11-Deoxycortisol has very little glucocorticoid activity yet its role as an intermediate in cortisol creation may assist in understanding of impairment along this pathway. CYP21A (21-hydroxylase) is responsible for the conversion of 17-hydroxyprogesterone to 11-deoxycortisol.
11-Deoxycortisol has very little glucocorticoid activity yet its role as an intermediate in cortisol creation may assist in understanding of impairment along this pathway. CYP21A (21-hydroxylase) is responsible for the conversion of 17-hydroxyprogesterone to 11-deoxycortisol. 21-hydroxylase deficiency can lead to a decrease in the production of 11-deoxycortisol. A complete understanding of the corticoids may provide more clinical information.
11-Deoxycortisol has very little glucocorticoid activity yet it’s helpful to understand its role as an intermediate in cortisol creation and how it can contribute to impairment of the pathway. 11-Deoxycortisol is metabolized via CYP11B (11-beta hydroxylase) to cortisol. Elevations of 11-deoxycortisol maybe due to impairment of CYP11B, congenital adrenal hyperplasia, or andrenocortico tumors. Elevations of blood pressure due to a buildup of 11-deoxycortisol have been reported.
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