Products of Protein Breakdown (Total)

A healthy result should fall into the range 1.8 - 9.9 micromol/g.

Products of Protein Breakdown, which includes isovalerate, valerate and isobutyrate are produced by bacterial fermentation of proteinaceous material (polypeptides and amino acids) in the distal colon.

Products of Protein Breakdown (Total) is a set of markers of undigested protein reaching the colon [L]:

- Isovalerate

- Valerate

- Isobutyrate

It is derived from bacterial fermentation of protein in the distal colon.

Normal protein digestion and absorption is relatively complete in the stomach and small intestine.


- Protein origin of the volatile fatty acids isobutyrate and isovalerate in human stool. [L]

Products of Protein Breakdown (Total) result calculator

insert the value from you Products of Protein Breakdown (Total) test result.

What does it mean if your Products of Protein Breakdown (Total) result is too low?

A decreased value of Products of Protein Breakdown (Total) indicate:

- decreased protein intake

- imbalanced bacterial levels,

- or intestinal inflammation.

What does it mean if your Products of Protein Breakdown (Total) result is too high?

Increased fecal Products of Protein Breakdown may be due to:

- Underlying gastrointestinal conditions such as exocrine pancreatic insufficiency (maldigestion)

- Bacterial overgrowth of the small intestine

- Excessive delivery of protein to the colon, (ex: hypochlorhydria)

- Insufficient pancreatic proteases

- Excessive protein intake

- Increased colonic protein due to a GI bleed, excess mucus, bacterial overgrowth

May indicate protein maldigestion and malabsorption resulting in colonic protein fermentation, and/or excessive delivery of protein to the colon.

Assess for and treat root causes of insufficient protein digestion:

- Hypochlorhydria: Assess for/reduce use of acid-blocking medications (as clinically indicated). Consider addition of betaine HCl (=stomach acid hydrochloric acid). Please discuss with your doctor.

- Pancreatic exocrine insufficiency: Evaluate fecal PE1 and support with PERT (=Pancreatic enzyme replacement therapy). Please discuss with your doctor.

Assess for excessive delivery of protein to the colon:

- High-protein diet?

- Bacterial overgrowth?

- GI irritation/inflammation, bleeding?

Review, evaluate, and treat any abnormal inflammatory biomarkers and/or infection.

If the below biomarkers are also elevated, it is suggested to perform a SIBO breath test:


- n-butyrate

- Fecal fat (total)

- Methanobrevibacter smithii

Are you concerned about your lab report?
Select your plan, upload your lab reports and we’ll provide you with a meaningful interpretation.

Basic Interpretation
  • Instant interpretation
  • Use self upload form
  • 800+ biomarkers explained
  • Nutrition Recommendations
  • Cancel anytime
Full Interpretation
  • Instant interpretation
  • We upload 4 reports for you
  • 800+ biomarkers explained
  • Nutrition Recommendations
  • Cancel anytime
  • Online support
Own It For Life
  • Unlimited access
  • No subscription
  • Instant interpretations
  • We upload 10 reports for you
  • 800+ biomarkers explained
  • Nutrition Recommendations
  • Dedicated support

Test results don't lie. Learn what is happening inside your body.

Health is not exactly rocket science. You just have to know what your body needs and doesn't need. Your medical tests contain that information. Upload them to our service and we’ll help you understand, organize, and act on them.

Get Started

Medical results explained and interpreted.


"I was really concerned about my lab results and my GP was not able to see me for another week. Through HealthMatters I was able to interpret my results instantly." thankfull female customer

"I've been keeping all my lab results in a spreadsheet, covering approximately 20 years. The HealthMatters team helped me upload that info into the cloud. I can show this data to my family and doctors now easily." thankful young female customer

"I had no idea what my lab results meant. Here I found all the biomarkers that I was looking for online. Finally, I have not only organized them all neatly in one place, but I am also grateful to be able to understand what they mean."

Privacy and security of personal data. HIPAA and GDPR compliant badges.

Your Privacy And Security

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put security measures in place to help protect against the loss, misuse or alteration of information under our control. We use procedural, physical and electronic security methods designed to prevent people who aren't authorized from getting access to this information. Our internal code of conduct adds additional privacy protection. See our Privacy Policy for more information.