Used in integrated circuits, LED’s, solar cells, laser diodes. It is also used in medicine, where the radioisotopes are used as imaging agents,and stable compounds are used in chemotherapy. Ga can be a antimicrobial agent, and used to treat life-threatening, malignancyrelated hypercalcemia. Can be found in ground water near mining, manufacturingand coal combustion plants. Most commonly seen in occupationalexposures, while thereis less data on consumer electronic exposures.
Ga competes with iron for transferrin binding and inhibits receptor-mediated iron uptake by cells, renderingcells irondeficient. Iron replacement has been shown to restore hemoglobin production in Ga exposed cells. It was also found to interact with bone metabolism and to lower calcium levels in the blood.
Ga binds to transferrin and interferes with protein synthesis and the heme pathway. It’s use in medicine shows that it tends to localize to tumorsand cause cell death via interference with iron metabolism. Ga is excreted in the urine,and in rats, renal toxicity was noted with the formation ofprecipitatesofgallium complexed with calcium and phosphate.
Chitambar CR. Gallium Complexes as Anticancer Drugs. Metallo-Drugs: Development and Action of Anticancer Agents. 2018;18:281.
White SJO, Shine JP. Exposure potential and health impacts of indium and gallium, metals critical to emerging electronics and energy technologies. Curr Environ Health Rep. 2016;3(4):459-467.
Chitambar CR. Gallium and its competing roles with iron in biological systems. Biochim Biophysi Acta Mol Cell Res. 2016;1863(8):2044-2053.
Hayes AW. Principles and methods of toxicology. Crc Press; 2007.
In animal studies, toxicity is associated with pulmonary conditions, immunosuppressive effects, and renal toxicity. Direct exposureto Ga has been shown to cause skin rashes, and neurological pain and weakness. Anemia is possible due to its interference with heme pathways.
Own it for life
Our exclusive data entry service is a convenient way to get your results into your private dashboard. Simply attach an image or a file of your lab test results, and one of our qualified data entry team members will add the results for you. We support all sorts of files, whether PDFs, JPGs, or Excel. This service is excellent whether you have a lot of reports to upload or are too busy to do the data entry yourself.
We strive to make the data entry process easy for you. Whether by offering dozens of templates to choose from that pre-populate the most popular laboratory panels or by giving you instant feedback on the entered values. Our data entry forms are an easy, fast, and convenient way to enter the reports yourself. There is no limit on how many lab reports you can upload.
billed every month
Data entry included
$6.60/month billed annually
Data entry included
own it for life
Are You a Health Professional?
Get started with our professional plan
Welcome to Healthmatters Pro.
Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place. Learn more
Pro Monthly Plus
for health professionals
$75 per month