4-M-E1:4-OH-E1 (Post-menopausal)

Optimal Result: 0.09 - 1 Ratio.

What does it mean if your 4-M-E1:4-OH-E1 (Post-menopausal) result is too low?

The relationship of 4-M-E1 / 4-OH-E1 represents the activity of COMT (methylation) enzyme. A low ratio indicates slower COMT activity, which may mean a higher potential for the creation of quinones, semi-quinones, and depurinating adducts. Increasing COMT enzyme activity is a consideration.

What does it mean if your 4-M-E1:4-OH-E1 (Post-menopausal) result is too high?

The relationship of 4-M-E1 / 4-OH-E1 represents the activity of COMT (methylation). 4-OH-E1 is considered unfavorable due to its carcinogenic potential within breast and prostatic tissue. Elevated COMT activity shows more of 4-OH-E1 is being methylated, which is considered favorable. Overtime, COMT enzyme may need additional support to keep up with demand. Comparing additional areas of COMT activity (ie 2-M-E1/ 2-OH-E1) may give more insight into the function of this enzyme.

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