Eicosadienoic acid (EDA) is a rare, omega-6 fatty acid with a 20-carbon backbone and two double bonds (20:2n6). It is mainly formed through the downstream metabolism of omega-6s by elongating LA. EDA can be metabolized to form DGLA and AA. Literature is sparse regarding its role in the inflammatory cascade though it is known to modulate the metabolism of other PUFAs and to alter the responsiveness of macrophages to stimulate inflammation.
- Huang YS, Huang WC, Li CW, Chuang LT. Eicosadienoic acid differentially modulates production of pro-inflammatory modulators in murine macrophages. Molecular and cellular biochemistry. 2011;358(1-2):85-94.
Lower levels may be due to decreased dietary intake of omega-6 foods or decreased downstream metabolism of LA and other omega-6s. There is no known clinical significance of decreased levels.
Elevations may be seen with high intake of LA and omega-6 fatty acid-rich foods. The clinical significance of elevations is presumed due to its role in the inflammatory cascade, though in and of itself, EDA hasn’t yet been studied epidemiologically for disease associations.
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