a-Amino-N-butyric Acid

Optimal Result: 2 - 21 micromol/g creatinine.

3200 Metabolomix+ - FMV Urine Genova Diagnostics

From Healthmatters.io Team

Lab Results Explained and Tracked

Alpha-Amino-N-butyric acid (α-ANB), also known as alphaaminobutyric acid, is a nonessential amino acid derived from the catabolism of methionine, threonine, and serine. α-ANB is both formed and metabolized by reactions which require vitamin B6 as a cofactor.

References:

- Shaw S, Lieber CS. Plasma amino acids in the alcoholic: nutritional aspects. Alc Clin Exp Reds. 1983;7(1):22-27.

- Kang-Yoon SA, Kirksey A. Relation of short-term pyridoxineHCl supplementation to plasma vitamin B-6 vitamers and amino acid concentrations in young women. Am J Clin Nutr. 1992;55(4):865-872.

- Steele RD. Transaminative metabolism of alpha-amino-n-butyrate in rats. Metab: Clin Exp. 1982;31(4):318-325.

- Shaw S, Stimmel B, Lieber CS. Plasma alpha amino-n-butyric acid to leucine ratio: an empirical biochemical marker of alcoholism. Science. 1976;194(4269):1057-1058.

- Shaw S, Lieber CS. Increased hepatic production of alphaamino-n-butyric acid after chronic alcohol consumption in rats and baboons. Gastroenterology. 1980;78(1):108-113.

- Lieber CS. Role of oxidative stress and antioxidant therapy in alcoholic and nonalcoholic liver diseases. Adv Pharmacol. 1997;38:601-628.

- Chiarla C, Giovannini I, Siegel JH. Characterization of alphaamino-n-butyric acid correlations in sepsis. Transl Res. 2011;158(6):328-333.

- Moszak M, Klupczynska A, Kanikowska A, et al. The influence of a 3-week body mass reduction program on the metabolic parameters and free amino acid profiles in adult Polish people with obesity. Adv Clin Exp Med. 2018;27(6):749-757.

- Adachi Y, Toyoshima K, Nishimoto R, et al. Association between plasma alpha-aminobutyric acid and depressive symptoms in older community-dwelling adults in Japan. Geriatr Gerontol Int. 2019;19(3):254-258.

- Le Couteur DG, Ribeiro R, Senior A, et al. Branched chain amino acids, cardiometabolic risk factors and outcomes in older men: the Concord Health and Ageing in Men Project. J Gerontol Series A, Biol Sci Med Sci. 2019.

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What does it mean if your a-Amino-N-butyric Acid result is too high?

Levels of this metabolite may be elevated if its precursors are also elevated. A functional need for vitamin B6 can limit the further metabolism of α-ANB and contribute to elevated levels. Elevations of this metabolite have been studied in several conditions which contribute to a functional vitamin B deficiency, such as alcoholism, sepsis, hypocaloric weight loss, and excessive exercise.

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What does it mean if your a-Amino-N-butyric Acid result is too low?

Low levels of α-ANB may be seen when overall amino acids are low, especially it’s precursors. Additionally, a functional deficiency in vitamin B6 has been associated with lower levels of α-ANB and levels can increase with B6 supplementation. Clinically, low levels of plasma α-ANB have been associated with depressive symptoms.

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a-Amino-N-butyric Acid

All Your Lab Results. One Simple Dashboard.

What does it mean if your a-Amino-N-butyric Acid result is too high?

All Your Lab Results. One Simple Dashboard.

Import, Track, and Share Your Lab Results Easily

Import, Track, and Share Your Lab Results

What does it mean if your a-Amino-N-butyric Acid result is too low?

Article Review & Sources

Bring All Your Lab Results Together — In One Place

Gather Your Lab History — and Finally Make Sense of It

Finally, Your Lab Results Organized and Clear

Advanced Plan

Unlimited Account

Pro Monthly

What's included in a Healthmatters membership

Import Lab Results from Any Source

See Your Health Timeline

Understand What Your Results Mean

Enter Your Lab Reports Yourself — Always Free Enter Your Lab Reports — Always Free

Visualize Your Results

Export Your Complete Lab History in a Single File Export Your Complete Lab History

Comprehensive Data Entry Service for Your Reports Data Entry Service for Your Reports

Securely Share With Anyone You Trust

Let Your Lab Results Tell the Full Story

Once your results are in one place, see the bigger picture — track trends over time, compare data side by side, export your full history, and share securely with anyone you trust.

Bring all your results together to compare, track progress, export your history, and share securely.

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All Your Lab Results.
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