Androsterone is the product of androgens metabolized by 5-alpha reductase. It acts as a neurosteroid and a weak potentiator of GABA-A receptor activity.
Androsterone is the product of androgens metabolized by 5-alpha reductase. It acts as a neurosteroid and a weak potentiator of GABA-A receptor activity. Inhibiting 5-alpha reductase lowers AN. 24-hour urine testing has shown that AN declines along with DHEA. Low levels may also be associated with adrenal insufficiency, anorexia nervosa and panhypopituitarism.
Androsterone is the product of androgens metabolized by 5-alpha reductase. It acts as a neurosteroid and a weak potentiator of GABA-A receptor activity. Androsterone may also be converted to DHT via backdoor pathway using HSD3B and HSD17B making it a metabolic intermediate. Potential causes of AN elevation may include PCOS, over supplementation of DHEA or pregnenolone, androgen producing gonadal tumors, congenital adrenal hyperplasia, adult-onset adrenal hyperplasia, serious illness, shock, and burns.
Elevated androsterone levels in postmenopausal women can have various implications for their health. Androsterone is a type of androgen hormone, and its elevation may be associated with several factors:
→ Hyperandrogenism: Elevated androsterone levels can be a sign of hyperandrogenism, a condition characterized by an excess amount of androgens, including testosterone and related hormones, in the body. Hyperandrogenism can lead to symptoms such as hirsutism (excessive hair growth), acne, and irregular menstrual periods.
→ Cardiovascular Risk: High circulating androgen levels, including androsterone, have been linked to an unfavorable cardiovascular risk profile in postmenopausal women. This hormonal imbalance can increase the prevalence of subclinical atherosclerosis, potentially elevating the risk of heart disease and related issues.
→ Breast Cancer Risk: Postmenopausal women with elevated serum androgens, such as androsterone, may be at an increased risk of breast cancer. High concentrations of dehydroepiandrosterone sulfate (DHEAS), a precursor to androgens, have been associated with breast cancer risk in this population.
→ Virilizing Effects: Besides the potential health risks mentioned above, elevated androgens like androsterone can also lead to virilizing physical effects, such as the development of male secondary sexual characteristics in women. This can include voice deepening, clitoral enlargement, and changes in body composition.
It's important for postmenopausal women with elevated androsterone levels to consult with healthcare providers for a thorough evaluation and appropriate management. The treatment or intervention needed may depend on the specific symptoms and underlying causes of the elevated androsterone levels.
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