16-OH-E1 % (Pre-menopausal)
In a Hormone Metabolite Assessment Panel (HUMAP) for pre-menopausal women, the percentage of 16-Hydroxyestrone (16-OH-E1) is a critical marker for evaluating estrogen metabolism and its implications for health.
16-OH-E1 is a metabolite of estrogen, produced through the 16α-hydroxylation pathway, and is known for its strong estrogenic properties. In contrast to other estrogen metabolites that are less active, 16-OH-E1 has been linked to an increased risk of estrogen-sensitive conditions, such as certain types of breast and uterine cancers. It promotes the growth of estrogen-responsive tissues and can contribute to conditions associated with estrogen dominance. The percentage of 16-OH-E1 in a woman's hormonal profile is significant; a higher percentage can indicate an increased reliance on the 16α-hydroxylation pathway, potentially leading to an elevated risk for estrogen-related health issues. Factors that can influence the proportion of 16-OH-E1 include genetics, liver health, diet, lifestyle, and body composition, as obesity is known to affect estrogen metabolism. Thus, in a HUMAP panel, the 16-OH-E1 percentage is an important metric. It provides insights into the dominant pathways of estrogen metabolism in the body and helps in assessing the risk for conditions associated with high estrogenic activity. This understanding is crucial for guiding preventive and therapeutic strategies in managing hormonal health, especially in pre-menopausal women where hormonal balance is key to overall well-being.
What does it mean if your 16-OH-E1 % (Pre-menopausal) result is too high?
High levels of 16-Hydroxyestrone (16-OH-E1) in a pre-menopausal woman, as indicated in a Hormone Metabolite Assessment Panel (HUMAP), are significant as they point to an increased engagement in the 16α-hydroxylation pathway of estrogen metabolism. 16-OH-E1 is known for its potent estrogenic properties and has been associated with an elevated risk of estrogen-sensitive conditions, such as certain breast and uterine cancers.
Elevated levels suggest a higher production of this potent estrogen metabolite, which can lead to conditions related to estrogen dominance, characterized by symptoms like heavy menstrual bleeding, fibrocystic breasts, and mood swings. This metabolic tendency can be influenced by various factors, including genetics, obesity (as adipose tissue can contribute to estrogen production), liver function (which plays a crucial role in hormone metabolism), and lifestyle factors such as diet and physical activity. High levels of 16-OH-E1 might also impact the balance with other hormones, like progesterone, further complicating the hormonal milieu. Thus, in a pre-menopausal woman, high levels of 16-OH-E1 in a HUMAP panel necessitate a careful evaluation of estrogen metabolism and hormonal health. It underscores the need for potential interventions that might include dietary changes, lifestyle modifications, and possibly medical therapies to shift the balance of estrogen metabolism towards less potent pathways. Such interventions aim to mitigate the risks associated with high estrogenic activity and maintain overall hormonal balance and health.
All Your Lab Results.
One Simple Dashboard.
Import, Track, and Share Your Lab Results Easily
Import, Track, and Share Your Lab Results
Import lab results from multiple providers, track changes over time, customize your reference ranges, and get clear explanations for each result. Everything is stored securely, exportable in one organized file, and shareable with your doctor—or anyone you choose.
Cancel or upgrade anytime
What does it mean if your 16-OH-E1 % (Pre-menopausal) result is too low?
Low levels of 16-Hydroxyestrone (16-OH-E1) in a pre-menopausal woman, as assessed in a Hormone Metabolite Assessment Panel (HUMAP), can indicate certain aspects of estrogen metabolism and hormonal health. 16-OH-E1, produced through the 16α-hydroxylation pathway, is known for its potent estrogenic effects and has been linked to an increased risk of estrogen-sensitive conditions, like certain types of breast and uterine cancers. Therefore, lower levels of this metabolite generally suggest a reduced engagement in this pathway, potentially indicating a lower risk for conditions associated with high estrogenic activity. This could be a result of effective liver function, as the liver plays a significant role in hormone metabolism, or it might reflect dietary and lifestyle factors that favor less potent pathways of estrogen metabolism, such as the 2-hydroxylation pathway. Additionally, genetic factors might predispose an individual to metabolize estrogens differently, resulting in lower levels of 16-OH-E1. In the broader context of hormonal health, low levels of this metabolite, especially when coupled with a balanced overall estrogen metabolism profile, could be indicative of a favorable hormonal balance. This balance is important in pre-menopausal women not only for reducing the risk of estrogen-related disorders but also for maintaining overall reproductive health, bone density, and cardiovascular health. However, it's crucial to interpret these levels within the context of the entire hormonal panel and individual health factors, as hormonal health is multifaceted and influenced by a complex interplay of various factors.
Laboratories
Bring All Your Lab Results Together — In One Place
We accept reports from any lab, so you can easily collect and organize all your health information in one secure spot.
Pricing Table
Gather Your Lab History — and Finally Make Sense of It
Finally, Your Lab Results Organized and Clear
Personal plans
$79/ year
Advanced Plan
Access your lab reports, explanations, and tracking tools.
- Import lab results from any provider
- Track all results with visual tools
- Customize your reference ranges
- Export your full lab history anytime
- Share results securely with anyone
- Receive 5 reports entered for you
- Cancel or upgrade anytime
$250/ once
Unlimited Account
Pay once, access everything—no monthly fees, no limits.
- Import lab results from any provider
- Track all results with visual tools
- Customize your reference ranges
- Export your full lab history anytime
- Share results securely with anyone
- Receive 10 reports entered for you
- No subscriptions. No extra fees.
$45/ month
Pro Monthly
Designed for professionals managing their clients' lab reports
- Import lab results from any provider
- Track lab results for multiple clients
- Customize reference ranges per client
- Export lab histories and reports
- Begin with first report entered by us
- Cancel or upgrade anytime
About membership
What's included in a Healthmatters membership
Import Lab Results from Any Source
See Your Health Timeline
Understand What Your Results Mean
Visualize Your Results
Data Entry Service for Your Reports
Securely Share With Anyone You Trust
Let Your Lab Results Tell the Full Story
Once your results are in one place, see the bigger picture — track trends over time, compare data side by side, export your full history, and share securely with anyone you trust.
Bring all your results together to compare, track progress, export your history, and share securely.
What Healthmatters Members Are Saying
Frequently asked questions
Healthmatters is a personal health dashboard that helps you organize and understand your lab results. It collects and displays your medical test data from any lab in one secure, easy-to-use platform.
- Individuals who want to track and understand their health over time.
- Health professionals, such as doctors, nutritionists, and wellness coaches, need to manage and interpret lab data for their clients.
With a Healthmatters account, you can:
- Upload lab reports from any lab
- View your data in interactive graphs, tables, and timelines
- Track trends and monitor changes over time
- Customize your reference ranges
- Export and share your full lab history
- Access your results anytime, from any device
Professionals can also analyze client data more efficiently and save time managing lab reports.
Healthmatters.io personal account provides in-depth research on 10000+ biomarkers, including information and suggestions for test panels such as, but not limited to:
- The GI Effects® Comprehensive Stool Profile,
- GI-MAP,
- The NutrEval FMV®,
- The ION Profile,
- Amino Acids Profile,
- Dried Urine Test for Comprehensive Hormones (DUTCH),
- Organic Acids Test,
- Organix Comprehensive Profile,
- Toxic Metals,
- Complete Blood Count (CBC),
- Metabolic panel,
- Thyroid panel,
- Lipid Panel,
- Urinalysis,
- And many, many more.
You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.
If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
We implement proven measures to keep your data safe.
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.