This short-chain fatty acid (SCFA) is produced as a result of the fermentation of dietary fiber, particularly gums and pectins, by certain bacteria that inhabit the intestines (particularly probiotic bacteria such as Lactobacilli and Bifodobacteria species).
An n-butyrate level within the reference range is first and foremost then, an indicator that such health promoting bacteria are present in sufficient amounts. A low n-butyrate level in this respect may indicate a deficiency of beneficial bacteria while a high level suggests a general bacterial overgrowth caused by factors such as low stomach acid or high carbohydrate/fibre diets. In the former case probiotic supplements may be required while in the latter antibiotic therapy, whether drug-based or natural, may be needed.
n-Butyrate is the preferred fuel for the cells of the colon, helping to keep them healthy. In this role it helps to regulate the differentiation and proliferation of these cells and has been associated with a reduced risk of colon cancer. This SCFA is also important for controlling general inflammation of the GI tract since it reduces the production of pro-inflammatory immune chemicals such as tumor necrosis factor-alpha (TNF-a). Recent research has shown that through this mechanism n-butyrate may be helpful in digestive disease such as Crohn's disease and celiac disease.
If n-butyrate levels are low the suggested therapy is likely to be increasing fibre in the diet, particularly gums and pectins, and using probiotic and possibly butyrate supplements. Gums and pectins are found in large amounts in many fruits, particularly citrus fruits and harder fruits such as apples.
If n-butyrate levels are low the suggested therapy is likely to be increasing fiber in the diet, particularly gums and pectins, and using probiotic and possibly butyrate supplements. Gums and pectins are found in large amounts in many fruits, particularly citrus fruits and harder fruits such as apples.
Understand and improve your laboratory results with our health dashboard.
Upload your lab reports and get interpretation today.
Our technology helps to understand, combine, track, organize, and act on your medical lab test results.
Interpret Your Lab Results
Upload your lab report and we’ll interpret and provide you with recomendations today.Get Started
Get Started With Our Personal Plan
Are You a Health Professional?
Get started with our professional plan
Welcome to Healthmatters Pro.
Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place. Learn more
for health professionals
$45 per month
Acetate, Akkermansia muciniphila, Anaerotruncus colihominis, Anaerotruncus colihominis/massiliensis, Ancylostoma/Necator (Hookworm), Ascaris lumbricoides, Bacteroides uniformis, Bacteroides vulgatus, Bacteroides-Prevotella group, Barnesiella spp., Beta-glucuronidase, Bifidobacterium longum, Bifidobacterium longum subsp. longum, Bifidobacterium spp., Blastocystis spp., Butyrivibrio crossotus, Calprotectin, Candida albicans/dubliniensis, Capillaria philippinensis, Cholesterol, Citrobacter species, Clostridium spp., Collinsella aerofaciens, Coprococcus eutactus, Cryptosporidium parvum/hominis, Cyclospora cayetanensis, Desulfovibrio piger, Dientamoeba fragilis, Entamoeba histolytica, Enterobacter cloacae, Enterobius vermicularis, Enterococcus faecalis, Eosinophil Protein X, Escherichia coli, Faecalibacterium prausnitzii, Fecal Color, Fecal Consistency, Fecal Fat, Total, Fecal Occult Blood, Fecal secretory IgA, Firmicutes/Bacteroidetes (F/B Ratio), Fusobacterium spp., Giardia, Klebsiella oxytoca, Klebsiella species, Lactobacillus spp., Long-Chain Fatty Acids, Methanobrevibacter smithii, n-Butyrate %, n-Butyrate Concentration, Odoribacter spp., Oxalobacter formigenes, Pancreatic Elastase 1, Phocaeicola vulgatus, Phospholipids, Prevotella spp., Products of Protein Breakdown (Total), Propionate, Proteus mirabilis, Pseudoflavonifractor spp., Roseburia spp., Ruminococcus bromii, Ruminococcus spp., Short-Chain Fatty Acids (SCFA), Total, Triglycerides, Veillonella spp., Zonulin Family Peptide