4-Hydroxyestradiol (Post-menopausal)

Optimal Result: 0 - 0.45 ng/mg Creat/Day.

What does it mean if your 4-Hydroxyestradiol (Post-menopausal) result is too low?

4-OH-E2 is associated with a higher risk of certain cancers and other negative markers for breast health in women. Low levels may be beneficial depending on the other metabolites and methylation further down the pathway.

What does it mean if your 4-Hydroxyestradiol (Post-menopausal) result is too high?

Elevated levels are associated with higher risk of certain cancers and other negative markers of breast health in females. Elevation of 4-OH-E2 may be due to an overactive CYP1B1 enzyme or sluggish CYP1A1 or CYP3A4. Research indicates CYP1B1 is upregulated by PAHs, PCBs, THC, UV exposure, leptin resistance, inflammation, and insulin resistance. Supporting the COMT enzyme (methylation) is a
consideration.

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