Bacteroides uniformis is a fiber-degrading bacteria. It colonizes the gut in early infancy and is promoted by breast feeding.
Thought to enhance the gut barrier through the production of butyrate and GABA. Also produces beta glucuronidase, degrades mucin, and produces folate.
Studied in preclinical trials as a potential probiotic for use in inflammatory and metabolic disorders.
B. uniformis was found to be decreased in obese patients as compared to healthy or lean groups. It was higher in healthy controls as compared to patients with ulcerative colitis.
Enriched in healthy individuals versus colorectal cancer patients.
Associated with degradation of the isoflavone genistein, which then becomes less bioavailable to the human.
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Lin D, Peters BA, Friedlander C, et al. Association of dietary fibre intake and gut microbiota in adults. Br J Nutr. 2018;120(9):1014-1022.
Xing C, Du Y, Duan T, et al. Interaction between microbiota and immunity and its implication in colorectal cancer. Front Immunol. 2022;13:963819.
Takahashi K, Nishida A, Fujimoto T, et al. Reduced Abundance of Butyrate-Producing Bacteria Species in the Fecal Microbial Community in Crohn’s Disease. Digestion. 2016;93(1):59-65.
Pellock SJ, Walton WG, Biernat KA, et al. Three structurally and functionally distinct β-glucuronidases from the human gut microbe Bacteroides uniformis. J Biol Chem. 2018;293(48):18559-18573.
Qiao S, Bao L, Wang K, et al. Activation of a Specific Gut Bacteroides-Folate-Liver Axis Benefits for the Alleviation of Nonalco- holic Hepatic Steatosis. Cell Rep. 2020;32(6):108005.
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Duan M, Wang Y, Zhang Q, Zou R, Guo M, Zheng H. Characteristics of gut microbiota in people with obesity. PloS one. 2021;16(8):e0255446.
Dugas LR, Bernabe BP, Priyadarshini M, et al. Decreased microbial co-occurrence network stability and SCFA receptor level correlates with obesity in African-origin women. Sci Rep. 2018;8(1):17135.
Nomura K, Ishikawa D, Okahara K, et al. Bacteroidetes Species Are Correlated with Disease Activity in Ulcerative Colitis. J Clin Med. 2021;10(8).
Wang T, Cai G, Qiu Y, et al. Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers. ISME J. 2012;6(2):320-329.
Renouf M, Hendrich S. Bacteroides uniformis is a putative bacterial species associated with the degradation of the isoflavone genistein in human feces. J Nutr. 2011;141(6):1120-1126.
Queipo-Ortuno MI, Boto-Ordonez M, Murri M, et al. Influence of red wine polyphenols and ethanol on the gut microbiota ecology and biochemical biomarkers. Am J Clin Nutr. 2012;95(6):1323-1334.
Zengul AG, Demark-Wahnefried W, Barnes S, et al. Associations between Dietary Fiber, the Fecal Microbiota and Estrogen Metabolism in Postmenopausal Women with Breast Cancer. Nutr Cancer. 2021;73(7):1108-1117.
Li Y, Wang DD, Satija A, et al. Plant-Based Diet Index and Metabolic Risk in Men: Exploring the Role of the Gut Microbiome. J Nutr. 2021;151(9):2780-2789.
Ruengsomwong S, Korenori Y, Sakamoto N, Wannissorn B, Nakayama J, Nitisinprasert S. Senior Thai fecal microbiota comparison between vegetarians and non-vegetarians using PCR-DGGE and real-time PCR. J Microbiol Biotechnol. 2014;24(8):1026-1033.
Higher fiber intake from beans is associated with lower abundance of B. uniformis.
In ten healthy males, the consumption of red wine polyphenols for 4 weeks significantly increased the amount of Bacteroides uniformis as well as other commensal bacteria species.
Higher levels of insoluble fiber are associated with higher levels of B. uniformis.
A more favorable metabolic risk profile in men on a healthy plant-based diet was seen with a certain microbial profile featuring increased B. uniformis and decreased Prevotella copri.
The healthy diet was characterized by a higher intake of fiber, plant proteins, whole grains, fruits, vegetables, nuts, and legumes, and a lower intake of energy, animal proteins, refined grains, potatoes, sweets, animal fat, egg, dairy, and meats.
A small study (n=13) showed the presence of B. uniformis and other Bacteroides species in non-vegetarians, versus vegetarians.
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