The relationship of 4-M-E2 / 4-OH-E2 represents the activity of COMT (methylation) enzyme. A low ratio indicates slower COMT activity, which may mean a higher potential for the creation of quinones, semi-quinones, and depurinating adducts. Increasing COMT enzyme activity is a consideration.
The relationship of 4-M-E2 / 4-OH-E2 represents the activity of COMT (methylation). 4-OH-E2 is considered unfavorable due to its carcinogenic potential within breast tissue. Elevated COMT activity shows more of 4-OH-E1 is being methylated, which is considered favorable. Overtime, COMT enzyme may need additional support to keep up with demand. Comparing additional areas of COMT
activity (ie 2-M-E1/ 2-OH-E1) may give more insight into the function of this enzyme.
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