2-Hydroxyestradiol (Post-menopausal)

Optimal Result: 0.03 - 0.29 ng/mg Creat/Day.

What does it mean if your 2-Hydroxyestradiol (Post-menopausal) result is too low?

Adequate levels of 2-OH-E2, the “safer” estrogen metabolite, have been shown to be a marker for breast health. Low levels of 2-OH-E2 may be due to low levels of estradiol, estrone, or more active CYP34A or CYP1B1 enzymes. Increasing the activity of CYP1A1 to increase 2-OH-E1 is a consideration.

What does it mean if your 2-Hydroxyestradiol (Post-menopausal) result is too high?

Adequate levels of 2-OH-E2 have been shown to be a marker for breast health. Elevated levels can be due to high endogenous estradiol as well as exogenous exposure or supplementation of estrone and/or estradiol. While 2-OH-E2 is considered the “safer” estrogen metabolite, optimizing its methylation and excretion via the COMT enzyme may be beneficial.

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