Optimal Result: 368 - 6266 U/g.

Beta-glucuronidase is an enzyme produced by certain unfriendly gut bacteria. A proper balance of beta-glucuronidase is essential for good health and disease prevention.

What is Glucuronidation?

Glucuronidation is an essential detoxification proocess that inactivates and detoxifies hormones, neurotransmitters, drugs, mold toxins, and cancer-causing toxins.

References:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982897/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813552/
https://www.ncbi.nlm.nih.gov/pubmed/12197785
https://europepmc.org/abstract/med/18772850
https://www.hindawi.com/journals/jnme/2015/760689/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858007/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858007/
https://www.ncbi.nlm.nih.gov/pubmed/25799848
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858007/
https://www.ncbi.nlm.nih.gov/pubmed/9148858  
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858007/
https://www.ncbi.nlm.nih.gov/pubmed/8019514
https://europepmc.org/abstract/med/18772850
https://www.sciencedirect.com/science/article/pii/030438359090083A
https://www.ncbi.nlm.nih.gov/pubmed/14595593

What does it mean if your Beta-glucuronidase result is too low?

Beta-glucuronidase is an enzyme that is used to digest carbohydrates and is a product of E. coli and anaerobic bacteria (bacteroides and clostridia). It is a key component of phase II detoxification (glucuronidation pathway) that helps clear pharmaceuticals, carcinogens, bile acids, and estrogen. Low levels would suggest a lack of E. coli and anaerobes or an overutilization of the glucuronidation pathway due to high toxic load. This can be difficult to interpret. But we generally want more beta-glucuronidase.

If low levels, replenish healthy bacteria and reduce toxic load.

What does it mean if your Beta-glucuronidase result is too high?

High levels of beta glucuronidase inhibits this glucuronidation process to detoxify the body from both natural hormones (ex: estrogens) and various environmental toxins.

High levels of beta-glucuronidase in the stool can be caused by a number of factors which are primarily due to the following diet and lifestyle habits:

– High fat diet
– Processed food consumption
– Sugar consumption
– Alcohol consumption
– Smoking

Taking antibiotics can also increase beta-glucuronidase as antibiotics destroy gut bacteria.

The following cancers have been identified with high beta-glucuronidase levels:

– Colon cancer
– Prostate cancer
– Breast cancer

How to lower Beta-glucuronidase levels?

In order to maintain good health and to lower the risk of the above referenced cancers, it is important to keep beta-glucuronidase activity low but sufficient enough to assist in the nutrient absorption process. Adhering to a low fat, whole food plant-based diet could be an important step to decrease Beta-glucuronidase

There are also some specific natural substances that may lower Beta-glucuronidase:

– Apple Pectin
– Calcium, iron, magnesium
– Calcium-D-Glucarate
– Milk thistle (Silymarin)
– Cumin / black pepper
– Fenugreek Seeds

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