The relationship of the cortisol metabolites (5-alpha THF + THF) to cortisone metabolite (THE) is another tool in the assessment of the dominance of active cortisol or inactive cortisone.
The relationship of the cortisol metabolites (5-alpha THF + THF) to cortisone metabolite (THE) is another tool in the assessment of the dominance of active cortisol or inactive cortisone. A low ratio reflects a higher conversion rate of cortisol to cortisone which can be normal in some cases, or may be due to overt or subclinical thyroid pathology.
The relationship of the cortisol metabolites (5-alpha THF + THF) to cortisone metabolite (THE) is another tool in the assessment of the dominance of active cortisol or inactive cortisone. An elevated ratio means suppressed enzyme activity or low conversion rate of cortisol to cortisone. This can be seen in stress, hypertension, metabolic syndrome, insulin resistance, PCOS, depression, with cortisol
supplementation or high licorice dosages.
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