8-OHdG (urine)

Optimal Result: 0 - 15 mcg/g Creat..

8-hydroxy- 2’-deoxyguanosine (8-OHdG) is a byproduct of oxidative damage to guanine bases in DNA. It is used as a biomarker for oxidative stress and carcinogenesis.

It has been studied to estimate DNA damage after exposure to carcinogens including tobacco smoke, asbestos fibers, heavy metals, and polycyclic aromatic hydrocarbons.

8-OHdG levels are positively associated with markers of inflammation and evening cortisol, indicating that increased physiological or psychosocial stress is associated with increased oxidative damage.


- Wu LL, Chiou CC, Chang PY, Wu JT. Urinary 8-OHdG: a marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics. Int J Clin Chem. 2004;339(1-2):1-9.

- Arab H, Mahjoub S, Hajian-Tilaki K, Moghadasi M. The effect of green tea consumption on oxidative stress markers and cognitive function in patients with Alzheimer’s disease: A prospective intervention study. Casp J Int Med. 2016;7(3):188-194.

- Graille M, Wild P, Sauvain JJ, Hemmendinger M, Guseva Canu I, Hopf NB. Urinary 8-OHdG as a Biomarker for Oxidative Stress: A Systematic Literature Review and Meta-Analysis. Int J Mol Sci. 2020;21(11).

- Valavanidis A, Vlachogianni T, Fiotakis C. 8-hydroxy-2’ -deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesis. J Environ Sci Health Part C, Environ CarcinEcotoxicol Rev. 2009;27(2):120-139.

- Black CN, Bot M, Revesz D, Scheffer PG, Penninx B. The association between three major physiological stress systems and oxidative DNA and lipid damage. Psychoneuroendocrinology. 2017;80:56- 66.

- Irie M, Tamae K, Iwamoto-Tanaka N, Kasai H. Occupational and lifestyle factors and urinary 8-hydroxydeoxyguanosine. Cancer Sci. 2005;96(9):600-606.

- Di Minno A, Turnu L, Porro B, et al. 8-Hydroxy-2-deoxyguanosine levels and heart failure: A systematic review and meta-analysis of the literature. Nutr Metab Cardiovasc Dis. 2017;27(3):201-208.

- Guo C, Li X, Wang R, et al. Association between Oxidative DNA Damage and Risk of Colorectal Cancer: Sensitive Determination of Urinary 8-Hydroxy-2’-deoxyguanosine by UPLC-MS/MS Analysis. Sci Rep. 2016;6:32581.

- Qing X, Shi D, Lv X, Wang B, Chen S, Shao Z. Prognostic significance of 8-hydroxy-2’-deoxyguanosine in solid tumors: a meta-analysis. BMC Cancer. 2019;19(1):997.

- Urbaniak SK, Boguszewska K, Szewczuk M, Kazmierczak-Baranska J, Karwowski BT. 8-Oxo-7,8-Dihydro-2’-Deoxyguanosine (8-oxodG) and 8-Hydroxy-2’-Deoxyguanosine (8-OHdG) as a Potential Biomarker for Gestational Diabetes Mellitus (GDM) Development. Molecules. 2020;25(1).

- Masugata H, Senda S, Murao K, et al. Association between urinary 8-hydroxydeoxyguanosine, an indicator of oxidative stress, and the cardio-ankle vascular index in hypertensive patients. J Atheroscl Thromb. 2012;19(8):747-755.

- Ece H, Mehmet E, Cigir BA, et al. Serum 8-OHdG and HIF-1α levels: do they affect the development of malignancy in patients with hypoactive thyroid nodules? Contemp Oncol. 2013;17(1):51-57.

- Halczuk KM, Boguszewska K, Urbaniak SK, Szewczuk M, Karwowski BT. 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodG) and 8-hydroxy-2’-deoxyguanosine (8-OHdG) as a Cause of Autoimmune Thyroid Diseases (AITD) During Pregnancy? Yale J Biol Med. 2020;93(4):501-515.

- Kawasaki Y, Li YS, Ootsuyama Y, Nagata K, Yamato H, Kawai K. Effects of smoking cessation on biological monitoring markers in urine. Genes Environ. 2020;42:26.

- Hara M, Nishida Y, Shimanoe C, et al. Intensity-specific effect of physical activity on urinary levels of 8-hydroxydeoxyguanosine in middle-aged Japanese. Cancer Sci. 2016;107(11):1653-1659.

What does it mean if your 8-OHdG (urine) result is too high?

Elevated 8-OHdG indicates oxidative damage to DNA.

Diseases including cardiovascular disease, COPD, cancer, thyroid disease, and diabetes have been associated with excessive concentrations of 8-OHdG.

Minimizing exposure to xenobiotics and cigarette smoke, stress management, and increasing antioxidant intake may prevent further oxidative damage.

Increased physical activity is associated with a reduction in urinary 8-OHdG levels.

Green tea catechins decreased 8-OHdG concentrations in patients with Alzheimer’s disease.

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