Oxalobacter formigenes is a bacterium that colonizes the colon of a substantial proportion of the normal population and metabolizes dietary and endogenous oxalate and hence reducing the incidence of kidney stones.
More about kidney stones:
Kidney stones are hard deposits made of minerals and salts that form inside your kidneys. Kidney stones are common, affecting 1 in 11 people in the United States. The most common form of the condition is the calcium oxalate stone. Current treatments include dietary modification, medications, and surgical treatment. Dietary modifications include increasing fluids, increasing dietary calcium, and decreasing oxalate in the diet (e.g. spinach, rhubarb, potatoes, nuts), and avoiding high dose Vitamin C. Medications may be used to reduce calcium in the urine or to reduce uric acid levels.
Oxalate degradation by Oxalobacter formigenes is important for human health, helping to prevent hyperoxaluria and disorders such as the development of kidney stones.
Some antibiotics affect colonization with Oxalobacter formigenes.
Oxalate degradation by the anaerobic bacterium Oxalobacter formigenes is important for human health, helping to prevent hyperoxaluria and disorders such as the development of kidney stones.
-O. formigenes may be beneficial to host thyroid function by lowering circulating oxalate.
References:
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- Our research team was not able to find negative outcomes of increased Oxalobacter formigenes levels in the gut at this point. Most of the existing studies and research papers are addressing the positive effects of Oxalobacter formigenes in the gut, namely their ability to be able to reduce the incidence of kidney stones. Further investigation and research is needed to be able to interpret levels above the normal reference ranges.
- An increased level of Oxalobacter formigenes may be due to high levels of probiotics intake that are commonly found in yogurt and kefir as well as probiotic formulations.
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Studies suggest that the gut microbiome may play a role in calcium stone formation, and may therefore present a novel treatment approach. A low level of Oxalobacter formigenes has been identified as a risk factor for calcium oxalate stone formation.
O. formigenes breaks down oxalates in the gut, and if O. formigenes levels are low, oxalate levels can accumulate in the kidneys and potentially form calcium oxalate stones. The presence of O. formigenes is associated with a 70% reduction in the risk of recurrent kidney stones .
-Diminished O. formigenes colonization in the gut of urinary stone forming subjects was associated with reduced bone mineral density.
-Males carry O. formigenes at significantly lower abundance than females. This correlates with the higher kidney stone incidence in males compared to females.
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Anthony
Unlimited Plan Member since 2021
I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
Karin
Advanced Plan Member since 2020
What fantastic service and great, easy-to-follow layouts! I love your website; it makes it so helpful to see patterns in my health data. It's truly a pleasure to use. I only wish the NHS was as organized and quick as Healthmatters.io. You've set a new standard for health tracking!
Paul
Healthmatters Pro Member since 2024
As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
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