The relationship of 2-M-E2 / 2-OH-E2 represents the activity of COMT (methylation) enzyme. A low ratio indicates slower COMT activity. While 2-OH-E2 is considered a safe metabolite, it is still considered a reactive metabolite until methylated and inactivated. Comparing additional areas of COMT activity (ie 4-M-E1/ 4-OH-E1) may give more insight into the function of this enzyme.
The relationship of 2-M-E2 / 2-OH-E2 represents the activity of COMT (methylation). While 2-OH-E2 is considered a safe metabolite, it is still considered a reactive metabolite until methylated and inactivated. Elevated COMT activity shows more of 2-OH-E2 is being methylated, which is considered favorable. Over time, COMT enzyme may need additional support to keep up with demand. Comparing additional areas of COMT activity (ie 4-M-E1/ 4-OH-E1) may give more insight into the function of this enzyme.
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