Progesterone (male)

Optimal Result: 0 - 0.34 ng/mg Creat/Day.

Progesterone is produced by the corpus luteum following ovulation and to a lesser extent by the adrenal glands in both sexes. While found in the urine in small amounts, progesterone can be seen as a clinical marker of luteal activity and theraputic oral progesterone administration.

The most important progesterone metabolite, pregnanediol (PDL), can serve as a urinary marker for endogenous progesterone levels and as an indicator of ovulation. PDL exists as two isomers, 5α-pregnanediol and 5β-pregnanediol. 5β-pregnanediol represents the majority end point of endogenous progesterone metabolism and appears to have little activity within the body, while 5α-pregnanediol, the lesser metabolite of PDL, can cross the blood brain barrier and may partially agonize GABA-A receptors. This action is possibly due to its role as
an immediate precursor to allopregnanolone. Allopregnanolone is a potent neuroactive steroid capable of binding the GABA-A receptor often leading to sedative and anxiolytic action. The calming action of allopregnanolone is often seen with orally supplemented progesterone, as the liver metabolizes a large portion of oral progesterone to the neuroactive steroid allopregnanolone.

What does it mean if your Progesterone (male) result is too low?

In males, progesterone is produced in both the testes and adrenal gland. Low/low range levels of progesterone may contribute to decreased sperm maturation and motility and may play a role in adverse prostate outcomes.

What does it mean if your Progesterone (male) result is too high?

In males, progesterone is produced in both the testes and adrenal glands. Elevated progesterone may be due to high dose pregnenolone supplementation, progesterone supplementation, exogenous progesterone exposure, increased HSD3A activity, reduced activity of CYP21A or CYP17A, and/or prostate pathology. In addition, elevations of both progesterone and pregnanediol, progesterone’s major metabolite, have been reported in 21-hydroxylase deficiency.

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