Short-Chain Fatty Acids (SCFA), Total


A healthy result should fall into the range 23.3 - 200 micromol/g.

Short-Chain Fatty Acids (SCFA), Total result calculator

insert the value from you Short-Chain Fatty Acids (SCFA), Total test result.

What does it mean if your Short-Chain Fatty Acids (SCFA), Total result is too low?

  • Low levels of bacteria that produce n-butyrate and propionate have been linked to inflammatory diseases such as ulcerative colitis (n-butyrate) and childhood asthma (propionate).
  • Patients with advanced colorectal adenoma have reduced fecal n-butyrate and studies indicate that SCFA may play an important role in protection against colorectal cancer. These SCFA, especially n-butyrate, can act in secondary chemoprevention by slowing growth and triggering apoptosis of colon cancer cells, and in primary prevention by activating drug metabolizing enzymes, reducing the mutation burden of carcinogens.
  • Consistent with their role in glucose homeostasis, fecal SCFA are often low when metabolic disease is present. Type 2 diabetes and gout have been associated with reduced abundance of butyrate-producing bacteria.
  • Low SCFA levels are associated with gut motility problems. Transit times > 50 hours may lead to reduced fecal SCFA due to enhanced colonic uptake.
  • Antibiotics reduce SCFA production and may be the cause of diarrhea.
  • Fecal SCFA levels tend to be higher in obese/overweight adults than in those who are lean.

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