4-Hydroxyestrone (male)

Optimal Result: 0 - 0.5 ng/mg Creat/Day.

Higher levels indicate slowed COMT activity (methylation) and are associated with a higher risk for breast cancer in females. Due to the lack of research in this area, it may be postulated that men carry a similar risk. Elevation may also be due to an overactive CYP1B1 enzyme or sluggish CYP1A1 or CYP34A. Additional support for the COMT enzyme can help with the conversion toward the inactive
metabolite, 4-M-E1.

What does it mean if your 4-Hydroxyestrone (male) result is too low?

4-OH E1 is associated with a higher risk of certain cancers and other markers for breast health in women. Due to the lack of research in men, it may be postulated that men carry similar risks. Low levels may be beneficial depending on the other metabolites and methylation further down the pathway.

What does it mean if your 4-Hydroxyestrone (male) result is too high?

Higher levels indicate slowed COMT activity (methylation) and are associated with a higher risk for breast cancer in females. Due to the lack of research in this area, it may be postulated that men carry a similar risk. Elevation may also be due to an overactive CYP1B1 enzyme or sluggish CYP1A1 or CYP34A. Additional support for the COMT enzyme can help with the conversion toward the inactive
metabolite, 4-M-E1.

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