick as Healthmatters.io. You've set a new standard for health tracking!
Paul
Healthmatters Pro Member since 2024
As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
Healthmatters is a highly-personalized health dashboard.
Instead of searching for your lab results in different places or tracking them down from different providers, Healthmatters houses, organizes, and interprets them all in one central location.
With a Healthmatters account, you can dive into the details of each biomarker and gain insights into the meaning behind your medical test data, anytime, anywhere.
For our professional users, Healthmatters provides intuitive tools that not only streamline analysis but also save valuable time when delving into your client's lab report history.
Healthmatters.io personal account provides in-depth research on 4000+ biomarkers, including information and suggestions for test panels such as, but not limited to:
You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.
If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
While we work with many popular labs, we welcome reports from lots of other places too.
It's as simple as this: if you can get a test done, you can upload it to Healthmatters and we can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.
If you’re on the hunt for a specific biomarker, contact us and we'll add it to our database. Anything from blood, urine, saliva, or stool can be uploaded, understood, and tracked with your Healthmatters account.
There are two ways to add your test reports to your Healthmatters account. One option is to input the data using the data entry forms. The other method is to utilize our "Data entry service."
Our data entry forms offer an easy, fast, and free way for you to input the reports yourself. Self-entry allows you to add an unlimited number of reports at no cost. We make the self-entry process user-friendly, providing dozens of templates that pre-populate the most popular laboratory panels and offering instant feedback on entered values.
For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you.
We support various file types, including PDFs, JPGs, or Excel. This service is particularly useful if you have many reports to upload or if you're too busy to handle the data entry yourself.
Our special data entry service makes it easy to add your results to your private dashboard. Just attach an image or a file of your lab test results, and our skilled data entry team will do the work for you. It's all done by humans, ensuring that your data is entered accurately and with personal care for each client.
Depending on your account, the data entry service can be included for free or come at an additional cost of $15 per report.
For users on the Complete monthly plan, the first report is entered free of charge, and each additional report incurs a fee of $15.
Unlimited account holders enjoy the entry of ten reports without charge. Subsequent reports are subject to a $15 fee per report.
Additionally, users on the Complete plan can upgrade to a yearly subscription from the account settings. The annual subscription includes a data entry service for five reports.
The Unlimited plan is a one-time purchase for $250, and it covers your account for a lifetime with no additional payments.
For the Complete plan, the cost is $15 per month. You have the flexibility to cancel it anytime through your account settings, ensuring no further payments. To avoid charges, remember to cancel at least a day before the renewal date. Once canceled, the subscription remains active until the end of the current billing cycle.
Additionally, you can upgrade to the yearly Advanced plan from within your account. The annual cost is $79, and it comes with a data entry service for five reports.
You can always upgrade to a lifetime version with a prorated price from a monthly or yearly subscription.
Simply log in and navigate to your account settings to cancel your subscription. Scroll down to locate the 'Cancel' button at the bottom of the page. Ensure you cancel at least one day before the renewal date to prevent any charges. Once cancellation is requested, the subscription remains active until the conclusion of the current billing cycle.
Our goal has been to make your Healthmatters account as intuitive as possible.
We’ve crafted multiple ways for you to navigate your data, whether you're glancing at a single report or delving into your historical test reports.
1. Graph View:Dive into a visual journey with our biomarker graphs, showcasing over 40 data points. Combining years of results unveils trends, empowering you to make informed decisions. Our visualization tools make it a breeze to compare and understand changes over time, even if your results are from different labs. A search function and filters simplify the exploration of extensive data, allowing you to focus on what needs attention.
2. All Tests ViewExplore neatly organized reports on a timeline, highlighting crucial details like dates, critical results, and lab/panel names. Each report opens up to reveal in-depth descriptions and additional recommendations for each biomarker. The history of previous results is just a click away, and you can download a comprehensive report for deeper insights. Color-coded and user-friendly, it's designed for easy reading, understanding, and navigation.
3. Table View:For a holistic view of all biomarkers side by side, our table view is your go-to. Results are neatly displayed in a categorized and dated table, ideal for those with an extensive test history. Utilize sorting, filters, and color-coding to enhance your analysis and gain extra insights.
Yes, you can download information from your account. We can compile your labs into a CSV file. To download all your labs, you can go to Account Settings, and at the bottom of the page, you will find a link to download your information.
Yes, you can print your report. To do so, navigate to "All tests" and open the report you wish to print. You'll find a print button in the right corner of the report. Click on it, and your browser's print window will open. If you prefer to print in a bigger typeface, adjust the scale using the print window settings.
Yes, you can! We highly recommend activating Two-Factor Authentication (2FA) for your account. To do so, please navigate to the "Profile and Security" section of your account, where you will find instructions for activating 2FA.
Yes, you can. When entering values for the biomarker, you will see an "Edit Range" button. Click this button, and you'll have the option to enter a custom range.
A personal account is all about keeping your own lab test results in check. It's just for you and your personal use.
The professional account is designed for health professionals who wish to track and organize their clients' laboratory results.
To learn more about Healthmatters Pro, please refer to the professional page.
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.
1-hydroxy-Etiocholanolone (Post-menopausal), 11-Deoxycortisol (male), 11-Deoxycortisol (Post-menopausal), 11-Deoxycortisol (Pre-menopausal), 11-hydroxy-Androsterone (male), 11-hydroxy-Androsterone (Post-menopausal), 11-hydroxy-Androsterone (Pre-menopausal), 11-hydroxy-Etiocholanolone (male), 11-hydroxy-Etiocholanolone (Post-menopausal), 11-hydroxy-Etiocholanolone (Pre-menopausal), 16-OH-E1 % (male), 16-OH-E1 % (Post-menopausal), 16-OH-E1 % (Pre-menopausal), 16a-Hydroxyestrone (male), 16a-Hydroxyestrone (Post-menopausal), 16a-Hydroxyestrone (Pre-menopausal), 17-Hydroxyprogesterone (male), 17-Hydroxyprogesterone (Post-menopausal), 17-Hydroxyprogesterone (Pre-menopausal), 2-Hydroxyestradiol (male), 2-Hydroxyestradiol (Post-menopausal), 2-Hydroxyestradiol (Pre-menopausal), 2-Hydroxyestrone (male), 2-Hydroxyestrone (Post-menopausal), 2-Hydroxyestrone (Pre-menopausal), 2-M-E1:2-OH-E1 (male), 2-M-E1:2-OH-E1 (Post-menopausal), 2-M-E1:2-OH-E1 (Pre-menopausal), 2-M-E2:2-OH-E2 (male), 2-M-E2:2-OH-E2 (Post-menopausal), 2-M-E2:2-OH-E2 (Pre-menopausal), 2-Methoxyestradiol (male), 2-Methoxyestradiol (Post-menopausal), 2-Methoxyestradiol (Pre-menopausal), 2-Methoxyestrone (male), 2-Methoxyestrone (Post-menopausal), 2-Methoxyestrone (Pre-menopausal), 2-OH-E1 % (male), 2-OH-E1 % (Post-menopausal), 2-OH-E1 % (Pre-menopausal), 2-OH-E1:16-OH-E1 (male), 2-OH-E1:16-OH-E1 (Post-menopausal), 2-OH-E1:16-OH-E1 (Pre-menopausal), 21-Hydroxyprogesterone (male), 21-Hydroxyprogesterone (Post-menopausal), 21-Hydroxyprogesterone (Pre-menopausal), 4-Hydroxyestradiol (male), 4-Hydroxyestradiol (Post-menopausal), 4-Hydroxyestradiol (Pre-menopausal), 4-Hydroxyestrone (male), 4-Hydroxyestrone (Post-menopausal), 4-Hydroxyestrone (Pre-menopausal), 4-M-E1:4-OH-E1 (male), 4-M-E1:4-OH-E1 (Post-menopausal), 4-M-E1:4-OH-E1 (Pre-menopausal), 4-M-E2:4-OH-E2 (male), 4-M-E2:4-OH-E2 (Post-menopausal), 4-M-E2:4-OH-E2 (Pre-menopausal), 4-Methoxyestradiol (male), 4-Methoxyestradiol (Post-menopausal), 4-Methoxyestradiol (Pre-menopausal), 4-Methoxyestrone (male), 4-Methoxyestrone (Post-menopausal), 4-Methoxyestrone (Pre-menopausal), 4-OH-E1 % (male), 4-OH-E1 % (Post-menopausal), 4-OH-E1 % (Pre-menopausal), 4-OH-E1:2-OH-E1 (male), 4-OH-E1:2-OH-E1 (Post-menopausal), 4-OH-E1:2-OH-E1 (Pre-menopausal), 5-pregnenetriol (male), 5-pregnenetriol (Post-menopausal), 5-pregnenetriol (Pre-menopausal), 5a-Androstanediol (male), 5a-Androstanediol (Post-menopausal), 5a-Androstanediol (Pre-menopausal), 5a-Dihydrotestosterone (male), 5a-Dihydrotestosterone (Post-menopausal), 5a-Dihydrotestosterone (Pre-menopausal), 5A-PD:5B-PD (male), 5A-PD:5B-PD (Post-menopausal), 5A-PD:5B-PD (Pre-menopausal), 5a-Pregnanediol (male), 5a-Pregnanediol (Post-menopausal), 5a-Pregnanediol (Pre-menopausal), 5a-Tetrahydrocorticosterone, 5a-Tetrahydrocorticosterone (Pre-menopausal), 5a-Tetrahydrocortisol (male), 5a-Tetrahydrocortisol (Post-menopausal), 5a-Tetrahydrocortisol (Pre-menopausal), 5A-THF+5B-THF/THE (male), 5A-THF+5B-THF/THE (Post-menopausal), 5A-THF+5B-THF/THE (Pre-menopausal), 5A-THF/5B-THF ratio (male), 5A-THF/5B-THF ratio (Post-menopausal), 5A-THF/5B-THF ratio (Pre-menopausal), 5b-Androstanediol (male), 5b-Androstanediol (Post-menopausal), 5b-Androstanediol (Pre-menopausal), 5b-Pregnanediol (male), 5b-Pregnanediol (Post-menopausal), 5b-Pregnanediol (Pre-menopausal), 5b-Tetrahydrocorticosterone, 5b-Tetrahydrocorticosterone (Pre-menopausal), 5b-Tetrahydrocortisol (male), 5b-Tetrahydrocortisol (Post-menopausal), 5b-Tetrahydrocortisol (Pre-menopausal), 8-hydroxy-2-deoxyguanosine (Pre-menopausal), 8-hydroxy-2’-deoxyguanosine (male), 8-hydroxy-2’-deoxyguanosine (Post-menopausal), Allopregnanolone (male), Allopregnanolone (Post-menopausal), Allopregnanolone (Pre-menopausal), Androstenedione (Male), Androstenedione (Post-menopausal), Androstenedione (Pre-menopausal), Androsterone (5a) / Etiocholanolone (5b) (male), Androsterone (5a) / Etiocholanolone (5b) (Post-menopausal), Androsterone (5a) / Etiocholanolone (5b) (Pre-menopausal), Androsterone (male), Androsterone (Post-menopausal), Androsterone (Pre-menopausal), Corticosterone, Corticosterone (Pre-menopausal), Cortisol Bedtime, Cortisol Bedtime (Pre-menopausal), Cortisol Dinnertime, Cortisol Dinnertime (Pre-menopausal), Cortisol Waking, Cortisol Waking (Pre-menopausal), Cortisol Waking+2hrs, Cortisol Waking+2hrs (Pre-menopausal), Cortisol/Cortisone, Cortisol/Cortisone (Pre-menopausal), Cortisol/day, Cortisol/day (Pre-menopausal), Cortisone Bedtime, Cortisone Bedtime (Pre-menopausal), Cortisone Dinnertime, Cortisone Dinnertime (Pre-menopausal), Cortisone Waking, Cortisone Waking (Pre-menopausal), Cortisone Waking+2hrs, Cortisone Waking+2hrs (Pre-menopausal), Cortisone/day, Cortisone/day (Pre-menopausal), Creatinine Bedtime (male), Creatinine Bedtime (Post-menopausal), Creatinine Bedtime (Pre-menopausal), Creatinine Dinnertime (male), Creatinine Dinnertime (Post-menopausal), Creatinine Dinnertime (Pre-menopausal), Creatinine Waking (male), Creatinine Waking (Post-menopausal), Creatinine Waking (Pre-menopausal), Creatinine Waking+2hrs (male), Creatinine Waking+2hrs (Post-menopausal), Creatinine Waking+2hrs (Pre-menopausal), Creatinine/day (male), Creatinine/day (Post-menopausal), Creatinine/day (Pre-menopausal), Dehydroepiandrosterone (male), Dehydroepiandrosterone (Post-menopausal), Dehydroepiandrosterone (Pre-menopausal), Dehydroepiandrosterone Sulfate (male), Dehydroepiandrosterone Sulfate (Post-menopausal), Dehydroepiandrosterone Sulfate (Pre-menopausal), DHEA+DHEAS (male), DHEA+DHEAS (Post-menopausal), DHEA+DHEAS (Pre-menopausal), EPI-Testosterone (male), EPI-Testosterone (Post-menopausal), EPI-Testosterone (Pre-menopausal), Estradiol (male), Estradiol (Post-menopausal), Estradiol (Pre-menopausal), Estriol (male), Estriol (Post-menopausal), Estriol (Pre-menopausal), Estrone (male), Estrone (Post-menopausal), Estrone (Pre-menopausal), Etiocholanolone (male), Etiocholanolone (Post-menopausal), Etiocholanolone (Pre-menopausal), Progesterone (male), Progesterone (Post-menopausal), Progesterone (Pre-menopausal), Testosterone (male), Testosterone (Post-menopausal), Testosterone (Pre-menopausal), Testosterone / EPI-Testosterone (male), Testosterone / EPI-Testosterone (Post-menopausal), Testosterone / EPI-Testosterone (Pre-menopausal), Tetrahydrocortisone (male), Tetrahydrocortisone (Post-menopausal), Tetrahydrocortisone (Pre-menopausal), Tetrahydrodehydrocorticosterone, Tetrahydrodehydrocorticosterone (Pre-menopausal), THE+5A-THF+5B-THF (male), THE+5A-THF+5B-THF (Post-menopausal), THE+5A-THF+5B-THF (Pre-menopausal)
