Metabolites of progesterone are measured in urine, including 5b-pregnanediol and 5a-pregnanediol. 5b-pregnanediol is inactive in the body but is the major metabolite of progesterone. 5a-pregnanediol is often a metabolite of more interest, as it can cross the blood brain barrier and up-regulate GABA activity and is considered neuroprotective to the brain. Both taken together represent the major metabolic end points for progesterone and can be used to represent total progesterone production.
Progesterone is produced by the corpus luteum following ovulation and to a lesser extent by the adrenal glands in both sexes. While found in the urine in small amounts, progesterone can be seen as a clinical marker of luteul activity and theraputic oral progesterone administration. The most important progesterone metabolite, pregnanediol (PDL), can serve as a urinary marker for endogenous progesterone levels and as an indicator of ovulation. PDL exists as two isomers, 5a-pregnanediol and 5b-pregnanediol. 5b-pregnanediol represents the majority end point of endogenous progesterone metabolism and appears to have little activity within the body, while 5α-pregnanediol, the lesser metabolite of PDL, can cross the blood brain barrier and may partially agonize GABA-A receptors. This action is possibly due to its role as an immediate precursor to allopregnanolone. Allopregnanolone is a potent neuroactive steroid capable of binding the GABA-A receptor often leading to sedative and anxiolytic action. The calming action of allopregnanolone is often seen with orally supplemented progesterone, as the liver metabolizes a large portion of oral progesterone to the neuroactive steroid allopregnanolone.
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If just one of the metabolites is high, his total progesterone in serum may be normal, or the patient could have a metabolic preference pushing the bulk of his metabolites one direction.
5a-reductase makes the a-pregnanediol metabolite and can be higher with inflammation, insulin resistance or obesity. Not much is known about the 5b-reductase enzyme, which makes b-pregnanediol.
Progesterone in men is positively associated with inflammation and tends to rise in response to higher testosterone production, high stress, and high cortisol.
High progesterone in men is also seen with liver issues.
→ Working on the root cause is the best approach.
If oral progesterone OR pregnenolone supplementation are used, please be aware these will increase progesterone metabolites in the urine due to first pass metabolism, but serum progesterone may not be elevated to the same degree as the urine implies.
5A-PD is a minor urinary metabolite of progesterone. Increased levels may be due to high levels of progesterone or pregnenolone, progesterone supplementation, or adrenocorticohyperplasia. 5A-PD may agonize GABA-A receptors.
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Lower levels of pregnanediol may be due to decreased progesterone or 5-alpha reductase activity.
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Anthony
Unlimited Plan Member since 2021
I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
Karin
Advanced Plan Member since 2020
What fantastic service and great, easy-to-follow layouts! I love your website; it makes it so helpful to see patterns in my health data. It's truly a pleasure to use. I only wish the NHS was as organized and quick as Healthmatters.io. You've set a new standard for health tracking!
Paul
Healthmatters Pro Member since 2024
As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
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1-hydroxy-Etiocholanolone (Post-menopausal), 11-Deoxycortisol (male), 11-Deoxycortisol (Post-menopausal), 11-Deoxycortisol (Pre-menopausal), 11-hydroxy-Androsterone (male), 11-hydroxy-Androsterone (Post-menopausal), 11-hydroxy-Androsterone (Pre-menopausal), 11-hydroxy-Etiocholanolone (male), 11-hydroxy-Etiocholanolone (Post-menopausal), 11-hydroxy-Etiocholanolone (Pre-menopausal), 16-OH-E1 % (male), 16-OH-E1 % (Post-menopausal), 16-OH-E1 % (Pre-menopausal), 16a-Hydroxyestrone (male), 16a-Hydroxyestrone (Post-menopausal), 16a-Hydroxyestrone (Pre-menopausal), 17-Hydroxyprogesterone (male), 17-Hydroxyprogesterone (Post-menopausal), 17-Hydroxyprogesterone (Pre-menopausal), 2-Hydroxyestradiol (male), 2-Hydroxyestradiol (Post-menopausal), 2-Hydroxyestradiol (Pre-menopausal), 2-Hydroxyestrone (male), 2-Hydroxyestrone (Post-menopausal), 2-Hydroxyestrone (Pre-menopausal), 2-M-E1:2-OH-E1 (male), 2-M-E1:2-OH-E1 (Post-menopausal), 2-M-E1:2-OH-E1 (Pre-menopausal), 2-M-E2:2-OH-E2 (male), 2-M-E2:2-OH-E2 (Post-menopausal), 2-M-E2:2-OH-E2 (Pre-menopausal), 2-Methoxyestradiol (male), 2-Methoxyestradiol (Post-menopausal), 2-Methoxyestradiol (Pre-menopausal), 2-Methoxyestrone (male), 2-Methoxyestrone (Post-menopausal), 2-Methoxyestrone (Pre-menopausal), 2-OH-E1 % (male), 2-OH-E1 % (Post-menopausal), 2-OH-E1 % (Pre-menopausal), 2-OH-E1:16-OH-E1 (male), 2-OH-E1:16-OH-E1 (Post-menopausal), 2-OH-E1:16-OH-E1 (Pre-menopausal), 21-Hydroxyprogesterone (male), 21-Hydroxyprogesterone (Post-menopausal), 21-Hydroxyprogesterone (Pre-menopausal), 4-Hydroxyestradiol (male), 4-Hydroxyestradiol (Post-menopausal), 4-Hydroxyestradiol (Pre-menopausal), 4-Hydroxyestrone (male), 4-Hydroxyestrone (Post-menopausal), 4-Hydroxyestrone (Pre-menopausal), 4-M-E1:4-OH-E1 (male), 4-M-E1:4-OH-E1 (Post-menopausal), 4-M-E1:4-OH-E1 (Pre-menopausal), 4-M-E2:4-OH-E2 (male), 4-M-E2:4-OH-E2 (Post-menopausal), 4-M-E2:4-OH-E2 (Pre-menopausal), 4-Methoxyestradiol (male), 4-Methoxyestradiol (Post-menopausal), 4-Methoxyestradiol (Pre-menopausal), 4-Methoxyestrone (male), 4-Methoxyestrone (Post-menopausal), 4-Methoxyestrone (Pre-menopausal), 4-OH-E1 % (male), 4-OH-E1 % (Post-menopausal), 4-OH-E1 % (Pre-menopausal), 4-OH-E1:2-OH-E1 (male), 4-OH-E1:2-OH-E1 (Post-menopausal), 4-OH-E1:2-OH-E1 (Pre-menopausal), 5-pregnenetriol (male), 5-pregnenetriol (Post-menopausal), 5-pregnenetriol (Pre-menopausal), 5a-Androstanediol (male), 5a-Androstanediol (Post-menopausal), 5a-Androstanediol (Pre-menopausal), 5a-Dihydrotestosterone (male), 5a-Dihydrotestosterone (Post-menopausal), 5a-Dihydrotestosterone (Pre-menopausal), 5A-PD:5B-PD (male), 5A-PD:5B-PD (Post-menopausal), 5A-PD:5B-PD (Pre-menopausal), 5a-Pregnanediol (male), 5a-Pregnanediol (Post-menopausal), 5a-Pregnanediol (Pre-menopausal), 5a-Tetrahydrocorticosterone, 5a-Tetrahydrocorticosterone (Pre-menopausal), 5a-Tetrahydrocortisol (male), 5a-Tetrahydrocortisol (Post-menopausal), 5a-Tetrahydrocortisol (Pre-menopausal), 5A-THF+5B-THF/THE (male), 5A-THF+5B-THF/THE (Post-menopausal), 5A-THF+5B-THF/THE (Pre-menopausal), 5A-THF/5B-THF ratio (male), 5A-THF/5B-THF ratio (Post-menopausal), 5A-THF/5B-THF ratio (Pre-menopausal), 5b-Androstanediol (male), 5b-Androstanediol (Post-menopausal), 5b-Androstanediol (Pre-menopausal), 5b-Pregnanediol (male), 5b-Pregnanediol (Post-menopausal), 5b-Pregnanediol (Pre-menopausal), 5b-Tetrahydrocorticosterone, 5b-Tetrahydrocorticosterone (Pre-menopausal), 5b-Tetrahydrocortisol (male), 5b-Tetrahydrocortisol (Post-menopausal), 5b-Tetrahydrocortisol (Pre-menopausal), 8-hydroxy-2-deoxyguanosine (Pre-menopausal), 8-hydroxy-2’-deoxyguanosine (male), 8-hydroxy-2’-deoxyguanosine (Post-menopausal), Allopregnanolone (male), Allopregnanolone (Post-menopausal), Allopregnanolone (Pre-menopausal), Androstenedione (Male), Androstenedione (Post-menopausal), Androstenedione (Pre-menopausal), Androsterone (5a) / Etiocholanolone (5b) (male), Androsterone (5a) / Etiocholanolone (5b) (Post-menopausal), Androsterone (5a) / Etiocholanolone (5b) (Pre-menopausal), Androsterone (male), Androsterone (Post-menopausal), Androsterone (Pre-menopausal), Corticosterone, Corticosterone (Pre-menopausal), Cortisol Bedtime, Cortisol Bedtime (Pre-menopausal), Cortisol Dinnertime, Cortisol Dinnertime (Pre-menopausal), Cortisol Waking, Cortisol Waking (Pre-menopausal), Cortisol Waking+2hrs, Cortisol Waking+2hrs (Pre-menopausal), Cortisol/Cortisone, Cortisol/Cortisone (Pre-menopausal), Cortisol/day, Cortisol/day (Pre-menopausal), Cortisone Bedtime, Cortisone Bedtime (Pre-menopausal), Cortisone Dinnertime, Cortisone Dinnertime (Pre-menopausal), Cortisone Waking, Cortisone Waking (Pre-menopausal), Cortisone Waking+2hrs, Cortisone Waking+2hrs (Pre-menopausal), Cortisone/day, Cortisone/day (Pre-menopausal), Creatinine Bedtime (male), Creatinine Bedtime (Post-menopausal), Creatinine Bedtime (Pre-menopausal), Creatinine Dinnertime (male), Creatinine Dinnertime (Post-menopausal), Creatinine Dinnertime (Pre-menopausal), Creatinine Waking (male), Creatinine Waking (Post-menopausal), Creatinine Waking (Pre-menopausal), Creatinine Waking+2hrs (male), Creatinine Waking+2hrs (Post-menopausal), Creatinine Waking+2hrs (Pre-menopausal), Creatinine/day (male), Creatinine/day (Post-menopausal), Creatinine/day (Pre-menopausal), Dehydroepiandrosterone (male), Dehydroepiandrosterone (Post-menopausal), Dehydroepiandrosterone (Pre-menopausal), Dehydroepiandrosterone Sulfate (male), Dehydroepiandrosterone Sulfate (Post-menopausal), Dehydroepiandrosterone Sulfate (Pre-menopausal), DHEA+DHEAS (male), DHEA+DHEAS (Post-menopausal), DHEA+DHEAS (Pre-menopausal), EPI-Testosterone (male), EPI-Testosterone (Post-menopausal), EPI-Testosterone (Pre-menopausal), Estradiol (male), Estradiol (Post-menopausal), Estradiol (Pre-menopausal), Estriol (male), Estriol (Post-menopausal), Estriol (Pre-menopausal), Estrone (male), Estrone (Post-menopausal), Estrone (Pre-menopausal), Etiocholanolone (male), Etiocholanolone (Post-menopausal), Etiocholanolone (Pre-menopausal), Progesterone (male), Progesterone (Post-menopausal), Progesterone (Pre-menopausal), Testosterone (male), Testosterone (Post-menopausal), Testosterone (Pre-menopausal), Testosterone / EPI-Testosterone (male), Testosterone / EPI-Testosterone (Post-menopausal), Testosterone / EPI-Testosterone (Pre-menopausal), Tetrahydrocortisone (male), Tetrahydrocortisone (Post-menopausal), Tetrahydrocortisone (Pre-menopausal), Tetrahydrodehydrocorticosterone, Tetrahydrodehydrocorticosterone (Pre-menopausal), THE+5A-THF+5B-THF (male), THE+5A-THF+5B-THF (Post-menopausal), THE+5A-THF+5B-THF (Pre-menopausal)
