16-OH-E1 % (Post-menopausal)

Optimal Result: 10 - 50 ng/mg Creat/Day.

Percentages of 2-OH-E1, 4-OH-E1, and 16-OH-E1

When evaluating phase I metabolism, it can be helpful to compare the percentages of 2, 4, and 16 OH-E1 metabolites. Most individuals metabolize the majority of their estrogens down the 2-OH-E1 pathway which is generally considered the “safer pathway”. This is followed by 16-OH-E1 and 4-OH-E1 respectively, both of which are deemed more reactive and potentially genotoxic.

What does it mean if your 16-OH-E1 % (Post-menopausal) result is too low?

Higher levels of 16-OH-E1 are associated with a higher risk of certain cancers and other negative markers of breast health in females. Elevations in 16-OH-E1 may be due to increased metabolism from estrone or a sluggish HSD17B enzyme, keeping 16-OH-E1 from converting into estriol.

What does it mean if your 16-OH-E1 % (Post-menopausal) result is too high?

Higher levels of 16-OH-E1 are associated with a higher risk of certain cancers and other negative markers of breast health in females. Elevations in 16-OH-E1 may be due to increased metabolism from estrone or a sluggish HSD17B enzyme, keeping 16-OH-E1 from converting into estriol.

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