Androsterone is the product of androgens metabolized by 5-alpha reductase. It acts as a neurosteroid and a weak potentiator of GABA-A receptor activity.
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Androsterone is the product of androgens metabolized by 5-alpha reductase. It acts as a neurosteroid and a weak potentiator of GABA-A receptor activity. Androsterone may also be converted to DHT via backdoor pathway using HSD3B and HSD17B making it a metabolic intermediate. Potential causes of AN elevation may include PCOS, over supplementation of DHEA or pregnenolone, androgen producing gonadal tumors, congenital adrenal hyperplasia, adult-onset adrenal hyperplasia, serious illness, shock, and burns.
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Elevated androsterone levels in postmenopausal women can have various implications for their health. Androsterone is a type of androgen hormone, and its elevation may be associated with several factors:
→ Hyperandrogenism: Elevated androsterone levels can be a sign of hyperandrogenism, a condition characterized by an excess amount of androgens, including testosterone and related hormones, in the body. Hyperandrogenism can lead to symptoms such as hirsutism (excessive hair growth), acne, and irregular menstrual periods.
→ Cardiovascular Risk: High circulating androgen levels, including androsterone, have been linked to an unfavorable cardiovascular risk profile in postmenopausal women. This hormonal imbalance can increase the prevalence of subclinical atherosclerosis, potentially elevating the risk of heart disease and related issues.
→ Breast Cancer Risk: Postmenopausal women with elevated serum androgens, such as androsterone, may be at an increased risk of breast cancer. High concentrations of dehydroepiandrosterone sulfate (DHEAS), a precursor to androgens, have been associated with breast cancer risk in this population.
→ Virilizing Effects: Besides the potential health risks mentioned above, elevated androgens like androsterone can also lead to virilizing physical effects, such as the development of male secondary sexual characteristics in women. This can include voice deepening, clitoral enlargement, and changes in body composition.
It's important for postmenopausal women with elevated androsterone levels to consult with healthcare providers for a thorough evaluation and appropriate management. The treatment or intervention needed may depend on the specific symptoms and underlying causes of the elevated androsterone levels.
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Androsterone is the product of androgens metabolized by 5-alpha reductase. It acts as a neurosteroid and a weak potentiator of GABA-A receptor activity. Inhibiting 5-alpha reductase lowers AN. 24-hour urine testing has shown that AN declines along with DHEA. Low levels may also be associated with adrenal insufficiency, anorexia nervosa and panhypopituitarism.
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Unlimited Plan Member since 2021
I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
Karin
Advanced Plan Member since 2020
What fantastic service and great, easy-to-follow layouts! I love your website; it makes it so helpful to see patterns in my health data. It's truly a pleasure to use. I only wish the NHS was as organized and quick as Healthmatters.io. You've set a new standard for health tracking!
Paul
Healthmatters Pro Member since 2024
As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
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5A-THF+5B-THF/THE (Post-menopausal), 5A-THF+5B-THF/THE (Pre-menopausal), 5A-THF/5B-THF ratio (male), 5A-THF/5B-THF ratio (Post-menopausal), 5A-THF/5B-THF ratio (Pre-menopausal), 5b-Androstanediol (male), 5b-Androstanediol (Post-menopausal), 5b-Androstanediol (Pre-menopausal), 5b-Pregnanediol (male), 5b-Pregnanediol (Post-menopausal), 5b-Pregnanediol (Pre-menopausal), 5b-Tetrahydrocorticosterone, 5b-Tetrahydrocorticosterone (Pre-menopausal), 5b-Tetrahydrocortisol (male), 5b-Tetrahydrocortisol (Post-menopausal), 5b-Tetrahydrocortisol (Pre-menopausal), 8-hydroxy-2-deoxyguanosine (Pre-menopausal), 8-hydroxy-2’-deoxyguanosine (male), 8-hydroxy-2’-deoxyguanosine (Post-menopausal), Allopregnanolone (male), Allopregnanolone (Post-menopausal), Allopregnanolone (Pre-menopausal), Androstenedione (Male), Androstenedione (Post-menopausal), Androstenedione (Pre-menopausal), Androsterone (5a) / Etiocholanolone (5b) (male), Androsterone (5a) / Etiocholanolone (5b) (Post-menopausal), Androsterone (5a) / Etiocholanolone (5b) (Pre-menopausal), Androsterone (male), Androsterone (Post-menopausal), Androsterone (Pre-menopausal), Corticosterone, Corticosterone (Pre-menopausal), Cortisol Bedtime, Cortisol Bedtime (Pre-menopausal), Cortisol Dinnertime, Cortisol Dinnertime (Pre-menopausal), Cortisol Waking, Cortisol Waking (Pre-menopausal), Cortisol Waking+2hrs, Cortisol Waking+2hrs (Pre-menopausal), Cortisol/Cortisone, Cortisol/Cortisone (Pre-menopausal), Cortisol/day, Cortisol/day (Pre-menopausal), Cortisone Bedtime, Cortisone Bedtime (Pre-menopausal), Cortisone Dinnertime, Cortisone Dinnertime (Pre-menopausal), Cortisone Waking, Cortisone Waking (Pre-menopausal), Cortisone Waking+2hrs, Cortisone Waking+2hrs (Pre-menopausal), Cortisone/day, Cortisone/day (Pre-menopausal), Creatinine Bedtime (male), Creatinine Bedtime (Post-menopausal), Creatinine Bedtime (Pre-menopausal), Creatinine Dinnertime (male), Creatinine Dinnertime (Post-menopausal), Creatinine Dinnertime (Pre-menopausal), Creatinine Waking (male), Creatinine Waking (Post-menopausal), Creatinine Waking (Pre-menopausal), Creatinine Waking+2hrs (male), Creatinine Waking+2hrs (Post-menopausal), Creatinine Waking+2hrs (Pre-menopausal), Creatinine/day (male), Creatinine/day (Post-menopausal), Creatinine/day (Pre-menopausal), Dehydroepiandrosterone (male), Dehydroepiandrosterone (Post-menopausal), Dehydroepiandrosterone (Pre-menopausal), Dehydroepiandrosterone Sulfate (male), Dehydroepiandrosterone Sulfate (Post-menopausal), Dehydroepiandrosterone Sulfate (Pre-menopausal), DHEA+DHEAS (male), DHEA+DHEAS (Post-menopausal), DHEA+DHEAS (Pre-menopausal), EPI-Testosterone (male), EPI-Testosterone (Post-menopausal), EPI-Testosterone (Pre-menopausal), Estradiol (male), Estradiol (Post-menopausal), Estradiol (Pre-menopausal), Estriol (male), Estriol (Post-menopausal), Estriol (Pre-menopausal), Estrone (male), Estrone (Post-menopausal), Estrone (Pre-menopausal), Etiocholanolone (male), Etiocholanolone (Post-menopausal), Etiocholanolone (Pre-menopausal), Progesterone (male), Progesterone (Post-menopausal), Progesterone (Pre-menopausal), Testosterone (male), Testosterone (Post-menopausal), Testosterone (Pre-menopausal), Testosterone / EPI-Testosterone (male), Testosterone / EPI-Testosterone (Post-menopausal), Testosterone / EPI-Testosterone (Pre-menopausal), Tetrahydrocortisone (male), Tetrahydrocortisone (Post-menopausal), Tetrahydrocortisone (Pre-menopausal), Tetrahydrodehydrocorticosterone, Tetrahydrodehydrocorticosterone (Pre-menopausal), THE+5A-THF+5B-THF (male), THE+5A-THF+5B-THF (Post-menopausal), THE+5A-THF+5B-THF (Pre-menopausal)
