4-OH-E2 is associated with a higher risk of certain cancers and other negative markers for breast health in females. Due to the lack of research in this area, it may be postulated that males carry a similar risk.
4-OH-E2 is associated with a higher risk of certain cancers and other negative markers for breast health in females. Due to the lack of research in this area, it may be postulated that males carry a similar risk. Low levels may be beneficial depending on the other metabolites and methylation further down the pathway.
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Elevated levels are associated with higher risk of certain cancers and other negative markers of breast health in females. Due to the lack of research in this area, it may be postulated that males carry a similar risk. Elevation of 4-OH-E2 may be due to an overactive CYP1B1 enzyme or sluggish CYP1A1 or CYP3A4. Research indicates CYP1B1 is upregulated by PAHs, PCBs, THC, UV exposure, leptin resistance, inflammation, and insulin resistance. Supporting the COMT enzyme (methylation) is a consideration.
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11-Deoxycortisol (male), 11-hydroxy-Androsterone (male), 11-hydroxy-Etiocholanolone (male), 16-OH-E1 % (male), 16a-Hydroxyestrone (male), 17-Hydroxyprogesterone (male), 2-Hydroxyestradiol (male), 2-Hydroxyestrone (male), 2-M-E1:2-OH-E1 (male), 2-M-E2:2-OH-E2 (male), 2-Methoxyestradiol (male), 2-Methoxyestrone (male), 2-OH-E1 % (male), 2-OH-E1:16-OH-E1 (male), 21-Hydroxyprogesterone (male), 4-Hydroxyestradiol (male), 4-Hydroxyestrone (male), 4-M-E1:4-OH-E1 (male), 4-M-E2:4-OH-E2 (male), 4-Methoxyestradiol (male), 4-Methoxyestrone (male), 4-OH-E1 % (male), 4-OH-E1:2-OH-E1 (male), 5-pregnenetriol (male), 5a-Androstanediol (male), 5a-Dihydrotestosterone (male), 5A-PD:5B-PD (male), 5a-Pregnanediol (male), 5a-Tetrahydrocorticosterone (male), 5a-Tetrahydrocortisol (male), 5A-THF+5B-THF/THE (male), 5A-THF/5B-THF ratio (male), 5b-Androstanediol (male), 5b-Pregnanediol (male), 5b-Tetrahydrocorticosterone (male), 5b-Tetrahydrocortisol (male), 8-hydroxy-2’-deoxyguanosine (male), Allopregnanolone (male), Androstenedione (Male), Androsterone (5a) / Etiocholanolone (5b) (male), Androsterone (male), Corticosterone (male), Cortisol Bedtime (male), Cortisol Dinnertime (male), Cortisol Waking (male), Cortisol Waking+2hrs (male), Cortisol/Cortisone (male), Cortisol/day (male), Cortisone Bedtime (male), Cortisone Dinnertime (male), Cortisone Waking (male), Cortisone Waking+2hrs (male), Cortisone/day (male), Creatinine Bedtime (male), Creatinine Dinnertime (male), Creatinine Waking (male), Creatinine Waking+2hrs (male), Creatinine/day (male), Dehydroepiandrosterone (male), Dehydroepiandrosterone Sulfate (male), DHEA+DHEAS (male), EPI-Testosterone (male), Estradiol (male), Estriol (male), Estrone (male), Etiocholanolone (male), Progesterone (male), Testosterone (male), Testosterone / EPI-Testosterone (male), Tetrahydrocortisone (male), Tetrahydrodehydrocorticosterone (male), THE+5A-THF+5B-THF (male)
