Oxalobacter formigenes


A healthy result should fall into the range 0 - 1.5 CFU/g stool.

Oxalobacter formigenes is a bacterium that colonizes the colon of a substantial proportion of the normal population and metabolizes dietary and endogenous oxalate and hence reducing the incidence of kidney stones.

More about kidney stones:

Kidney stones are hard deposits made of minerals and salts that form inside your kidneys. Kidney stones are common, affecting 1 in 11 people in the United States. The most common form of the condition is the calcium oxalate stone. Current treatments include dietary modification, medications, and surgical treatment. Dietary modifications include increasing fluids, increasing dietary calcium, and decreasing oxalate in the diet (e.g. spinach, rhubarb, potatoes, nuts), and avoiding high dose Vitamin C. Medications may be used to reduce calcium in the urine or to reduce uric acid levels.

Oxalate degradation by Oxalobacter formigenes is important for human health, helping to prevent hyperoxaluria and disorders such as the development of kidney stones.

Some antibiotics affect colonization with Oxalobacter formigenes

Oxalate degradation by the anaerobic bacterium Oxalobacter formigenes is important for human health, helping to prevent hyperoxaluria and disorders such as the development of kidney stones.

-O. formigenes may be beneficial to host thyroid function by lowering circulating oxalate.


  1. http://www.urologystone.com/CH18WhatsNew/2001AUA.html
  2. https://www.ncbi.nlm.nih.gov/pubmed/24857648
  3. https://www.ncbi.nlm.nih.gov/pubmed/23536130
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071521/
  5. https://aem.asm.org/content/68/8/3841
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151321/
  7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571629/ 
  8. https://www.ncbi.nlm.nih.gov/pubmed/12147479/
  9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362665/
  10. https://link.springer.com/article/10.1007%2Fs00203-016-1272-y
  11. https://jasn.asnjournals.org/content/19/6/1197.long
  12. https://www.tandfonline.com/doi/abs/10.3109/00365528009181482?journalCode=igas20 
  13. https://www.kidney-international.org/article/S0085-2538(15)55863-8/pdf

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